Chemical Composition and Antimicrobial Activities of the Essential Oil From Salvia mirzayanii Leaves

Abstract

Resistance of many pathogens to available drugs is a global challenge and is leading to growing interest in natural alternative products. In this study, chemical composition and in vitro antibacterial and antifungal activities of the essential oil from Salvia mirzayanii were investigated. The chemical constituents of essential oil from S mirzayanii were analyzed by gas chromatography–mass spectrometry. The antimicrobial activity was determined by broth microdilution. The main identified compounds were 1,8-cineole (41.2 ± 1.3%), linalool acetate (11.0 ± 0.5%), and α-terpinyl acetate (6.0 ± 0.4%) (mL of essential oil/g of plant material). The MIC95 were 0.03 to 0.5 µL/mL and 16 to 128 µL/mL for gram-positive and gram-negative bacteria, respectively. These results indicated that Salvia mirzayanii essential oil significantly inhibited the growth of standard and clinically isolated tested yeasts by MIC50 0.03 to 1 µL/mL. Potent antibacterial and antifungal activities of Salvia mirzayanii essential oil may be considered in future study, particularly against antibiotic-resistant cases.

Antimicrobial Activity and Proposed Action Mechanism of Linalool Against Pseudomonas fluorescens

“…The results from the measurement of MIC and MBC, followed by the growth curve indicated that linalool had strong and consistent inhibiting effects on P. fluorescens ( Figure 1 ). EOs (from Litsea cubeba leaf, Salvia mirzayanii, Zataria multiflora, Gnaphlium affine, Forsythia koreana ) affect the structure of the cell envelope because it was found that the major antibacterial compositions of the EOs could penetrate through the cell wall and destroy the cytoplasmic membrane ( Zeng et al, 2011 ; Kavoosi and Rabiei, 2015 ; Yang et al, 2015 ; Zomorodian et al, 2017 ; Nguyen et al, 2018 ). Scanning electron microscope (SEM) results showed that the cell morphology changed after linalool treatment ( Figure 2 ).…”

Retracted: Antibacterial activity and mechanism of Tetrapleura tetraptera stem extract against Salmonella strains and its application in raw chicken meat

“…The initial column temperature was 60°C for 2 min. Then raised to 250°C at 2/min and held for 5 min (Zomorodian, Moein, Pakshir, Karami, & Sabahi, 2017).…”

Chemical Composition and Antimicrobial Effectiveness of Ocimum gratissimum L. Essential Oil Against Multidrug-Resistant Isolates of Staphylococcus aureus and Escherichia coli

“…Many studies have documented EOs to be effective antimicrobial agents against several pathogens [14][15][16]. Usually, this EO effect is closely related to the capability of permeabilizing and/or destroying membrane integrity, leading to the leakage of intracellular substances [17][18][19]. Moreover, since the last decade, the antibiofilm activity of EOs has been widely explored and reported in the literature [20][21][22][23].…”