Chemical Composition and Anti-inflammatory Activity of Algerian <i>Thymus vulgaris</i> Essential Oil

Abdelli, Wafae; Bahri, Fouad; Romane, Abderrahmane; Höferl, Martina; Wanner, Juergen; Schmidt, Erich; Jirovetz, Leopold

doi:10.1177/1934578x1701200435

Cited by 27 publications

(24 citation statements)

References 24 publications

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“…Our findings corroborated those for T. vulgaris from Chlef (Northwestern Algeria), that identified carvacrol as the major component (48.4%) (16). However, in our previous study in the same plant harvested from the same regions in May 2014, both oils (EO.TM and EO.TT) were predominated by thymol (59.5 and 67.3%, respectively) (17).…”

Section: Discussionmentioning

confidence: 67%

Chemical composition, antimicrobial and cytotoxic activity of essential oils of Algerian Thymus vulgaris L.

Abdelli¹,

Sysak²,

Bahri³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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Antimicrobial drugs are highly popular in the treatment of infectious diseases and particularly nosocomial infections. However, excessive microbial exposure to drugs has become the most important factor triggering the emergence and spread of multidrug resistance (MDR) of microorganisms (1). This phenomenon has become a pressing global problem for two reasons. Firstly, it increases morbidity and mortality rates and treatment costs. Secondly, it limits the effectiveness of existing drugs and enhances the number of treatment failures (2). Furthermore, in the last few decades, cancer has become one of the most fiercely combated diseases around the world (3). Synthetic drugs are often the only option for cancer chemotherapy (4). However, most of them kill not only tumor cells but also the normal ones (5). Therefore, there is an urgent need for new treatments with few side effects. The use of medicinal plants and especially their secondary metabolites, essential oils (EOs), may pose a viable alternative. Thymus vulgaris L., known as common thyme (Lamiaceae family), is a perennial herb indigenous to the Mediterranean region, Asia, Southern Europe and North Africa (6). It is widely used in folk medicine and also in the food industry as a spice and natural preservative. Its oil is among the top 10 EOs exhibiting various biological activities (7) mainly due to phenols, e.g. thymol and carvacrol (8). This considerable potential of thyme oil encouraged us to analyze its chemical structure by GC-FID and GC-MS and verify its antimicrobial activity against seven reference strains responsible for nosocomial infections. We also assessed its cyto

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Section: Discussionmentioning

confidence: 67%

Chemical composition, antimicrobial and cytotoxic activity of essential oils of Algerian Thymus vulgaris L.

Abdelli¹,

Sysak²,

Bahri³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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“…In an in vivo study, Abdelli et al (2017) analysed thyme oil in a dose dependent manner (100, 200 and 400 mg/kg) against mice with carrageenan-induced paw edema to determine the anti-inflammatory activity. Paw thickness was found reducing at a dose of 400 mg/kg.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

A systematic review on ethnopharmacology, phytochemistry and pharmacological aspects of Thymus vulgaris Linn.

Patil

Ramu

Shirahatti³

et al. 2021

Heliyon

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Thymus vulgaris Linn. is a medicinal and culinary herb from the Southern European region known for its antiinfective, cardioprotective, gastroprotective, anti-inflammatory, and immunomodulatory activities since the Egyptian era. The reported pharmacological activities of T. vulgaris L. include antibacterial, antioxidant, antiinflammatory, antiviral, and anti-cancerous activities. In this review, a comprehensive approach is put forth to scrutinize and report the available data on phytochemistry, ethnopharmacology, pharmacology, and toxicology of the plant. The different extracts and essential oil obtained from the plant have been assessed and reported to treat ailments like microbial infections, inflammation, non-communicable diseases like cancer, and sexually transmitted diseases like HIV-1 and Herpes. The literature review has also indicated the use of volatile oils, phenolic acids, terpenoids, flavonoids, saponins, steroids, tannins, alkaloids, and polysaccharides in pharmacotherapy. Applications of these compounds including antidiabetic, anti-Alzheimer's, cardio, neuro and hepatoprotective, anti-osteoporosis, sedative, immunomodulatory, antioxidant, anti-tyrosinase, antispasmodic, antinociceptive, gastroprotective, anticonvulsant, antihypertensive, antidepressant, anti-amnesia, and anti-helminthic activities have been mentioned. Further, based on research gaps, recommendations have been provided to evaluate T. vulgaris L. systematically to develop plant-based drugs, nutraceuticals, and to evaluate their clinical efficiency and safety.

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“…Thymus vulgaris L. (Lamiaceae) is an aromatic plant whose essential oil already has various pharmacological activities described such as antimicrobial [91], anthelmintic [92] and anti-inflammatory [93]. The GC-MS analysis of Thymus vulgaris essential oil (TVEO) revealed the presence of more than 50 metabolites.…”

Section: Thymus Vulgaris Lmentioning

confidence: 99%

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

et al. 2019

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Epilepsy is a most disabling neurological disorder affecting all age groups. Among the various mechanisms that may result in epilepsy, neuronal hyperexcitability and oxidative injury produced by an excessive formation of free radicals may play a role in the development of this pathology. Therefore, new treatment approaches are needed to address resistant conditions that do not respond fully to current antiepileptic drugs. This paper reviews studies on the anticonvulsant activities of essential oils and their chemical constituents. Data from studies published from January 2011 to December 2018 was selected from the PubMed database for examination. The bioactivity of 19 essential oils and 16 constituents is described. Apiaceae and Lamiaceae were the most promising botanical families due to the largest number of reports about plant species from these families that produce anticonvulsant essential oils. Among the evaluated compounds, β-caryophyllene, borneol, eugenol and nerolidol were the constituents that presented antioxidant properties related to anticonvulsant action. These data show the potential of these natural products as health promoting agents and use against various types of seizure disorders. Their properties on oxidative stress may contribute to the control of this neurological condition. However, further studies on the toxicological profile and mechanism of action of essential oils are needed.

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Chemical Composition and Anti-inflammatory Activity of Algerian Thymus vulgaris Essential Oil

Cited by 27 publications

References 24 publications

Chemical composition, antimicrobial and cytotoxic activity of essential oils of Algerian Thymus vulgaris L.

Chemical composition, antimicrobial and cytotoxic activity of essential oils of Algerian Thymus vulgaris L.

A systematic review on ethnopharmacology, phytochemistry and pharmacological aspects of Thymus vulgaris Linn.

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

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