Chemical composition and antioxidant capacities of phytococktail extracts from trans-Himalayan cold desert

Dhar, Priyanka; Bajpai, Prabodh K.; Tayade, Amol B.; Chaurasia, O. P.; Srivastava, Ravi B.; Singh, Shashi Bala

doi:10.1186/1472-6882-13-259

Cited by 34 publications

(36 citation statements)

References 48 publications

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“…Strong positive correlations were found among the antioxidant capacity assays (ABTS, DPPH, β-carotene-linoleic acid bleaching, nitric oxide, FRAP) and phenolic contents (TPAC, TFC, TPC) in all lichen extracts. Therefore, in agreement with previous reports, the results on correlations of different antioxidant assays and total phenolic content have demonstrated that the antioxidant capacity of the lichen extracts was positively associated with total phenolic content [33], [34], [78], [79], [84]. Thus, the present study highlights the antioxidant capacities rendered by the lichen extracts under oxidative stress.…”

Section: Discussionsupporting

confidence: 93%

Antioxidant Capacities, Phenolic Profile and Cytotoxic Effects of Saxicolous Lichens from Trans-Himalayan Cold Desert of Ladakh

et al. 2014

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Fourteen saxicolous lichens from trans-Himalayan Ladakh region were identified by morpho-anatomical and chemical characteristics. The n-hexane, methanol and water extracts of the lichens were evaluated for their antioxidant capacities. The lichen extracts showing high antioxidant capacities and rich phenolic content were further investigated to determine their cytotoxic activity on human HepG2 and RKO carcinoma cell lines. The ferric reducing antioxidant power (FRAP), 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), 1,1-diphenyl-2-picrylhydrazyl (DPPH) and nitric oxide (NO) radical scavenging capacities and β-carotene-linoleic acid bleaching property exhibited analogous results where the lichen extracts showed high antioxidant action. The lichen extracts were also found to possess good amount of total proanthocyanidin, flavonoid and polyphenol. The methanolic extract of Lobothallia alphoplaca exhibited highest FRAP value. Methanolic extract of Xanthoparmelia stenophylla showed the highest ABTS radical scavenging capacity. The n-hexane extract of Rhizoplaca chrysoleuca exhibited highest DPPH radical scavenging capacity. Highest antioxidant capacity in terms of β-carotene linoleic acid bleaching property was observed in the water extract of Xanthoria elegans. Similarly, Melanelia disjuncta water extract showed highest NO scavenging capacity. Among n-hexane, methanol and water extracts of all lichens, the methanolic extract of Xanthoparmelia mexicana showed highest total proanthocyanidin, flavonoid and polyphenol content. From cytotoxic assay, it was observed that the methanolic extracts of L. alphoplaca and M. disjuncta were exhibiting high cytotoxic effects against cancer cell growth. Similarly, the water extract of Dermatocarpon vellereum, Umbilicaria vellea, X. elegans and M. disjuncta and the methanolic extract of M. disjuncta and X. stenophylla were found to possess high antioxidant capacities and were non-toxic and may be used as natural antioxidants for stress related problems. Our studies go on to prove that the unique trans-Himalayan lichens are a hitherto untapped bioresource with immense potential for discovery of new chemical entities, and this biodiversity needs to be tapped sustainably.

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Section: Discussionsupporting

confidence: 93%

Antioxidant Capacities, Phenolic Profile and Cytotoxic Effects of Saxicolous Lichens from Trans-Himalayan Cold Desert of Ladakh

et al. 2014

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“…2124 Previous study also reports that secondary metabolites act as strong chain breaking antioxidants. 23 Our results are in accordance with Mann et al 25 using a comparative nutritional and antioxidant potential of two in the bran. 13 reported the Mo/Ni/P/Co/Cu/Fe/Zn and Mn in extract of buckwheat flour.…”

Section: Total Phenol and Flavonoid Contentsupporting

confidence: 93%

Antioxidant Potential and Ionomic Analysis of Two Buckwheat Species from Kashmir Region

Pirzadah¹,

Malik²,

Tahir³

et al. 2018

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Background: Buckwheat in the past had been the staple food for many regions in the Himalaya's and its utilization has declined with time. In recent times buckwheat gained a lot of attention as it has been placed in the list of underutilized crops by FAO. There is a strong sentiment and realization for buckwheat revival because of its nutraceutrical properties due to which it provides the consumers with extra choice for his food basket. In this context the present investigation aimed to evaluate the antioxidant potential and mineral element analysis of two buckwheat species grown in Kashmir region. Methods: To achieve this goal, antioxidant potential of two buckwheat species was done by using standard protocols. For ionomic analysis, atomic absorption spectrophotometry (AAS) was done to unravel the macro-and micro-nutrient composition. Result: Aqueous extract of Fagopyrum tataricum exhibits higher TPC (159.51±10.3 mg gallic acid equivalent g -1 DW) and TFC (79.49±9.76 mg rutin equivalent g -1 DW). The F. tataricum samples exhibit high radical scavenging activity (RS a50 =26.67µg ml -1 ) as compared to F. kashmirianum (RS a50 =34.15µg ml -1 ). Elemental analysis revealed that calcium (Ca) was found high in F. tataricum (5125±56.76ppm) while as the iron (Fe) and zinc (Zn) were found in high concentration in F. kashmirianum (1122.5±25.77ppm) and (122.75±12.34ppm) respectively. Conclusion: These findings suggested that buckwheat extract possess excellent antioxidant property and is rich source of minerals indispensable for human health. Thus, buckwheat could be a promising alternative in functional food sector for improving the social well-being and diminishing malnutrition especially for the impoverished community.

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“…The ABTS+ scavenging capacity of the extract was compared with that of BHT and percentage inhibition was calculated using the same equation as that for DPPH method. 12 …”

Section: Abts (22'-azino-bis(3-ethylbenzthiazoline-6-sulphonic Acid)mentioning

confidence: 99%

Free Radical Scavenging and Cytotoxic Potential of Celosia argentea

Rub¹,

Patil²,

Siddiqui³

et al. 2015

Phcog J

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Introduction: Oxidative stress due to reactive oxygen species often leads to pathogenesis of chronic diseases such as cancer. Research states that a diet rich in polyphenols renders many health benefits by scavenging such harmful reactive species. Celosia argentea (Amaranthaceae), a common weed in India has been reported as a potential source of cheap, natural antioxidants due to its phenolic abundance. In this research work efforts were made to identify and screen the phenolic rich fractions of Celosia argentea for their antioxidant and anticancer potential. Materials and Methods: Various solvent fractions with increasing polarity were subjected to total phenolic content, followed by antioxidant assays-DPPH, ABTS and anti proliferative assays-Brine shrimp Bioassay, Antimitotic and MTT assays.

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Chemical composition and antioxidant capacities of phytococktail extracts from trans-Himalayan cold desert

Cited by 34 publications

References 48 publications

Antioxidant Capacities, Phenolic Profile and Cytotoxic Effects of Saxicolous Lichens from Trans-Himalayan Cold Desert of Ladakh

Antioxidant Capacities, Phenolic Profile and Cytotoxic Effects of Saxicolous Lichens from Trans-Himalayan Cold Desert of Ladakh

Antioxidant Potential and Ionomic Analysis of Two Buckwheat Species from Kashmir Region

Free Radical Scavenging and Cytotoxic Potential of Celosia argentea

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