Chemical Composition Analysis, Cytotoxic, Antimicrobial and Antioxidant Activities of Physalis angulata L.: A Comparative Study of Leaves and Fruit

Pillai, Jayachithra Ramakrishna; Wali, Adil Farooq; Menezes, Godfred Antony; Rehman, Muneeb U.; Wani, Tanveer A.; Arafah, Azher; Zargar, Seema; Mir, Tahir Maqbool

doi:10.3390/molecules27051480

Cited by 27 publications

(26 citation statements)

References 52 publications

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“…Based on [25], extracts of plant compounds have MIC values ranging from 0.008 to 256 mg/ml, the research also revealed that ethanol extract had more potency than aqueous extract. Ciplukan ethanol extract has a MIC value of 10 mg/ml on E. coli and S. aureus bacteria as well as shown in the study of [4]. The 30 mins ultrasonic treatments are the best treatment to obtain antibacterial activity, the longer the sonication time, the temperature of the instrument also increases, which causes some heat-sensitive compounds to be damaged.…”

Section: Antibacterial Activitymentioning

confidence: 94%

“…The study by [6] on ciplukan fruit showed that the total phenol obtained from ethanol and water extracts was 0.51 mg GAE/g and 0.46 mg GAE/g, respectively. Another study reported related to the total phenolic and flavonoid content of ciplukan using three different solvents (petroleum ether, ethyl acetate, and ethanol), the ciplukan extract using ethanol solvent had the highest content for total phenol and total flavonoid with values of 106.54 mg GAE/ g and 370.64 ± 4.33 mg QE/g, respectively [4]. In addition, study by [17] showed an increase in UAE temperature (20°C-60°C) directly proportional to an increase in total phenols and total flavonoids.…”

Section: Antioxidant Propertiesmentioning

confidence: 98%

“…Study by [3] also found high lipid, carbohydrate, and protein content in ciplukan fruit compared to the roots, leaves, and buds of this plant. Bioactive compounds including phenols and flavonoids that are reported to have antibacterial and IOP Publishing doi:10.1088/1755-1315/1246/1/012041 2 antioxidant activity are also found in ciplukan fruit [4,5]. The high phenolic content in ciplukan fruit when using ethanol as the extraction solvent compared to water was found [4,6].…”

Section: Introductionmentioning

confidence: 99%

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Ultrasonic-assisted extraction increases the antioxidant and antibacterial capabilities of ciplukan (Physalis angulata) extract

Iwansyah,

Wardhani,

Darsih

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

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Ciplukan (Physalis angulata) fruit is known to contain various bioactive compounds that can inhibit the growth of pathogenic bacteria and have radical scavenging activity. The purpose of this study is to ascertain how the antioxidant and antibacterial properties of ciplukan extract are affected by ultrasonic-assisted extraction. This study used ciplukan extract that has undergone ultrasonic treatment (P0: 24-hour maceration, P1: 30 minutes, P2: 60 minutes, and P3: 120 minutes). The total phenolic, flavonoid, and antioxidant activity of the ciplukan extract was then assessed using DPPH (2,2′-diphenylpicryl hydrazyl), and the antibacterial activity was assessed using dilution techniques. The outcomes demonstrated that total phenolic contents, flavonoids, and antioxidant activity were significantly impacted by the ultrasonic-assisted extraction method (P<0.05). The highest total phenolic content, flavonoid content, and antioxidant activity (IC50) obtained from the two-hour ultrasonic treatment (P3) were 176.62 mg GAE/g, 121.33mg QE/g, and 50.80 μg/mL, respectively. Furthermore, the capability of ciplukan extract to inhibit the growth of gram-positive and gram-negative bacteria was assessed. The thirty-minute ultrasonic treatment (P1) has the highest antibacterial activity, the MIC values for P1 treatment were 500 μg/mL on Staphylococcus aureus FNCC 0047 and 125 μg/mL on Escherichia coli ATCC 8739 and Pseudomonas aeruginosa ATCC 9027. These results indicate the antioxidant and antibacterial capabilities of ciplukan extract obtained from the physical extraction process using ultrasonic.

