Chemical Composition and Anti‐Alzheimer's Disease‐Related Activities of a Functional Oil from the Edible Seaweed <i>Hizikia fusiforme</i>

Yang, Wencong; Zhang, Yuanyuan; Li, Yajuan; Nie, Yingying; Liang, Jinyue; Liu, Yayue; Liu, Jingshan; Zhang, Yongping; Song, Cai; Qian, Zhong‐Ji; Zhang, Yi

doi:10.1002/cbdv.202000055

Cited by 13 publications

(15 citation statements)

References 47 publications

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Section: Resultsmentioning

confidence: 99%

“…Yang et al [ 69 ] discovered that the main components of the lipid-soluble subfraction of the H. fusiformis functional oil (HFFO) were tetradecanoic acid (11%), palmitic acid (37.80%), 9-hexadecenoic acid (2.67%), phytol (33.21%), and arachidonic acid (15.32%) ( Figure 6 ). These components have anti-neuroinflammatory properties that can help prevent Alzheimer’s disease [ 69 ]. Generally, oil extracts from terrestrial plants have been shown to possess several biological properties, including anti-inflammatory, neuroprotective, and antioxidant properties, as well as the ability to increase the bioavailability of other drugs [ 76 ].…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, a sterol (24-(S)-saringosterol) extracted from H. fusiformis enhanced cognition and alleviated disease by selectively activating liver X receptor β when Alzheimer’s disease mice were fed with H. fusiformis or its extract [ 125 ]. Furthermore, the H. fusiformis functional oil (HFFO) inhibited acetylcholinesterase (AChE), NO production, and reduced the ROS levels in BV-2 cells (mouse microglia) [ 69 ].…”

Section: Resultsmentioning

confidence: 99%

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Hizikia fusiformis: Pharmacological and Nutritional Properties

Meinita

Harwanto

Sohn

et al. 2021

Foods

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The brown seaweed Hizikia fusiformis (syn. Sargassum fusiforme), commonly known as “Hijiki”, has been utilized in traditional cuisine and medicine in East Asian countries for several centuries. H. fusiformis has attracted much attention owing to its rich nutritional and pharmacological properties. However, there has been no comprehensive review of the nutritional and pharmacological properties of H. fusiformis. The aim of this systematic review was to provide detailed information from the published literature on the nutritional and pharmacological properties of H. fusiformis. A comprehensive online search of the literature was conducted by accessing databases, such as PubMed, SpringerLink, ScienceDirect, and Google Scholar, for published studies on the nutritional and pharmacological properties of H. fusiformis between 2010 and 2021. A total of 916 articles were screened from all the databases using the preferred reporting items for systematic reviews and meta-analyses method. Screening based on the setdown criteria resulted in 59 articles, which were used for this review. In this review, we found that there has been an increase in the number of publications on the pharmacological and nutritional properties of H. fusiformis over the last 10 years. In the last 10 years, studies have focused on the proximate, mineral, polysaccharide, and bioactive compound composition, and pharmacological properties, such as antioxidant, anticancer, antitumor, anti-inflammatory, photoprotective, neuroprotective, antidiabetic, immunomodulatory, osteoprotective, and gastroprotective properties of H. fusiformis extracts. Overall, further studies and strategies are required to develop H. fusiformis as a promising resource for the nutrition and pharmacological industries.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Hizikia fusiformis: Pharmacological and Nutritional Properties

Meinita

Harwanto

Sohn

et al. 2021

Foods

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“…On the other hand, 111 combined to a site with the α-helical motif quite far from the active pocket. However, its docked pose showed even lower CDOCKER interaction energy (−50.36 kcal/mol) when compared to 110 , thus explaining its stronger anti-AChE activity [ 68 ].…”

Section: Marine-derived Compounds That Inhibit Acetylcholinesterase (Ache) and Butyrylcholinesterase (Buche) Activitiesmentioning

