Chemical composition and biological activity of triterpenes and steroids of chaga mushroom

Nikitina, S.A.; Habibrakhmanova, V. R.; Сысоева, М А

doi:10.1134/s1990750816010108

Cited by 8 publications

(8 citation statements)

References 33 publications

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“…Currently, approximately 40 triterpene compounds of the lanostane series have been isolated from I. obliquus , as well as trace amounts of pentacyclic triterpenes such as betulin, lupeol, and lupenon (Gao, Xu, Lu, & Xu, ). Furthermore, steroids, mainly ergosterol and other typically plant‐derived steroidal compounds such as sitosterol, and stigmasterol have been identified, whereas the ergosterol content of I. obliquus was found to be lower when compared with the triterpene content (Nikitina, Khabibrakhmanova, & Sysoeva, ). The β‐ D ‐glucose polysaccharide (β‐glucan) content of I. obliquus is also a predominant bioactive compound that has attracted much interest owing to its beneficial properties on health as a prebiotic, and hypoglycemic agent (Ham et al, ).…”

Section: Chemical Analysis Of I Obliquusmentioning

confidence: 99%

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

Duru

Kovaleva

Данилова

et al. 2019

Phytotherapy Research

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The use of mushrooms as functional foods and in the treatment of diseases has a long history. Inonotus obliquus is a mushroom belonging to the Hymenochaetaceae family and has possible anticancer, antiviral, and hypoglycemic properties. Chemical analysis of this mushroom has allowed the identification of various constituents such as melanins, phenolic compounds, and lanostane-type triterpenoids. A plethora of findings have highlighted the potential molecular mechanisms of actions of this mushroom such as its ability to scavenge reactive oxygen species, inhibit the growth of tumors, decrease inflammation and insulin resistance in type 2 diabetes, and stimulate the immune system. This review summarizes the relevant findings with reference to the therapeutic potential of this mushroom in countering the progression of cancers, diabetes mellitus, and antiviral activities, while highlighting its possible molecular mechanisms of action. The possible role of this mushroom as a therapeutic agent in addressing the pathogenesis of diabetes and cancer has also been suggested.

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Section: Chemical Analysis Of I Obliquusmentioning

confidence: 99%

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

Duru

Kovaleva

Данилова

et al. 2019

Phytotherapy Research

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“…The isolation and identification methods of these compounds are also briefly given in Table 2. Moreover, the review of Nikitina et al (2016), which summarized the original Russian articles, may provide different structural information about chaga terpenoids from those given in this contribution that is built upon using the English source. Lanostane-type terpenoids are well known for their potential in cancer treatment (Duru and Çayan, 2015).…”

Section: Terpenoidsmentioning

confidence: 99%

Bioactive Compounds and Bioactive Properties of Chaga (Inonotus obliquus) Mushroom: A Review

Peng¹,

Shahidi²

2020

JFB

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Chaga (Inonotus obliquus) is an edible herbal mushroom extensively distributed in the temperate to frigid regions of the Northern hemisphere, especially the Baltic and Siberian areas. Chaga parasites itself on the trunk of various angiosperms, especially birch tree, for decades and grows to be a shapeless black mass. The medicinal/nutraceutical use of chaga mushroom has been recorded in different ancient cultures of Ainu, Khanty, First Nations, and other Indigenous populations. To date, due to its prevalent use as folk medicine/functional food, a plethora of studies on bioactive compounds and corresponding compositional analysis has been conducted in the past 20 years. In this contribution, various nutraceutical and pharmaceutical potential, including antioxidant, anti-inflammatory, anti-tumor, immunomodulatory, antimutagenic activity, anti-virus, analgesic, antibacterial, antifungal, anti-hyperglycemic, and anti-hyperuricemia activities/effects, as well as main bioactive compounds including phenolics, terpenoids, polysaccharides, fatty acids, and alkaloids of chaga mushroom have been thoroughly reviewed, and tabulated using a total 171 original articles. However, only key bioactivities and bioactives are selectively discussed. Besides, the up-to-date toxicity concerns and risk assessment about the misuse of chaga, which limit its acceptance and use as medicinal/nutraceutical products, have also been clarified.

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“…It is worth noting that I. obliquus can be found not only in natural environment, but it also be cultivated on different substrates using malt, birch saw dust, grain and potato dextrose agar [13], however, the composition of its metabolites and similarity to native chaga is not much studied.…”

Section: Introductionmentioning

confidence: 99%

Extraction possibilities of lipid fraction and authentication assessment of chaga (Inonotus obliquus)

Upska

Kļaviņš

Radenkovs

et al. 2022

Biomass Conv. Bioref.

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Chaga (Inonotus obliquus) (Fr.) Pilát is a black perennial fungus that grows on adult birch trunk and traditionally been used as a health prevention remedy in different countries. The lipophilic compounds of chaga were isolated applying conventional (Soxhlet), non-conventional (ultra-sound assisted, accelerated solvent) and environmentally friendly (supercritical fluid) extraction methods utilizing both polar and non-polar solvents. For authentication of chaga samples, isotope ratio mass spectrometry (IRMS) and multi-elemental analysis was performed in this study. The yield and profile of lipids, sterols, and triterpenoids of various origins were discussed and potential application in terms of antimicrobial activity against pathogenic and opportunistic pathogenic microorganisms demonstrated. The results showed that CO2 extraction delivered comparable to conventional extraction techniques amount of target compounds with a safer profile and therefore could represent the future for sustainable industrial-scale production of biologically active ingredients with antimicrobial activity. Authentication of chaga allowed to establish the quality parameters and properties of resources that will be useful for industries.

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Chemical composition and biological activity of triterpenes and steroids of chaga mushroom

Cited by 8 publications

References 33 publications

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

Bioactive Compounds and Bioactive Properties of Chaga (Inonotus obliquus) Mushroom: A Review

Extraction possibilities of lipid fraction and authentication assessment of chaga (Inonotus obliquus)

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