Chemical Composition and Antibacterial Activity of the Essential Oil from Whole Aerial Parts of<i>Leucas mollissima</i>Wall. ex Benth

Prasad, Rajendra; Bisht, Lalit; Joshi, Deepshikha; Nailwal, Manoj; Melkani, Anand B.

doi:10.1080/0972060x.2016.1262791

Cited by 1 publication

(2 citation statements)

References 9 publications

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“…Studies have shown that essential oils containing valencene as a principal constituent have significant antimicrobial activity [49][50][51][52][53][54]. A study with the essential oil of the leaves and flowers of Vitex negundo showed that both had valencene in their composition.…”

Section: Efflux Pump Inhibition Through Etbr Fluorescence Emissionmentioning

confidence: 99%

“…Valencene's binding solid affinity was demonstrated so that sesquiterpene showed more significant interaction with S. aureus, with binding affinity ranging from 5.1 to 7.7 kcal/mol [51]. Other species whose antibacterial activity was associated with the presence of valencene include Leucas molissima [52], Salvia tomentosa [53], and Piper nigrum, highlighting the pharmacological potential of this terpene against a vast number of bacterial strains [54]. Nevertheless, few studies have evaluated the biological activity of isolated valencene, and, therefore, this study is a pioneer in assessing the effect of this compound against strains of S. aureus carrying efflux pumps.…”

Section: Efflux Pump Inhibition Through Etbr Fluorescence Emissionmentioning

confidence: 99%

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Valencene, Nootkatone and Their Liposomal Nanoformulations as Potential Inhibitors of NorA, Tet(K), MsrA, and MepA Efflux Pumps in Staphylococcus aureus Strains

Oliveira-Tintino,

Santana,

Alencar

et al. 2023

Pharmaceutics

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Valencene and nootkatone are aromatic sesquiterpenes with known biological activities, such as antimicrobial, antioxidant, anti-inflammatory, and antitumor. Given the evidence that encapsulation into nanosystems, such as liposomes, could improve the properties of several compounds, the present study aimed to evaluate the activity of these sesquiterpenes in their isolated state or in liposomal formulations against strains of Staphylococcus aureus carrying efflux pumps. The broth microdilution method evaluated the antibiotic-enhancing activity associated with antibiotics and ethidium bromide (EtBr). The minimum inhibitory concentration was assessed in strains of S. aureus 1199B, IS-58, and RN4220, which carry the efflux proteins NorA, Tet(K), and MsrA. In tests with strain 1199B, valencene reduced the MIC of norfloxacin and EtBr by 50%, while the liposomal formulation of this compound did not show a significant effect. Regarding the strain IS-58, valencene, and its nanoformulation reduced norfloxacin MIC by 60.3% and 50%, respectively. In the non-liposomal form, the sesquiterpene reduced the MIC of EtBr by 90%. Against the RN4220 strain, valencene reduced the MIC of the antibiotic and EtBr by 99% and 93.7%, respectively. Nootkatone and its nanoformulation showed significant activity against the 1199B strain, reducing the EtBr MIC by 21.9%. Against the IS-58 strain, isolated nootkatone reduced the EtBr MIC by 20%. The results indicate that valencene and nootkatone potentiate the action of antibiotics and efflux inhibitors in strains carrying NorA, Tet(K), and MsrA proteins, which suggests that these sesquiterpenes act as efflux pump inhibitors in S. aureus. Therefore, further studies are needed to assess the impact of incorporation into liposomes on the activity of these compounds in vivo.

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Section: Efflux Pump Inhibition Through Etbr Fluorescence Emissionmentioning

confidence: 99%

Section: Efflux Pump Inhibition Through Etbr Fluorescence Emissionmentioning

confidence: 99%

Valencene, Nootkatone and Their Liposomal Nanoformulations as Potential Inhibitors of NorA, Tet(K), MsrA, and MepA Efflux Pumps in Staphylococcus aureus Strains

Oliveira-Tintino,

Santana,

Alencar

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

show abstract

Chemical Composition and Antibacterial Activity of the Essential Oil from Whole Aerial Parts ofLeucas mollissimaWall. ex Benth

Cited by 1 publication

References 9 publications

Valencene, Nootkatone and Their Liposomal Nanoformulations as Potential Inhibitors of NorA, Tet(K), MsrA, and MepA Efflux Pumps in Staphylococcus aureus Strains

Valencene, Nootkatone and Their Liposomal Nanoformulations as Potential Inhibitors of NorA, Tet(K), MsrA, and MepA Efflux Pumps in Staphylococcus aureus Strains

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