Chemical composition and biological activity of the essential oil from <i>Thymus lanceolatus</i>

Khadir, Abdelmounaïm; Sobeh, Mansour; Gad, Haidy A.; Benbelaïd, Fethi; Bendahou, Mourad; Peixoto, Herbenya; Sporer, Frank; Ashour, Mohamed L.

doi:10.1515/znc-2016-0005

Cited by 27 publications

(19 citation statements)

References 37 publications

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“…An MTT colorimetric test previously described by Mosmann [72] is one of the most commonly used methods for in vitro evaluation of cytotoxicity using a microtitre plate design. This method is applicable to the toxicological assessment of natural products [73], including volatiles [74]. Volatile substances can influence the results of biological assays using a microtitre plate as has been de- scribed by several authors [75,76].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Volatile Antimicrobial Agents and In Vitro Methods for Evaluating Their Activity in the Vapour Phase: A Review

Houdková

Kokoška

2020

Planta Med

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This review summarizes data on the in vitro antimicrobial effectiveness of volatile agents of plant origin and in vitro methods for evaluating their activity in the vapour phase. As a result of literature analysis, the antimicrobial efficacy of vapours from 122 different plant species and 19 pure compounds examined in 61 studies using different in vitro tests against a broad spectrum of microorganisms was identified and summarized. In addition, 11 different techniques found in the literature are described in detail. An original classification of methods based on the solid and liquid matrix volatilization principle is proposed because carrier medium/matrix selection is crucial for the volatilization of any agents tested. This review should be useful for medicinal, pharmaceutical, food, and agricultural experts working in areas related to the management of infectious diseases (especially respiratory and skin infections), food preservation (active packaging), and protection of agriculture products (controlled atmosphere). It may also stimulate the interest of pharmaceutical, cosmetic, food, and agriculture industries in the research and development of new antimicrobial agents of natural origin. Since several original apparatuses previously developed for antimicrobial susceptibility testing in the vapour phase are described in this review, labware manufacturers may also be interested in this topic. The review also provides specific guidelines and recommendations for researchers studying the antimicrobial activity of volatile agents. The article will therefore appeal to communities of industrial stakeholders, pharmacists, physicians, food experts, agriculturists, and researchers in related areas such as pharmacology, medicinal chemistry, microbiology, natural product chemistry, food preservation and plant protection.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Volatile Antimicrobial Agents and In Vitro Methods for Evaluating Their Activity in the Vapour Phase: A Review

Houdková

Kokoška

2020

Planta Med

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“…Some authors believe that the linalool has antifungal, antimicrobial [25, 26], antitumor [27], antimutagenic [28], analgesic, antispasmodic [29], anti-inflammatory [30], antiparasitic [31], antiplatelet, and antioxidant activity [32]. The chemical structure of major compounds identified in the essential oil of the species is shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition andIn VitroAntioxidant, Cytotoxic, Antimicrobial, and Larvicidal Activities of the Essential Oil ofMentha piperitaL. (Lamiaceae)

Ramos

Rodrigues

Farias

et al. 2017

The Scientific World Journal

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The essential oil was obtained by hydrodistillation and the identification and quantification of components were achieved with the use of GC-MS analysis. The antioxidant activity was evaluated by the method of sequestration of DPPH. Essential oils were used for study the cytotoxic front larvae of Artemia salina. In the evaluation of the antimicrobial activity of essential oils, we employed the disk-diffusion method. The potential larvicide in mosquito larvae of the third stage of development of Aedes aegypti to different concentrations of essential oils was evaluated. The major compounds found in the essential oils of M. piperita were linalool (51.8%) and epoxyocimene (19.3%). The percentage of antioxidant activity was 79.9 ± 1.6%. The essential oil showed LC50 = 414.6 μg/mL front of A. saline and is considered highly toxic. It shows sensitivity and halos significant inhibition against E. coli. The essential possessed partial larvicidal efficiency against A. aegypti.

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“…Thymol triggered cytotoxicity in MCF-7 breast cancer cell lines with an LC 50 of 2.5 μg/mL ( Melo et al, 2014 ). In another study, Thymol present in the essential oil of T. lanceolatus (IC 50 = 304.81 μg/ml) was shown to induce cytotoxicity and proliferation in MCF-7 cells ( Khadir et al, 2016 ).…”

Section: Thymol In Cancer Cellsmentioning

confidence: 99%

Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development

et al. 2017

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Thymol, chemically known as 2-isopropyl-5-methylphenol is a colorless crystalline monoterpene phenol. It is one of the most important dietary constituents in thyme species. For centuries, it has been used in traditional medicine and has been shown to possess various pharmacological properties including antioxidant, free radical scavenging, anti-inflammatory, analgesic, antispasmodic, antibacterial, antifungal, antiseptic and antitumor activities. The present article presents a detailed review of the scientific literature which reveals the pharmacological properties of thymol and its multiple therapeutic actions against various cardiovascular, neurological, rheumatological, gastrointestinal, metabolic and malignant diseases at both biochemical and molecular levels. The noteworthy effects of thymol are largely attributed to its anti-inflammatory (via inhibiting recruitment of cytokines and chemokines), antioxidant (via scavenging of free radicals, enhancing the endogenous enzymatic and non-enzymatic antioxidants and chelation of metal ions), antihyperlipidemic (via increasing the levels of high density lipoprotein cholesterol and decreasing the levels of low density lipoprotein cholesterol and low density lipoprotein cholesterol in the circulation and membrane stabilization) (via maintaining ionic homeostasis) effects. This review presents an overview of the current in vitro and in vivo data supporting thymol’s therapeutic activity and the challenges concerning its use for prevention and its therapeutic value as a dietary supplement or as a pharmacological agent or as an adjuvant along with current therapeutic agents for the treatment of various diseases. It is one of the potential candidates of natural origin that has shown promising therapeutic potential, pharmacological properties and molecular mechanisms as well as pharmacokinetic properties for the pharmaceutical development of thymol.

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Chemical composition and biological activity of the essential oil from Thymus lanceolatus

Cited by 27 publications

References 37 publications

Volatile Antimicrobial Agents and In Vitro Methods for Evaluating Their Activity in the Vapour Phase: A Review

Volatile Antimicrobial Agents and In Vitro Methods for Evaluating Their Activity in the Vapour Phase: A Review

Chemical Composition andIn VitroAntioxidant, Cytotoxic, Antimicrobial, and Larvicidal Activities of the Essential Oil ofMentha piperitaL. (Lamiaceae)

Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development

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