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Section: Antibacterial Activitymentioning

confidence: 94%

Section: Antioxidant Propertiesmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Ultrasonic-assisted extraction increases the antioxidant and antibacterial capabilities of ciplukan (Physalis angulata) extract

Iwansyah,

Wardhani,

Darsih

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

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“…Furthermore, they reported that the fruit extract contained more flavonoid and phenol compounds than leaves. Hence, the bioactive compounds belonging to these phytochemicals effectively scavenge the H 2 O 2 [34]. Another species, Physalisperuviana, also reported possessing considerable H 2 O 2 scavenging activity.…”

Section: H 2 O 2 Scavenging Potentialmentioning

confidence: 96%

Structural Prediction of Bioactive Compound Elucidated Through 1 H and 13C NMR Based Metabolomics from Physalis Minima

Pradeepkumar¹,

Muthukrishnan²,

Manikandan³

et al. 2022

J Adv Mater Sci Eng

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This study was performed to extract, purify, and characterize the bioactive compound from the ethanol extract of Physalis minima fruit. Furthermore, the free radicals scavenging potential of that purified and characterized test compound was investigated through in-vitro antioxidant studies. The study's findings demonstrated that the ethanol extract of Physalis minima fruits is supposed to contain many critical phytochemical constituents. The predominant fraction acquired from the extract via column chromatography and TLC was characterized using 13C NMR and1 H NMR techniques. The analyses results revealed that the chemical structure and name of the bioactive compound are 2-(3,4-dihydroxyphenyl) - 3, 4,4a 5-dihydro-2H-chromene-3,5,7-triol.

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“…Recent phytochemical and pharmacological studies have confirmed that P. angulata is rich in vitamins, minerals, antioxidants, and many important pharmacologically active constituents, including antibacterial, anti-inflammatory, and anticancer ingredients [3][4][5][6]. In many countries, such as China, Indonesia, Peru, Mexico, and Brazil, P. angulata is often used to treat a variety of illnesses, including dermatitis, tracheitis, impaludism, rheumatism, hepatitis, and analogous conditions [7][8][9][10]. Recently, increasing attention has been paid to the phytochemical and pharmacological aspects of P. angulata, and a variety of bioactive steroids with antitumor activities, including physagulins (A−Q), physangulidines (A−C), withangulatins (A−I), physalins (B, D, F−H), and withaminimin, have been isolated from the species [4,5,11].…”

Section: Introductionmentioning

confidence: 99%

Development of Chloroplast Microsatellite Markers and Evaluation of Genetic Diversity and Population Structure of Cutleaf Groundcherry (Physalis angulata L.) in China

Feng

Jiao

Zhang

et al. 2023

Plants

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Cutleaf groundcherry (Physalis angulata L.), an annual plant containing a variety of active ingredients, has great medicinal value. However, studies on the genetic diversity and population structure of P. angulata are limited. In this study, we developed chloroplast microsatellite (cpSSR) markers and applied them to evaluate the genetic diversity and population structure of P. angulata. A total of 57 cpSSRs were identified from the chloroplast genome of P. angulata. Among all cpSSR loci, mononucleotide markers were the most abundant (68.24%), followed by tetranucleotide (12.28%), dinucleotide (10.53%), and trinucleotide (8.77%) markers. In total, 30 newly developed cpSSR markers with rich polymorphism and good stability were selected for further genetic diversity and population structure analyses. These cpSSRs amplified a total of 156 alleles, 132 (84.62%) of which were polymorphic. The percentage of polymorphic alleles and the average polymorphic information content (PIC) value of the cpSSRs were 81.29% and 0.830, respectively. Population genetic diversity analysis indicated that the average observed number of alleles (Na), number of effective alleles (He), Nei’s gene diversity (h), and Shannon information indices (I) of 16 P. angulata populations were 1.3161, 1.1754, 0.1023, and 0.1538, respectively. Moreover, unweighted group arithmetic mean, neighbor-joining, principal coordinate, and STRUCTURE analyses indicated that 203 P. angulata individuals from 16 populations were grouped into four clusters. A molecular variance analysis (AMOVA) illustrated the considerable genetic variation among populations, while the gene flow (Nm) value (0.2324) indicated a low level of gene flow among populations. Our study not only provided a batch of efficient genetic markers for research on P. angulata but also laid an important foundation for the protection and genetic breeding of P. angulata resources.

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Chemical Composition Analysis, Cytotoxic, Antimicrobial and Antioxidant Activities of Physalis angulata L.: A Comparative Study of Leaves and Fruit

Cited by 27 publications

References 52 publications

Ultrasonic-assisted extraction increases the antioxidant and antibacterial capabilities of ciplukan (Physalis angulata) extract

Ultrasonic-assisted extraction increases the antioxidant and antibacterial capabilities of ciplukan (Physalis angulata) extract

Structural Prediction of Bioactive Compound Elucidated Through 1 H and 13C NMR Based Metabolomics from Physalis Minima

Development of Chloroplast Microsatellite Markers and Evaluation of Genetic Diversity and Population Structure of Cutleaf Groundcherry (Physalis angulata L.) in China

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