Chemical composition and antifungal activity of Chelidonium majus extracts – antagonistic action of chelerythrine and sanguinarine against Botrytis cinerea

The Cultivation of Chelidonium majus L. Increased the Total Alkaloid Content and Cytotoxic Activity Compared with Those of Wild-Grown Plants

“…The identities of chelidonine, sanguinarine, and chelerythrine were confirmed with available reference standards. Tentative identification of other alkaloids was performed by comparison of their chromatographic retention times and detected m/z values with literature data [ 19 , 25 ]. A summary of the identification results is shown in Table 1 .…”

“…Coptisine, as the predominant alkaloid, was also found by Sárközi et al [ 21 ]; however, the extracts in their study were prepared using methylene chloride. Chelerythrine and sanguinarine were found to be the dominant alkaloids in methanol extracts [ 19 ]. In aqueous ethanol extracts, coptisine was found to be the dominant alkaloid; moreover, an increase in ethanol content from 25% to 45% resulted in a more than fivefold increase in coptisine recovery [ 26 ].…”

“… 1 [ 19 ], 2 overlapping chromatographic signals, 3 [ 25 ], bold —identified by comparison with reference compounds. …”

“…Comprehensive reports on the alkaloid profile of C. majus [ 16 , 17 , 18 , 19 ] are available. More than 50 alkaloids have been detected in greater celandine [ 17 , 20 ].…”

“…More than 50 alkaloids have been detected in greater celandine [ 17 , 20 ]. Quantitative analyses of the main alkaloids chelerythrine, sanguinarine, and coptisine in C. majus extracts were performed by HPLC-DAD and LC–MS/MS, and tentative identification of minor alkaloids was performed with data from the literature [ 16 , 19 , 21 , 22 , 23 ]. In contrast, data on flavonoid composition and content in C. majus are fragmented and mainly qualitative.…”