Chemical Composition and Biological Activities of Essential Oils from Two Wild Algerian Medicinal Plants: <i>Mentha pulegium</i> L. and <i>Lavandula stoechas</i> L.

Baali, Faiza; Boumerfeg, Sabah; Napoli, Edoardo; Boudjelal, Amel; Righi, Nadjat; Deghima, Amirouche; Baghiani, Abderrahmane; Ruberto, Giuseppe

doi:10.1080/0972060x.2019.1642800

Cited by 32 publications

(18 citation statements)

References 33 publications

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“…Of these 10 constituents, one was cyclohexanone,2-methyl-5-(1methylethenyl) which is commonly known as camphor. The results of phytochemical analysis correlated well with previously reported studies such as gas chromatographic analysis of Lavandula stoechas L. extract revealed the presence linalyl acetate, γ-terpinene and camphor [35]. According to literature, antipruritic and antimicrobial activity of camphor has been well documented.…”

Section: Discussionsupporting

confidence: 89%

“…In the present investigation, oral administration of ethanol successfully induced the peptic ulcer in experimental rats [35]. However, oral treatment of rats with Lavandula stoechas L. prior to induction of disease protected the animals against both ethanolinduced gastric (P < 0.001) and duodenal (P < 0.01) ulcers as compared to disease control (Fig.…”

Section: Discussionmentioning

confidence: 46%

“…omeprazole and ranitidine also protected the animals against peptic ulcer. The exact mechanism how ethanol causes gastric lesions is not fully understood [9, 10] however, ethanol is reported to produce a disturbance in gastric mucosal barrier via exfoliation of cells [11,35] followed by the recruitment of inflammatory cells to the site of injury and production of reactive oxygen species (ROS). As ROS and other mediators of inflammation may lead to oxidative damage [12,36] therefore, by scavenging free radicals, antioxidants might prove as useful gastroprotective agents.…”

Section: Discussionmentioning

confidence: 99%

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Pharmacological Evaluation of Lavandula stoechas L. for Ethanol-induced Gastric Mucosal Ulcer

Javed

Khan

Arshad³

et al. 2020

RADS J. Pharm. Pharm. Sci.

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Background: The constituents of Lavandula stoechas L. possess antioxidant properties that help in protecting the mucosal cells from oxidative damage and speed up the healing process however, its role in the treatment of ethanol-induced peptic ulcers is not clear. Objectives: We aimed to evaluate the pharmacological potential of Lavandula stoechas L. extracts for anti-ulcer activity, and compare with the standard drugs and to explore novel treatment for peptic ulcer. Methods: We evaluated anti-ulcer potential of plant extract in ethanol-induced ulcer model in rats. Omeprazole and ranitidine were standard drugs. After 5 h of disease induction, animals were sacrificed to get tissues for histological evaluation and ulcer index was measured. While the antimicrobial potential of Lavandula stoechas L. aqueous and methanolic extracts was evaluated against different bacterial stains using standard antibiotic discs. Qualitative phytochemical and GCMS analysis were performed to identify novel constituents. Results: The methanolic extract of Lavandula stoechas L. showed antimicrobial activity against Proteus Mirabilis while the GCMS based analysis revealed the presence of 10 phytochemicals including camphor (antimicrobial agent). The aqueous extract showed significant anti-ulcer activity in ethanol-induced gastric (P < 0.001) and duodenal (P < 0.01) ulcers when compared with controls. Aqueous and methanolic Lavandula stoechas L. extracts showed strong free radical scavenging activity. Conclusion: Lavandula stoechas L. extract possess antimicrobial and anti-ulcer activity in alcohol-induced ulcer model in experimental animals.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%

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Pharmacological Evaluation of Lavandula stoechas L. for Ethanol-induced Gastric Mucosal Ulcer

Javed

Khan

Arshad³

et al. 2020

RADS J. Pharm. Pharm. Sci.

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“…are likely to be due to its high concentration of CAM (about 27% of the oil) and EUCA (about 11% of the oil) ( Si et al., 2006 ). Furthermore, in recent studies ( Fidan et al., 2019 ; Zerkani et al., 2019 ; Baali et al., 2019 ), essential oils having BOR among their main constituents also showed antimicrobial activity.…”

