Chemical composition analysis of <i>Schisandra chinensis fructus</i> and its three processed products using UHPLC-Q-Orbitrap/MS-based metabolomics approach

Liu, Xiaokang; Guo, Yunlong; Cai, Guangzhi; Gong, Jiyu; Liu, Shuying

doi:10.1080/14786419.2020.1858416

Cited by 6 publications

(4 citation statements)

References 6 publications

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“…The Q-Orbitrap, a high-resolution mass spectrometer, allows molecular weight and fragment information. UHPLC-Q-Orbitrap-MS/MS are used to identify the metabolites in herbal medicines [ 17 , 18 ]. The compounds in TCM were characterized by combining parent ions with fragment ions.…”

Section: Methodsmentioning

confidence: 99%

The Potential Antioxidant Activity and Characterization of Bioactive Compounds of Stahlianthus involucratus

Wang

et al. 2021

BioMed Research International

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Stahlianthus involucratus (S. involucratus) has anti-inflammatory, antinociceptive, and antipyretic activities; however, there are no literature reports on its antioxidant capacity. This study presents a comparative assessment of the polyphenols contents, flavonoids contents, and antioxidant activity of the aqueous and methanol extracts of S. involucratus (ASI and MSI). Moreover, the expression of oxidative stress-related genes in H2O2-induced H9c2 cells pretreated with the MSI was measured by RT-qPCR, and furthermore, MSI were characterized by UHPLC-Q-Orbitrap-MS/MS. The results indicated that the MSI had higher antioxidant contents and antioxidant capacity, and MSI could inhibit H2O2-induced oxidative stress in H9c2 cells by activating the Nrf2/HO-1 pathway. UHPLC-Q-Orbitrap-MS/MS characterized 15 phenolic compounds from the MSI. In conclusion, S. involucratus has the potential antioxidant capacity.

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Section: Methodsmentioning

confidence: 99%

The Potential Antioxidant Activity and Characterization of Bioactive Compounds of Stahlianthus involucratus

Wang

et al. 2021

BioMed Research International

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“…They can also be processed to make tea, syrup, jam, compote, and a strong sweet wine from the fermented juice. A tincture can also be prepared from crushed seeds, dried berries, or leaves [ 233 , 234 , 235 ].…”

Section: Specific Nootropic Herb Shrub and Tree Speciesmentioning

confidence: 99%

Nootropic Herbs, Shrubs, and Trees as Potential Cognitive Enhancers

Malík

Tlustos

2023

Plants

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Plant-based nootropics are a diverse group of natural drugs that can improve cognitive abilities through various physiological mechanisms, especially in cases where these functions are weakened or impaired. In many cases, the nootropics enhance erythrocyte plasticity and inhibit aggregation, which improves the blood’s rheological properties and increases its flow to the brain. Many of these formulations possess antioxidant activity that protects brain tissue from neurotoxicity and improves the brain’s oxygen supply. They can induce the synthesis of neuronal proteins, nucleic acids, and phospholipids for constructing and repairing neurohormonal membranes. These natural compounds can potentially be present in a great variety of herbs, shrubs, and even some trees and vines. The plant species reviewed here were selected based on the availability of verifiable experimental data and clinical trials investigating potential nootropic effects. Original research articles, relevant animal studies, meta-analyses, systematic reviews, and clinical trials were included in this review. Selected representatives of this heterogeneous group included Bacopa monnieri (L.) Wettst., Centella asiatica (L.) Urban, Eleutherococcus senticosus (Rupr. & Maxim.) Maxim., Ginkgo biloba L., Lepidium meyenii Walp., Panax ginseng C.A. Meyer, Paullinia cupana Kunth, Rhodiola rosea L., Schisandra chinensis (Turcz.) Baill., and Withania somnifera (L.) Dunal. The species are depicted and described, together with their active components and nootropic effects, and evidence of their efficacy is presented. The study provides brief descriptions of the representative species, their occurrence, history, and the chemical composition of the principle medicinal compounds, with uses, indications, experimental treatments, dosages, possible side effects, and contraindications. Most plant nootropics must be taken at optimal doses for extended periods before measurable improvement occurs, but they are generally very well tolerated. Their psychoactive properties are not produced by a single molecule but by a synergistic combination of several compounds. The available data suggest that including extracts from these plants in medicinal products to treat cognitive disorders can have substantial potential therapeutic benefits.

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“…They can also be stored frozen. In addition to syrups and juices, a strong sweet wine can be made from the juice of the berries [253,254]. Schisandra fruits are known to the people of the Far East primarily as a tonic and stimulant against fatigue and exhaustion [253].…”

Section: Schisandra (Schisandra Chinensis)mentioning

confidence: 99%

Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs

Malík

Tlustos

2022

Nutrients

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Nootropics, also known as “smart drugs” are a diverse group of medicinal substances whose action improves human thinking, learning, and memory, especially in cases where these functions are impaired. This review provides an up-to-date overview of the potential effectiveness and importance of nootropics. Based on their nature and their effects, this heterogeneous group of drugs has been divided into four subgroups: classical nootropic compounds, substances increasing brain metabolism, cholinergic, and plants and their extracts with nootropic effects. Each subgroup of nootropics contains several main representatives, and for each one, its uses, indications, experimental treatments, dosage, and possible side effects and contraindications are discussed. For the nootropic plant extracts, there is also a brief description of each plant representative, its occurrence, history, and chemical composition of the medicinal part. Lastly, specific recommendations regarding the use of nootropics by both ill and healthy individuals are summarized.

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Chemical composition analysis of Schisandra chinensis fructus and its three processed products using UHPLC-Q-Orbitrap/MS-based metabolomics approach

Cited by 6 publications

References 6 publications

The Potential Antioxidant Activity and Characterization of Bioactive Compounds of Stahlianthus involucratus

The Potential Antioxidant Activity and Characterization of Bioactive Compounds of Stahlianthus involucratus

Nootropic Herbs, Shrubs, and Trees as Potential Cognitive Enhancers

Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs

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