Chemical composition and antimicrobial activity of essential oil of Ferula szovitsiana D.C.

Abstract

The chemical composition of the essential oils obtained from stem/leaves and flowers/fruits of Ferula szovitsiana (Umbelliferae) were analysed by GC and GC-MS. The composition of the oils samples from stem/leaves and flower/fruits were compared: 51 and 47 compounds were identified in the essential oils of stem/leaves and flowers/ fruits, representing 97.7% and 95.9% of the total oils, respectively. Both essential oils were rich in monoterpenes (66.7% and 62.1%, respectively) with neryl acetate as major component (33.0% and 41.5%, respectively). Other abundant compounds for stem/leaves oil were β β β β β-caryophyllene (8.9%), α α α α α-pinene (8.0%), β β β β β -pinene (6.7%), bicyclogermacrene (4.5%), caryophyllene oxide (4.1%), limonene (4.6%) and α α α α α-terpineol (3.2%). These values for flowers/fruits oil were bicyclogermacrene (9.0%), α α α α α-pinene (5.5%), β β β β β -pinene (3.9%), γ γ γ γ γ -cadinene (3.5%), and calarene (3.2%). Furthermore, the oils were tested against Gram-positive, Gram-negative bacteria and two pathogenic fungi. It was found that oil from F. szovitsiana represents the most potent antimicrobial candidates with MIC of 1.25 mg/disk for Bacillus subtilis. Copyright

Novel thermosensitive poly (N-isopropylacrylamide-co-vinylpyrrolidone-co-methacrylic acid) nanosystems for delivery of natural products.

“…This distinct peak displays a constant characteristic of the coumarin structure. These data are in consensus with the results reported previously [21,3].…”

“…The fractions were compared by TLC (silica gel using petroleum ether-EtOAc as solvent), and those giving similar coumarin spots were combined and further purified on preparative TLC to give Farnesiferol C (5.43 mg). The melting point, H-and C-NMR data of the obtained isolated farnesifeol C were confirmed according to previously published works [21,22,23].…”

“…Given the integration of nanomaterials with herbal medicine for providing more efficient medications, we focused on exploitation of bioactive derivatives from plant resources that provide huge potential for novel biologically active compounds such as antiinflammatory, anticancer, antiviral, antibacterial, and antioxidant agents. Ferula genus from Umbelliferae family, which is naturally distributed throughout the Mediterranean to Central Asia [21,22,3], seems to confer interesting bioactivities. In our preliminary investigation, we have found some non-polar fractions from a chloroform extract of ferula szowitsiana roots, which were examined for its anticancer activities using several human cancer cell lines by means of the routinely used MTT assay (our unpublished data).…”

“…In our preliminary investigation, we have found some non-polar fractions from a chloroform extract of ferula szowitsiana roots, which were examined for its anticancer activities using several human cancer cell lines by means of the routinely used MTT assay (our unpublished data). Similarly, , recruiting acridine orange/Ethidium bromide double staining methodology, reported the induction of caspase-3 activities leading to apoptosis in the ht-29 cells treated with Farnesiferol C. intriguingly, the morphological studies showed chromatin condensation and detaching of adherent cells treated with chloroform extract and fractions of Farnesiferol C, resulting in profound inhibition of the cell proliferation in human cancer cell lines perhaps through induction of apoptosis [28,21,22,4]. The relatively high cytotoxic potential Farnesiferol C directed us to formulate it as a nano-scaled product using biodegradable polymers to maximize its biological impact.…”

Chemotaxonomic Significance of the Essential Oils of 18 Ferula Species (Apiaceae) from Iran

“…In this respect, the essential oil of another sample of F. ovina in the flowering stage [19], with a-pinene as the main compound, resembles those of the four samples analyzed in the present study. In the case of F. szowitsiana, the essential oils obtained from different plant parts have been shown to expose different profiles [25] [26], but the essential oil obtained from the aerial parts of a sample collected from another location in Iran [27] exhibited more resemblance to our sample ( Table 3). In the essential oil of F. szowitsiana originating from Turkey, which was isolated from the leaves and stems alone, b-eudesmol and a-eudesmol were characterized as main components [25].…”