Chemical composition and biological activities of the essential oils from Lippia alba and Lippia origanoides

Abstract

There is an increasing interest in essential oils extracted from Verbenaceae plant species as potential sources of biologically active compounds that could provide a starting point for designing novel phyto-pharmaceuticals in aquaculture. The present study was aimed to investigate the chemical composition, antioxidant activity, acute toxicity and antimicrobial effects against Vibrio parahaemolyticus of essential oils extracted from Lippia alba and L. origanoides. Approximately 23 components were identified and quantified by gas chromatography-mass spectrometry and flame ionization detection in each species' essential oil. The most predominant compounds were geranial (23.0%), limonene (17.0%) and neral (15.5%) in L. alba, and thymol (47.2%), p-cymene (16.0%) and E-caryophyllene (11.3%) in L. origanoides. The essential oils have antibacterial activity against Vibrio parahaemolyticus presenting Minimum Inhibitory Concentration (MIC) and Bactericidal Concentration (MBC) values between 156-625 µg mL -1 . The essential oils also show antioxidant potential estimated by 1,1-diphenyl-2picrylhydrazyl (DPPH) free radical scavenging assays, presenting IC 50 of 60.16 mg mL -1 and 0.22 mg mL -1 for L. alba and L. origanoides EO, respectively. Both oils were classified as toxic to Artemia salina nauplii. Therefore, these essential oils may be useful for controlling pathogenic bacteria important to the aquaculture industry.

Quimiotipos de Lippia origanoides Kunth na Amazonia e sua importância farmacológica: uma revisão

“…Atualmente, trabalhos têm demonstrado que as atividades biológicas e potencial antioxidante do EOLO estão relacionados aos quimiotipos e aos efeitos sinérgicos entre os fitoquímicos bioativos, presentes no EOLO. Dos Santos Filho et al (2023) LOPES et al, 2022;PITCHAI et al, 2020;SANTOS FILHO et al, 2023;TAHA et al, 2021;VIJAYAKUMAR et al, 2018) Gostaríamos também de agradecer à Faculdade Catedral, localizada em Boa Vista, RR e à Secretaria de Educação do estado de Roraima, pela autorização para a realização deste trabalho.…”