Chemical composition and antimicrobial activity of Congea tomentosa, an ethnomedicinal plant from Bangladesh

Faruque, Mohammad Omar; Ankhi, Umme Ruman; Kamaruzzaman, M.; Barlow, James W.; Zhou, Bo; Jiang, Hao; Yang, Xinzhou; Hu, Xuebo

doi:10.1016/j.indcrop.2019.111745

Cited by 12 publications

(14 citation statements)

References 43 publications

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“…The search for a single highly bioactive compound does not adequately consider the interaction of the intricate and concatenated network of secondary metabolites present in medicinal plants [ 22 ]. Antimicrobial activity is a good example in this context, since plants are composed of complex phytochemical pools of compound combinations designed to fight infections, and often molecules isolated from plant sources have exhibited lower antimicrobial activities compared to the whole extracts [ 23 , 24 ]. However, the study of plant extracts remains inherently complex and is often exacerbated by rampant variation due to genetic traits and/or environmental factors that influence the production of secondary metabolites by plants.…”

Section: Introductionmentioning

confidence: 99%

Unravelling the Antibacterial Activity of Terminalia sericea Root Bark through a Metabolomic Approach

et al. 2020

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Terminalia sericea Burch. ex. DC. (Combretaceae) is a popular remedy for the treatment of infectious diseases. It is widely prescribed by traditional healers and sold at informal markets and may be a good candidate for commercialisation. For this to be realised, a thorough phytochemical and bioactivity profile is required to identify constituents that may be associated with the antibacterial activity and hence the quality of raw materials and consumer products. The aim of this study was to explore the phytochemistry and identify the antibacterial constituents of T. sericea root bark, using a metabolomic approach. The chemical profiles and antibacterial activities of 42 root bark samples collected from three districts in the Limpopo Province, South Africa, were evaluated. Dichloromethane:methanol (1:1) extracts were analysed using ultraperformance liquid chromatography (UPLC)-mass spectrometry (MS), and chemometric models were constructed from the aligned data. The extracts were tested against Bacillus cereus (ATCC 11778), Staphylococcus epidermidis (ATCC 12223), Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 8739), Klebsiella pneumoniae (ATCC 13883), Pseudomonas aeruginosa (ATCC 27853), Shigella sonnei (ATCC 9292) and Salmonella typhimurium (ATCC 14028), using the minimum inhibition microdilution assay. Nine compounds; sericic acid, sericoside, resveratrol-3-O-β-rutinoside, ellagic acid, flavogallonic acid dilactone, methyl-flavogallonate, quercetin-3-(2′′-galloylrhamnoside), resveratrol-3-(6′′-galloyl)-O-β-d-glucopyranoside and arjunetin, were isolated from the root bark. All the compounds, with the exception of sericic acid, sericoside and resveratrol-3-O-β-rutinoside, were isolated for the first time from the root bark of T. sericea. Chemometric analysis revealed clustering that was not population specific, and the presence of three groupings within the samples, characterised by sericic acid, sericoside and an unidentified compound (m/z 682/4.66 min), respectively. The crude extracts from different populations displayed varied antibacterial activities against S. typhimurium (minimum inhibitory concentrations (MICs) 0.25–1.0 mg/mL), but similar activity towards Bacillus cereus (1.0 mg/mL). Several compounds present in the root bark were highly active towards all or most of the pathogens tested, but this activity was not reflected by the chemical profiles of extracts prepared from the individual samples. Among the pure compounds tested, only flavogallonic acid dilactone and methyl-flavogallonate exhibited broad-spectrum activity. A biochemometric analysis indicated that there was no consistent association between the levels of phytochemicals and the activity of the active or non-active extracts. Although it was deduced that the major constituents of T. sericea root bark contributed to the chemotypic variation, further investigation of the interactions of compounds present in the root bark may provide antibacterial efficacies not evident when examining compounds singularly. The data reported herein will provide information that is fundamentally important for the development of quality control protocols.

