Chemical Composition and Bioactivities of Essential Oil from Leaves of <i>Syzygium cumini</i> (L.) Skeels Native to Punjab, Pakistan

Hanif, Muhammad Usman; Hussain, Abdullah Ijaz; Aslam, Nosheen; Kamal, Ghulam Mustafa; Chatha, Shahzad Ali Shahid; Shahida, Shabnam; Khalid, Muhammad; Hussain, Riaz

doi:10.1002/cbdv.201900733

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…Other researches have registered inhibitory and bactericidal activity of the EOSC against S. aureus [ 35 ], the species was also susceptible to the extract of the seeds of S. cumini [ 36 ]. Against E. coli, the EOSC showed low inhibition when tested previously [ 37 ]. There was growth inhibition when the EOSC was tested against P. aeruginosa [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Analysis, Antibacterial Activity and Modulating Effect of Essential Oil from Syzygium cumini (L.) Skeels

et al. 2022

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One of the main global problems that affect human health is the development of bacterial resistance to different drugs. As a result, the growing number of multidrug-resistant pathogens has contributed to an increase in resistant infections and represents a public health problem. The present work seeks to investigate the chemical composition and antibacterial activity of the essential oil of Syzygium cumini leaves. To identify its chemical composition, gas chromatography coupled to mass spectrometry was used. The antibacterial activity test was performed with the standard strains Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 25853 and Staphylococcus aureus ATCC 25923 and multidrug-resistant clinical isolates E. coli 06, P. aeruginosa 24 and S. aureus 10. The minimum inhibitory concentration (MIC) was determined by serial microdilution as well as the verification of the modulating effect of the antibiotic effect. In this test, the oil was used in a subinhibitory concentration. The test reading was performed after 24 h of incubation at 37 °C. The results show that the major chemical constituent is α-pinene (53.21%). The oil showed moderate activity against E. coli ATCC 25922, with the MIC of 512 µg/mL; there was no activity against the other strains. The oil potentiated the effect of antibiotics demonstrating possible synergism when associated with gentamicin, erythromycin and norfloxacin against E. coli 06 and S. aureus 10.

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Section: Resultsmentioning

confidence: 99%

Phytochemical Analysis, Antibacterial Activity and Modulating Effect of Essential Oil from Syzygium cumini (L.) Skeels

et al. 2022

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“…An earlier investigation has reported the ethanol extract of leaves with MIC of 1.1 mg/ml against S. pyogenes and 2.1 mg/ml against E. coli. Excellent results were also reported against Aspergillus flavus (MIC 0.083 mg/ml) and Rhizopus solani (MIC 0.127 mg/ml) [38]. In another study, extracts of S. cumini with other Myrtaceae plants has displayed excellent synergism against the bacteria A. baumannii by decreasing the MIC value of an antibiotic, meropenem [39].…”

Section: Discussionmentioning

confidence: 85%

GC-MS Analysis and Antimicrobial Assessment of Syzygium cumini (L.) Skeels Seed Ethanol Extract

Parimala

Salomi

2021

JPRI

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People use plants to treat infections, and this has led to search of antimicrobials from medicinal plants. In this work, we evaluated the ethanol extract of Syzygium cumini seeds for their antibacterial and antifungal activities. Extraction was performed by maceration method using ethanol. The antimicrobial efficacy of the extract was assessed by agar well diffusion method against ten bacterial species, Bacillus cereus, Bacillus subtilis, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Serratia marcescens, Staphylococcus aureus and Streptococcus mutans, and five fungal species, Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger, Candida albicans and Mucor sp. Minimum inhibitory concentrations (MICs) of the extract were determined by resazurin microtiter plate assay. Phytochemicals in the extract was identified by gas chromatography mass spectrometry (GC-MS) information. In agar well diffusion method, Gram-negative bacteria such as P. aeruginosa and S. marcescens, Gram-positive bacteria such as B. subtilis and E. faecalis and fungi A. fumigatus were more susceptible showing larger zones of inhibition. In resazurin method, low MICs were recorded for bacteria, B. cereus (<7.8 µg) and P. aeruginosa (15.6 µg) and fungi, A. fumigatus (31.2 µg). Fifteen compounds were identified by GC-MS profiling of the extract. The antimicrobial activity of the extract can be rightly related to the secondary metabolites in the ethanol extract of Syzygium cumini seeds.

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“…The essential oil of S. cumini collected from India showed τ-cadinol and τ-muurolol to be the major compounds, followed by τ-globulol, caryophyllene, δ-cadinene, and α-pinene [24]. The collected S. cumini leaves from Pakistan revealed the major compounds to be β-farnesene, cis-β-ocimene, terpinen-4-ol, fenchol, β-myrcene, and γ-cadinene [25]. Another report revealed that the principal components of the essential oil isolated from S. jambos collected from Brazil to be (E)-caryophyllene, α-humulene, α-zingibirene, hydroxytoluene butylated, caryophyllene alcohol, caryolan-8-ol, caryophyllene oxide, thujopsan-2-α-ol, and n-heneicosane [26].…”

Section: Retention Timementioning

confidence: 96%

GC/MS Analysis of Essential Oil and Enzyme Inhibitory Activities of Syzygium cumini (Pamposia) Grown in Egypt: Chemical Characterization and Molecular Docking Studies

et al. 2021

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Syzygium cumini (Pomposia) is a well-known aromatic plant belonging to the family Myrtaceae, and has been reported for its various traditional and pharmacological potentials, such as its antioxidant, antimicrobial, anti-inflammatory, and antidiarrheal properties. The chemical composition of the leaf essential oil via gas chromatography–mass spectrometry (GC/MS) analysis revealed the identification of fifty-three compounds representing about 91.22% of the total oil. The identified oil was predominated by α-pinene (21.09%), followed by β-(E)-ocimene (11.80%), D-limonene (8.08%), β-pinene (7.33%), and α-terpineol (5.38%). The tested oil revealed a moderate cytotoxic effect against human liver cancer cells (HepG2) with an IC50 value of 38.15 ± 2.09 µg/mL. In addition, it effectively inhibited acetylcholinesterase with an IC50 value of 32.9 ± 2.1 µg/mL. Furthermore, it showed inhibitory properties against α-amylase and α-glucosidase with IC50 values of 57.80 ± 3.30 and 274.03 ± 12.37 µg/mL, respectively. The molecular docking studies revealed that (E)-β-caryophyllene, one of the major compounds, achieved the best docking scores of −6.75, −5.61, and −7.75 for acetylcholinesterase, α-amylase, and α-glucosidase, respectively. Thus, it is concluded that S. cumini oil should be considered as a food supplement for the elderly to enhance memory performance and for diabetic patients to control blood glucose.

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Chemical Composition and Bioactivities of Essential Oil from Leaves of Syzygium cumini (L.) Skeels Native to Punjab, Pakistan

Cited by 6 publications

References 32 publications

Phytochemical Analysis, Antibacterial Activity and Modulating Effect of Essential Oil from Syzygium cumini (L.) Skeels

Phytochemical Analysis, Antibacterial Activity and Modulating Effect of Essential Oil from Syzygium cumini (L.) Skeels

GC-MS Analysis and Antimicrobial Assessment of Syzygium cumini (L.) Skeels Seed Ethanol Extract

GC/MS Analysis of Essential Oil and Enzyme Inhibitory Activities of Syzygium cumini (Pamposia) Grown in Egypt: Chemical Characterization and Molecular Docking Studies

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