confidence: 99%

Marine-Derived Compounds with Anti-Alzheimer’s Disease Activities

Ghoran

Kijjoa

2021

Marine Drugs

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Alzheimer’s disease (AD) is an irreversible and progressive brain disorder that slowly destroys memory and thinking skills, and, eventually, the ability to perform simple tasks. As the aging population continues to increase exponentially, AD has become a big concern for society. Therefore, neuroprotective compounds are in the spotlight, as a means to tackle this problem. On the other hand, since it is believed—in many cultures—that marine organisms in an individual diet cannot only improve brain functioning, but also slow down its dysfunction, many researchers have focused on identifying neuroprotective compounds from marine resources. The fact that the marine environment is a rich source of structurally unique and biologically and pharmacologically active compounds, with unprecedented mechanisms of action, marine macroorganisms, such as tunicates, corals, sponges, algae, as well as microorganisms, such as marine-derived bacteria, actinomycetes, and fungi, have been the target sources of these compounds. Therefore, this literature review summarizes and categorizes various classes of marine-derived compounds that are able to inhibit key enzymes involved in AD, including acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), β-secretase (BACE-1), and different kinases, together with the related pathways involved in the pathogenesis of AD. The compounds discussed herein are emerging as promising anti-AD activities for further in-depth in vitro and in vivo investigations, to gain more insight of their mechanisms of action and for the development of potential anti-AD drug leads.

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“…But the study is rare on the brainhealth value of its oil. Previously, we reported that the Hizikia fusiforme functional oil (HFFO) contained arachidonic acid (ARA, one of the two main PUFAs in the brain) (20.54%), 11,14,17-eicosatrienoic acid (ETrA) (19.53%), phytol (6.55%) (Bazinet and Layé, 2014), and other molecules displayed in vitro acetylcholinesterase inhibitory and nitroxide scavenging activity (Yang et al, 2020). However, the in vivo effect remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Hizikia fusiforme functional oil (HFFO) prevents neuroinflammation and memory deficits evoked by lipopolysaccharide/aluminum trichloride in zebrafish

Nie

Zhou

et al. 2022

Front. Aging Neurosci.

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BackgroundOxidative stress, cholinergic deficiency, and neuroinflammation are hallmarks of most neurodegenerative disorders (NDs). Lipids play an important role in brain development and proper functioning. Marine-derived lipids have shown good memory-improving potentials, especially those from fish and microalgae. The cultivated macroalga Hizikia fusiforme is healthy food and shows benefits to memory, but the study is rare on the brain healthy value of its oil. Previously, we had reported that the Hizikia fusiforme functional oil (HFFO) contains arachidonic acid, 11,14,17-eicosatrienoic acid, phytol, and other molecules displaying in vitro acetylcholinesterase inhibitory and nitroxide scavenging activity; however, the in vivo effect remains unclear. In this study, we further investigated its potential effects against lipopolysaccharides (LPS)- or aluminum trichloride (AlCl3)-induced memory deficiency in zebrafish and its drug-related properties in silica.MethodsWe established memory deficit models in zebrafish by intraperitoneal (i.p.) injection of lipopolysaccharides (LPS) (75 ng) or aluminum trichloride (AlCl3) (21 μg), and assessed their behaviors in the T-maze test. The interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), acetylcholine (ACh), and malondialdehyde (MDA) levels were measured 24 h after the LPS/AlCl3 injection as markers of inflammation, cholinergic activity, and oxidative stress. Furthermore, the interaction of two main components, 11,14,17-eicosatrienoic acid and phytol, was investigated by molecular docking, with the important anti-inflammatory targets nuclear factor kappa B (NF-κB) and cyclooxygenase 2 (COX-2). Specifically, the absorption, distribution, metabolism, excretion, and toxicity (ADMET) and drug-likeness properties of HFFO were studied by ADMETlab.ResultsThe results showed that HFFO reduced cognitive deficits in zebrafish T-maze induced by LPS/AlCl3. While the LPS/AlCl3 treatment increased MDA content, lowered ACh levels in the zebrafish brain, and elevated levels of central and peripheral proinflammatory cytokines, these effects were reversed by 100 mg/kg HFFO except for MDA. Moreover, 11,14,17-eicosatrienoic acid and phytol showed a good affinity with NF-κB, COX-2, and HFFO exhibited acceptable drug-likeness and ADMET profiles in general.ConclusionCollectively, this study's findings suggest HFFO as a potent neuroprotectant, potentially valuable for the prevention of memory impairment caused by cholinergic deficiency and neuroinflammation.

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Chemical Composition and Anti‐Alzheimer's Disease‐Related Activities of a Functional Oil from the Edible Seaweed Hizikia fusiforme

Cited by 13 publications

References 47 publications

Hizikia fusiformis: Pharmacological and Nutritional Properties

Hizikia fusiformis: Pharmacological and Nutritional Properties

Marine-Derived Compounds with Anti-Alzheimer’s Disease Activities

Hizikia fusiforme functional oil (HFFO) prevents neuroinflammation and memory deficits evoked by lipopolysaccharide/aluminum trichloride in zebrafish

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