Section: Introductionmentioning

confidence: 94%

Evaluation of dietary addition of 2 essential oils from Achillea moschata, or their components (bornyl acetate, camphor, and eucalyptol) on in vitro ruminal fermentation and microbial community composition

et al. 2021

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This study investigated the effects of 2 Achillea moschata essential oils extracted from plants collected in 2 different valleys of the Italian Alps and 3 pure compounds of oils — bornyl acetate (BOR), camphor (CAM), and eucalyptol (EUCA) — on in vitro ruminal fermentation and microbiota. An in vitro batch fermentation experiment (Exp. 1) tested the addition of all of the substances (2 essential oils and 3 compounds) in fermentation bottles (120 mL) at 48 h of incubation, whereas a subsequent in vitro continuous culture experiment (Exp. 2) evaluated the pure compounds added to the fermenters (2 L) for a longer incubation period (9 d). In both experiments, total mixed rations were incubated with the additives, and samples without additives were included as the control (CTR). Each treatment was tested in duplicate and was repeated in 3 and 2 fermentation runs in Exp. 1 and 2, respectively. Gas production (GP) in Exp. 1 was similar for all of the treatments, and short chain volatile fatty acid (SCFA) production was similar in both experiments except for a decrease of SCFA produced ( P = 0.029) due to EUCA addition in Exp. 2. Compared to CTR, BOR and CAM reduced the valerate proportion ( P = 0.04) in Exp. 1, and increased ( P < 0.01) the acetate proportion in Exp. 2. All treatments increased ( P < 0.01) total protozoa counts (+36.7% and +48.4% compared to CTR on average for Exp. 1 and 2, respectively). In Exp. 1, all of the treatments lowered the Bacteroidetes and Firmicutes and increased the Proteobacteria relative abundances ( P < 0.05), whereas in Exp. 2, the EUCA addition increased ( P = 0.012) the Ruminococcus . In Exp. 1, methane (CH 4 ) as a proportion of the GP was lowered ( P = 0.004) by the addition of CAM and EUCA compared to CTR, whereas in Exp. 2, EUCA reduced the amount of stoichiometrically calculated CH 4 compared to CTR. Overall, essential oils extracted from A. moschata and the pure compounds did not depress in vitro rumen fermentation, except for EUCA in Exp. 2. In both experiments, an increase of the protozoal population occurred for all the additives.

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“…As an example, essential oils bearing high amounts of phenolic derivatives such as carvacrol and thymol were demonstrated to exhibit strong antimicrobial effect against bacteria [1]. In addition, the abundant oxygenated monoterpenes in essential oils were reported to show higher antibacterial effect compared to those with monoterpene hydrocarbons [20]. The essential oil of P. trimera consisted of two main classes: oxygenated sesquiterpenes (41.7%) and sesquiterpene hydrocarbons (39.6%) with major constituents, namely β-caryophyllene (10.5%), β-caryophyllene oxide (9.9%), 7-epi-α-eudesmol (7.6%), and γ-muurolene (6.8%) [12].…”

Section: Discussionmentioning

confidence: 99%

Biological Activities of Essential Oils from Leaves of Paramignya trimera (Oliv.) Guillaum and Limnocitrus littoralis (Miq.) Swingle

Doan

et al. 2020

Antibiotics

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The present study aimed to determine the bioactivities of essential oils extracted from the leaves of Paramignya trimera and Limnocitrus littoralis, including cytotoxicity, antiviral, antibacterial, antimycotic, and antitrichomonas effects. Herein, it was indicated that P. trimera and L. littoralis oils showed no cytotoxicity on normal cells, namely MT-4, BHK-21, MDBK, and Vero-76. P. trimera oil (i) exhibited the strongest inhibition against Staphylococcus aureus with MIC and MLC values of 2% (v/v); (ii) showed MIC and MLC values of 8% (v/v) in Candida parapsilosis; and (iii) in the remaining strains, showed MIC and MLC values greater than or equal to 16% (v/v). On the other hand, L. littoralis oil (i) displayed the strongest inhibition against Candida tropicalis and Candida parapsilosis with 2% (v/v) of MIC and MLC; and (ii) in the remaining strains, possessed MIC and MLC greater than or equal to 16% (v/v). In addition, antitrichomonas activities of the oils were undertaken, showing IC50, IC90, MLC values, respectively, at 0.016%, 0.03%, and 0.06% (v/v) from P. trimera, and 0.03%, 0.06%, 0.12% (v/v) from L. littoralis, after 48 h of incubation. The oils were completely ineffective against ssRNA+ (HIV-1, YFV, BVDV, Sb-1, CV-B4), ssRNA- (RSV, VSV), dsRNA (Reo-1), and dsDNA (HSV-1, VV) viruses. This is the first report describing the cytotoxicity, antiviral, antibacterial, antimycotic, and antitrichomonas activities of the essential oils of P. trimera and L. littoralis.

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Chemical Composition and Biological Activities of Essential Oils from Two Wild Algerian Medicinal Plants: Mentha pulegium L. and Lavandula stoechas L.

Cited by 32 publications

References 33 publications

Pharmacological Evaluation of Lavandula stoechas L. for Ethanol-induced Gastric Mucosal Ulcer

Pharmacological Evaluation of Lavandula stoechas L. for Ethanol-induced Gastric Mucosal Ulcer

Evaluation of dietary addition of 2 essential oils from Achillea moschata, or their components (bornyl acetate, camphor, and eucalyptol) on in vitro ruminal fermentation and microbial community composition

Biological Activities of Essential Oils from Leaves of Paramignya trimera (Oliv.) Guillaum and Limnocitrus littoralis (Miq.) Swingle

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