Chemical Composition and Biological Activities of <i>Allium roseum</i> L. var. grandiflorum Briq. Essential Oil

Abstract

International audienceAllium roseum L. (Alliaceae) endemic mediterranean specie was represented in the North Africa by 12 different taxa. In the present study, chemical composition, antiproliferative, antioxidant and antimicrobial activities of the essential oil extracted from A. roseum var. grandiflorum Briq. bulbs collected in the North of Tunisia were investigated. Chemical characterization has shown methyl methanethiosulfinate as major sulphurous compounds. A. roseum bulbs essential oil provides interesting antiproliferative activity against two human colonic adenocarcinoma HT29 and CACO2 cell lines in dose-dependent manner with a half-maximal inhibition (IC50) of 4.64 µg/mL and 8.22 µg/mL respectively. The antioxidant activity, as determined by FRAP assay, was 285 µmol equivalent Trolox/g of essential oil. The scavenging effect on DPPH radicals of essential oil was estimated as IC50 values at 156 µg/mL. The inhibition of superoxide anion production in a model of cancer cell lines was significant for both lines HT29 and CACO2 with IC50 of 20.25 µg/mL and 29.12 µg/mL respectively. Allium roseum essential oil exhibited antibacterial and antifungal activities with a high effectiveness against Candida albicans given by an MIC value of 0.019 mg/mL. This biological effect appears to be related mainly to the presence of organosulfur compounds

Effects of ethylthiosulfanylate and chromium (VI) on the state of pro/antioxidant system in rat liver

“…Sulfur-containing compounds have the ability to inhibit the activity of the xanthine-xanthine oxidase system and attenuate ROS-induced lipids and proteins peroxidation [22]. Garlic organosulfur compounds also attenuate lipids peroxidation by inhibition of xanthine-xanthine oxidase-induced ROS generation [23]. In addition, during biotransformation processes, thiosulfonates are able to transform into other sulfur-containing compounds and thiols, which can be further used as a material for the synthesis of GSH molecules [24].…”

Antimicrobial, Antioxidant, and Immunomodulatory Properties of Essential Oils: A Systematic Review

“…EOs from Heracleum pyrenaicum subsp. orsinii , Pistacia vera L., Myrcia ovata Cambessedes , Thymus bovei , Minthostachys verticillata , Allium roseum , Petroselinum crispum , Satureja bachtiarica Bunge, Ocimum suave , Jatropha gossypifolia L., and Juniperus rigida have been shown to exert antibacterial and anti-yeast effects [34,37,41,43,47,48,51,64,67,68,69]. One of the proposed mechanisms for those effects is the irreversible damage of the bacteria cell wall and membrane, which leads to not only a leakage of proteins but also of DNA and RNA molecules [47,48].…”

“…Likewise, in human colonic adenocarcinoma cancer cell lines (HT29-D4 and Caco-2 cell), Allium roseum L. EO has a growth-inhibitory effect in a dose-dependent manner, without being cytotoxic. This effect has been attributed to the presence of sulfurous compounds as the major constituents of this EO [68]. Conversely, Cirsium japonicum DC EOs could promote cell proliferation in the human pulmonary adenocarcinoma A549 cell line [92].…”

Chemical composition and biological activities essential oil from the needles African of Pinus pinaster Var.

“…Pinus pinaster needles exhibited a low yield of the essential oils when compared with Aleppo pine needles growing in Algeria with a yield of 0.52%. 14 The chemical composition of the essential oil of needles was investigated using GC-FID and GC-MS apparatus. The chromatograms of P. pinaster of two varieties showed that the essential oils were a mixture of numerous compounds; some of them were present in trace amounts.…”