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Section: Introductionmentioning

confidence: 99%

Unravelling the Antibacterial Activity of Terminalia sericea Root Bark through a Metabolomic Approach

et al. 2020

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“…Recently, the antibacterial activity of pure compounds isolated from plant extracts has been reported. e potency of stigmasterol, an isolate of ethyl acetate fraction of Congea tomentosa stem against the growth of Aspergillus flavus, Aspergillus niger, Bacillus subtilis, Escherichia coli, Penicillium digitatum, and Serratia liquefaciens, has been reported [176]. Similarly, dalpanitin and vicenin-3 isolated from ethyl acetate fraction of Derris scandens leaves effectively inhibited the growth of Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa, and E. coli [177].…”

Section: Antimicrobial Preservatives Several Plant Extractsmentioning

confidence: 97%

“…is gives them the ability to replace the hormone, thus disrupting the cell membrane. In the same vein, certain steroids suppress the ability of certain microbes to resist antibiotics by disrupting the multiple drug efflux pump proteins in multidrug-resistant microbes [176,219]. e presence of vinyl and peroxide moiety in steroids leads to an enhanced antibacterial activity [176,220].…”

Section: Antimicrobial Preservatives Several Plant Extractsmentioning

confidence: 99%

“…In the same vein, certain steroids suppress the ability of certain microbes to resist antibiotics by disrupting the multiple drug efflux pump proteins in multidrug-resistant microbes [176,219]. e presence of vinyl and peroxide moiety in steroids leads to an enhanced antibacterial activity [176,220]. A different mechanism of action has been observed for different types of alkaloids.…”

Section: Antimicrobial Preservatives Several Plant Extractsmentioning

confidence: 99%

“…Hence, isolation of the active compounds which exert the antimicrobial/antioxidant activity helps to eradicate the toxic compounds, which are not needed in such therapeutic mixtures. ough the process of fractionating and isolating these bioactive compounds are often expensive, energy, and time consuming [273]; bioassay-guided fractionation of active compound is advised to reduce the complication that might arise [176,177,198,213].…”

Section: Toxicity Effect Of Unrefined Crude Extractsmentioning

confidence: 99%

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Promising Natural Products in Crop Protection and Food Preservation: Basis, Advances, and Future Prospects

Ogunnupebi

Oluyori

Dada

et al. 2020

International Journal of Agronomy

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The increase in demand for agricultural produce necessitates the continuous search for affordable, ecofriendly, readily available crop protectors, and food preservatives. Historically, the use of various chemicals was employed in controlling plant diseases and to maintain food quality. In the past few decades, several natural product-based alternatives have been discovered and projected as better alternatives to synthetic pesticides and other synthetic agrochemicals. Recent studies focusing on the application of different botanicals in crop protection and food preservation were carefully selected and reviewed. The application of plant extract in the biogenic preparation of nanoparticles was also reviewed. This review confirms that several natural products can be used as a safe replacement for synthetic agrochemicals. Different plant extracts have also served as feed for the synthesis of nanoparticle, which is increasingly applicable in crop protection and food preservation.

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Anticancer and Apoptotic Effects of Hymenodictyon floribundum (Hochst. & Steud.) B.L.Rob. Stem Bark Hydroethanolic Extract

Moyo,

Jagadhane,

Bhosale

et al. 2023

Chemistry Africa

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Chemical composition and antimicrobial activity of Congea tomentosa, an ethnomedicinal plant from Bangladesh

Cited by 12 publications

References 43 publications

Unravelling the Antibacterial Activity of Terminalia sericea Root Bark through a Metabolomic Approach

Unravelling the Antibacterial Activity of Terminalia sericea Root Bark through a Metabolomic Approach

Promising Natural Products in Crop Protection and Food Preservation: Basis, Advances, and Future Prospects

Anticancer and Apoptotic Effects of Hymenodictyon floribundum (Hochst. & Steud.) B.L.Rob. Stem Bark Hydroethanolic Extract

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