Chemical composition and antiparasitic activity of essential oils from leaves of<i>Guatteria friesiana</i>and<i>Guatteria pogonopus</i>(Annonaceae)

Meira, Cássio Santana; Menezes, Leociley Rocha Alencar; Santos, Tatiana B. dos; Macedo, Taís Soares; Fontes, José E. N.; Costa, Emmanoel V.; Pinheiro, Maria Lúcia B.; Silva, Thanany B. da; Guimarães, Elisalva Teixeira; Soares, Milena Botelho Pereira

doi:10.1080/10412905.2016.1210041

Cited by 18 publications

(13 citation statements)

References 20 publications

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“…The analysis of the result shown in Figure 3 and Table 4 revealed that the essential oil of C. verbenacea also presented values considered relevant, according to Meira et al [ 71 ], which considered relevant IC 50 values below 41.3 μg/mL, whereas the present study was 36.39 μg/mL. With regard to the epimastigote activity of the essential oil of this plant, this study is considered to have been pioneering.…”

Section: Discussionsupporting

confidence: 47%

Cytotoxicity of Essential Oil Cordia verbenaceae against Leishmania brasiliensis and Trypanosoma cruzi

et al. 2021

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The species Cordia verbenacea DC (Boraginaceae), known as the whaling herb and camaradinha, is a perennial shrub species native to the Atlantic Forest. Its leaves are used in folk medicine as an anti-inflammatory, analgesic, antiulcerogenic and curative agent, in the form of teas or infusions for internal or topical use. The present study aimed to verify the cytotoxicity of the essential oil and the leishmanicidal and trypanocidal potential of C. verbenacea. The essential oil was characterized by GC-MS. The in vitro biological activity was determined by anti-Leishmania and anti-Trypanosoma assays. The cytotoxixity was determined using mammalian fibroblasts. The C. verbenacea species presented α-pinene (45.71%), β-caryophyllene (18.77%), tricyclo[2,2,1-(2.6)]heptane (12.56%) as their main compounds. The essential oil exhibited strong cytotoxicity at concentrations below 250 μg/mL (LC50 138.1 μg/mL) in mammalian fibroblasts. The potent anti-trypanosome and anti-promastigote activities occurred from the concentration of 62.5 μg/mL and was considered clinically relevant. The results also demonstrate that at low concentrations (<62.5 μg/mL), the essential oil of C. verbenacea managed to be lethal for these activities. This can be considered an indication of the power used in daily human consumption. Therefore, it can be concluded that the essential oil of C. verbenacea contains a compound with remarkable antiparasitic activities and requires further research.

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Section: Discussionsupporting

confidence: 47%

Cytotoxicity of Essential Oil Cordia verbenaceae against Leishmania brasiliensis and Trypanosoma cruzi

et al. 2021

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“…Published studies have investigated the antiprotozoal and antibacterial activities of fixed and volatile constituents of species belonging to the Annonaceae family, e. g., B. multiflora , B. pleiosperma , D. lanceolata , G. australis , G. ferruginea , G. latifolia , G. sellowiana , G. friesiana , and G. pogonopus …”

Section: Introductionmentioning

confidence: 99%

In Vitro Trypanocidal and Antibacterial Activities of Essential Oils from Four Species of the Family Annonaceae

