Chemical composition and antioxidant properties of γ-irradiated Iranian<i>Zataria multiflora</i>extracts

Fatemi, Faezeh; Asri, Younes; Rasooli, Iraj; Alipoor, Sh D; Shaterloo, M

doi:10.3109/13880209.2011.596208

Cited by 27 publications

(19 citation statements)

References 41 publications

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“…However, this compound was radiation-resistant in leaf EO from T. vulgaris [16]. In the same context, the content of carvacrol significantly decreased in aerial part EO from Z. multiflora [43] and increased at doses up to 5.0 kGy in the leaf EO from O. vulgare, whereas it was not affected by γ-radiation in leaf EO from T. vulgaris [16].…”

Section: Essential Oils From Overall Herbsmentioning

confidence: 89%

“…The content of thymol and carvacrol in a nonirradiated sample (61.8 and 10.5%, respectively) decreased for irradiated samples at 10.0 kGy (49.3 and 6.6%, respectively) and 25.0 kGy (45.3 and 6.3%, respectively). On the other hand, the content of p-cymene and γ-terpinene in a nonirradiated sample (7.5 and 4.4%, respectively) increased for irradiated samples at 10.0 kGy (16.2 and 8.6%, respectively) and 25.0 kGy (17.5 and 9.3%, respectively) [43]. [44].…”

Section: Essential Oils From Overall Herbsmentioning

confidence: 96%

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Effects of Gamma Radiation on Essential Oils: A Review

Araújo¹,

Corrêa²,

Abreu³

et al. 2017

New Insights on Gamma Rays

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Abstractγ-Radiation provides an effective alternative method to reduce or eliminate microbial contamination of medicinal herbs and other plant materials. However, a search in the literature is important to describe the effects of γ-radiation on the content and integrity of secondary metabolites from plants. The present work provides a review of the effects of γ-radiation on extraction yields and chemical composition of essential oils isolated from roots, rhizome and cortex, leaves, fruits, seeds, flowers, and whole plant. In addition, this review describes the effects of γ-radiation on terpenes. The informations in the present work may assist in research about essential oils and dose of γ-radiation that is able to biologically decontaminate without causing chemical changes in secondary metabolites. These reports in the literature can describe the behavior of many of these metabolites when subjected to various doses of radiation.

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Section: Essential Oils From Overall Herbsmentioning

confidence: 89%

Section: Essential Oils From Overall Herbsmentioning

confidence: 96%

Effects of Gamma Radiation on Essential Oils: A Review

Araújo¹,

Corrêa²,

Abreu³

et al. 2017

New Insights on Gamma Rays

View full text Add to dashboard Cite

show abstract

“…The essential oil extracted from Z. multiflora cultivated in Shiraz, Iran, exhibited in vitro antioxidant activity with major compounds such as thymol (61.8%), carvacrol (10.5%), p-cymene (7.5%), and γ-terpinene (4.4%) (Fatemi et al, 2012). However, in the present study, we effectively, for the first time, demonstrated the chemopreventive activity of Iranian Z. multiflora against DMH-induced colon carcinogenesis.…”

Section: Discussionmentioning

confidence: 37%

“…Alternatively, GST and GSH were induced, resulting in oxidative stress in cancer. Z. multiflora essential oils possess radical scavenging activity (Fatemi et al, 2012) causing decreased oxidative stress, which led to the reduction of GST induc tion (Toyokuni et al, 1995;Moghadasian et al, 1996). In addition, the GST overexpression augments the eicosonoid production, which is another common attribute in many tumors (Masotti et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

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Cancer chemopreventive effect of dietary Zataria multiflora essential oils

Dadkhah¹,

Fatemi²,

Malayeri³

et al. 2014

Turk J Biol

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Zataria multiflora Boiss., with the common name Avishan-e-Shirazi, is native to Iran. This herb has been found to possess varied pharmacological properties. In the present study, for the first time, colon chemopreventive effects of Z. multiflora essential oils (0.01% and 0.1% in the diet) in rats treated with 1,2-dimethylhydrazine (DMH) were demonstrated. For this purpose, the oxidative stress/antioxidant parameters (lipid peroxidation, glutathione, superoxide dismutase, catalase, and ferric reducing ability of plasma) concomitant with xenobiotic metabolizing enzymes (CYP450 and GST) were considered. Moreover, the colonic β-catenin protein was examined in colon tissues followed by histopathological analysis. The results showed that the dietary intervention of Z. multiflora oils in tumor-bearing rats induced with DMH caused significant modulatory effects on DMH-metabolizing enzymes, but with lack of oxidative stress/antioxidant status. In parallel, the elevated protein β-catenin induced by DMH decreased significantly in treatment groups. However, the decreased tumor formations in histopathological biopsies in treated groups further confirmed these results. Thus, with reference to histopathological and biochemical data, it can be safely concluded that inhibition of colon premalignant lesions induced by DMH was mediated by the interference of Z. multiflora oils through the modulatory effect of DMH-metabolizing enzymes in association with β-catenin and no impact of antioxidant/oxidative stress state.

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Effects of Lamiaceae family plants and their bioactive ingredients on coronavirus‐induced lung inflammation

Kianmehr,

Khazdair,

Abbasnezhad

et al. 2023

Food Science & Nutrition

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Coronaviruses (CoVs) are a family of viruses that cause infection in respiratory and intestinal systems. Different types of CoVs, those responsible for the SARS‐CoV and the new global pandemic of coronavirus disease 2019 in people, have been found. Some plants were used as food additives: spices and dietary and/or medicinal purposes in folk medicine. We aimed to provide evidence about possible effects of two Lamiaceae family plants on control or treatment of CoVs‐induced inflammation. The keywords including coronaviruses, Thymus vulgaris, Zataria multiflora, thymol, carvacrol, antivirus, and anti‐inflammatory and antioxidant effects were searched in various databases such as PubMed, Web of Sciences (ISI), and Google Scholar until September 2022. The medicinal herbs and their main ingredients, thymol and carvacrol, showed antiviral properties and reduced inflammatory mediators, including IL‐1β; IL‐6, and TNF‐α, at both gene and protein levels but increased the levels of IFN‐γ in the serum as anti‐inflammatory cytokine. These medicinal herbs and their constituents also reduce oxidative stress and enhance antioxidant capacity. The results of molecular docking analyses also indicated that polyphenol components such as thymol, carvone, and carvacrol could inhibit the entry of the viruses into the host cells in molecular docking analyses. The antiviral, anti‐inflammatory, and antioxidant effects of these plants may be due to actions of their phenolic compounds that modulate immune response and may be useful in the control and treatment of CoV‐induced lung disorder.

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Chemical composition and antioxidant properties of γ-irradiated IranianZataria multifloraextracts

Cited by 27 publications

References 41 publications

Effects of Gamma Radiation on Essential Oils: A Review

Effects of Gamma Radiation on Essential Oils: A Review

Cancer chemopreventive effect of dietary Zataria multiflora essential oils

Effects of Lamiaceae family plants and their bioactive ingredients on coronavirus‐induced lung inflammation

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