Bay

Oliveira

Sales

et al. 2019

Chemistry & Biodiversity

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The objective of this study was to evaluate the chemical composition, and the trypanocidal and antibacterial activities of the essential oils from four species of Annonaceae: Bocageopsis multiflora (Mart.) R.E.Fr., Duguetia quitarensis Benth., Fusaea longifolia (Aubl.) Saff., and Guatteria punctata (Aubl.) R.A.Howard. The chemical composition of the essential oils from the aerial parts yielded 23, 20, 21 and 23 constituents, respectively, which were identified by GC/MS. The trypanocidal activity was evaluated against the amastigote and trypomastigote forms of T. cruzi. The antibacterial activity was evaluated by the microdilution method against enterohemorrhagic Escherichia coli, Pseudomonas aeruginosa, Streptococcus mutans, Streptococcus pyogenes, and methicillin‐resistant Staphylococcus aureus. The results of trypanocidal activity showed that the essential oils of the four species were active at the tested concentrations, with G. punctata essential oil being the most active, with IC50=0.029 μg/mL, and selectivity index (SI)=32, being 34 times more active than the reference drug benznidazole. All EOs showed strong antibacterial activity (minimum inhibitory concentrations of 4.68–37.5 μg/mL) against strains of S. mutans.

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“…Essential oil of Guatteria spp., with β ‐eudesmol, γ ‐eudesmol, and α ‐eudesmol as main components, have shown trypanocidal effects on trypomastigotes and epimastigotes of T. cruzi , but this is the first report on their antiparasitic effects when tested alone. Sesquiterpenes from Tarchonanthus camphoratus and Schkuhria pinnata (parthenolide, 3‐oxo‐1,2‐dehydrocostic acid) with structural similarities to sesquiterpenes 1 – 20 showed activity against T. brucei , a clerodane diterpene (related to 13 ) from Polyalthia longifolia and a triterpenoid (with related chemical structure to compounds 33 and 34 ) from Eucalyptus maculata were active on Leishmania mexicana and Trypanosoma brucei .…”

Section: Resultsmentioning

confidence: 99%

Molecular Diversity from Arid‐Land Plants: Valorization of Terpenes and Biotransformation Products

Bailén

Martínez-Díaz

Hoffmann

et al. 2020

Chemistry & Biodiversity

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Asteraceae plants from arid lands are a source of biomass, resin and latex rich in terpenoids with diverse biological effects. Thirty‐six previously isolated terpenes, comprising sesquiterpenes, diterpenes, triterpenes and quassinoids, isolated from arid‐land plants and a series of metabolites from the biotransformation of some lead compounds were evaluated against insect pests (Spodoptera littoralis, Leptinotarsa decemlineata, Myzus persicae and Rhopalosiphum padi), cells (insect, hamster, murine and human tumoral cells) and parasites (Trypanosoma cruzi and Leishmania infantum). Among the insecticidal sesquiterpenes, maalian‐1α,8α‐diol (12) and γ‐eudesmol (17) were antifeedant against L. decemlineata, M. persicae and cytotoxic to Sf9 insect cells, and (−)‐maali‐3‐en‐8α‐ol (10), (+)‐maaliane‐5α,8α,9α‐triol (11), chrysothame (31) and holacanthone (35) were antifeedant against S. littoralis. The parasite L. infantum was slightly more sensitive than T. cruzi to the test compounds (39 % vs. 33 % of active compounds) with compound 17 and the biotransformed diterpene 27 being antiparasitic to L. infantum, with no cytotoxic effects on mammalian cells. Moreover, sesquiterpenes 3 and 17, and grindelane diterpenes 22, 23 and 26 showed selective activity against chemoresistant human colon, cervical and melanoma cancer cells. Thus, considering our results, the best candidates for future studies are compounds 17 and 3, due to their activity on insect pests, parasites (17) and tumoral cells (3, 17, 22, 23 and 26).

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Chemical composition and antiparasitic activity of essential oils from leaves ofGuatteria friesianaandGuatteria pogonopus(Annonaceae)

Cited by 18 publications

References 20 publications

Cytotoxicity of Essential Oil Cordia verbenaceae against Leishmania brasiliensis and Trypanosoma cruzi

Cytotoxicity of Essential Oil Cordia verbenaceae against Leishmania brasiliensis and Trypanosoma cruzi

In Vitro Trypanocidal and Antibacterial Activities of Essential Oils from Four Species of the Family Annonaceae

Molecular Diversity from Arid‐Land Plants: Valorization of Terpenes and Biotransformation Products

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