Chemical components of Fraxinus species

Kostova, I.; Iossifova, Tanya

doi:10.1016/j.fitote.2006.08.002

Cited by 116 publications

(124 citation statements)

References 75 publications

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“…The results obtained in those studies are in full agreement with our findings. Additionally, the Fraxinus genus is described as a rich source of flavones and flavonols that are derivatives of quercetin and kaempferol (26). The above HPLC analysis confirmed the presence of a flavone, luteolin, and a flavonol, quercetin, in FAB and FAL extracts, respectively.…”

Section: Groupsmentioning

confidence: 53%

“…The most remarkable observation from this data is that leaf and bark extracts do not share common chemicals and that all of the compounds with the exception of luteolin in bark were previously detected in this species (25,26). Moreover, the occurrence of secoridoids such as oleuropein and phenylethanoids such as tyrosol is a characteristic feature of Fraxinus species (26).…”

Section: Hplc Analysismentioning

confidence: 75%

“…This means that protection by F. angustifolia extracts against paracetamol-induced hepatotoxicity might involve inhibition of oxidative formation and/or detoxification of the paracetamol reactive metabolite. The high antioxidant capacities of the extracts (26) are probably implicated in those mechanisms.…”

Section: Histological Analysismentioning

confidence: 98%

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Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis

et al. 2016

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Section: Groupsmentioning

confidence: 53%

Section: Hplc Analysismentioning

confidence: 75%

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Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis

et al. 2016

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“…The presence of some flavonoids and hydroxycoumarins has been described in bark and leaves of Fraxinus spp, but not in wood. [11,19] Among detected compounds, 48 were identified, or tentatively characterized, based on their retention times, UV/Vis spectra and MS fragmentation patterns, whereas nine peaks remained unidentified.…”

Section: Resultsmentioning

confidence: 99%

“…Identification as 2-methoxycinnamic acid, a compound already found in Fraxinus spp., [11] was ruled out with the commercial standard, so peak 18 was only tentatively identified as a cinnamic compound.…”

Section: Lc-dad/esi-ms/ms Of Ash Wood Phenolic Compoundsmentioning

confidence: 99%

LC‐DAD/ESI‐MS/MS study of phenolic compounds in ash (Fraxinus excelsior L. and F. americana L.) heartwood. Effect of toasting intensity at cooperage

Sanz¹,

Simón

Cadahía

et al. 2012

J. Mass. Spectrom.

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The phenolic composition of heartwood extracts from Fraxinus excelsior L. and F. americana L., both before and after toasting in cooperage, was studied using LC-DAD/ESI-MS/MS. Low-molecular weight (LMW) phenolic compounds, secoiridoids, phenylethanoid glycosides, dilignols and oligolignols compounds were detected, and 48 were identified, or tentatively characterized, on the basis of their retention time, UV/Vis and MS spectra, and MS fragmentation patterns. Some LMW phenolic compounds like protocatechuic acid and aldehyde, hydroxytyrosol and tyrosol, were unlike to those for oak wood, while ellagic and gallic acid were not found. The toasting of wood resulted in a progressive increase in lignin degradation products with regard to toasting intensity. The levels of some of these compounds in medium-toasted ash woods were much higher than those normally detected in toasted oak, highlighting vanillin levels, thus a more pronounced vanilla character can be expected when using toasted ash wood in the aging wines. Moreover, in seasoned wood, we found a great variety of phenolic compounds which had not been found in oak wood, especially oleuropein, ligstroside and olivil, along with verbascoside and isoverbascoside in F. excelsior, and oleoside in F. americana. Toasting mainly provoked their degradation, thus in medium-toasted wood, only four of them were detected. This resulted in a minor differentiation between toasted ash and oak woods. The absence of tannins in ash wood, which are very important in oak wood, is another peculiar characteristic that should be taken into account when considering its use in cooperage.

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Chemical characterization, multivariate analysis and comparison of biological activities of different parts of Fraxinus mandshurica

Guo,

Liu,

Guo

et al. 2024

Biomedical Chromatography

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Fraxinus mandshurica (Oleaceae) is used as a traditional medicinal plant for the treatment of red eyes, menstrual disorders, excessive leucorrhea, chronic bronchitis and psoriasis. To perform chemical characterization of the secondary metabolites of F. mandshurica roots, bark, stems and leaves, 32 samples were collected from eight provinces in this study. A total of 64 chemical components were detected from four different parts of F. mandshurica by ultra‐performance liquid chromatography–quadrupole time‐of‐flight mass spectrometry. Meanwhile, a total of nine secoiridoids were obtained by natural product chemical extraction, isolation and identification methods. Quantitative analysis by high‐performance liquid chromatography–diode array detection–mass spectrometry showed the highest total content of secoiridoids in the bark, which is also consistent with the traditional medicinal parts. The results of methodological validation showed that the correlation coefficient (R2) values were all >0.9993, indicating a good linear range of the standard curve, while the relative standard deviations of precision, reproducibility and stability were <3%, and the spiked recoveries ranged from 98.22 to 102.27%, indicating that the experimental method was reliable and stable. In addition, fingerprinting and a heatmap were established to demonstrate the content trends of F. mandshurica more visually from different origins. Multivariate analysis, including principal component analysis and partial least squares discriminant analysis, was performed to determine the chemical characteristics of different parts of F. mandshurica, and six characteristic secoiridoids that could be used to distinguish different origins were screened. Finally, the inhibition of tyrosinase, α‐glucosidase, acetylcholinesterase and pancreatic lipase activities by the nine characteristic compounds and extracts from different parts were investigated, and the results showed that they all exhibited different degrees of enzyme activity inhibition and thus have potential applications in whitening and blemish removal, hypoglycemia, anti‐Alzheimer's disease and anti‐obesity as a new source of natural enzyme activity inhibitors. This study establishes an identification and evaluation method applicable to phytochemistry of different origins, which is a guideline for quality control, origin evaluation and clinical application of traditional medicinal plants. This is also an unprecedented study on the identification of the chemical composition of different parts of F. mandshurica, characteristic compounds and the inhibition of enzyme activity of extracts from different parts.

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Chemical components of Fraxinus species

Cited by 116 publications

References 75 publications

Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis

Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis

LC‐DAD/ESI‐MS/MS study of phenolic compounds in ash (Fraxinus excelsior L. and F. americana L.) heartwood. Effect of toasting intensity at cooperage

Chemical characterization, multivariate analysis and comparison of biological activities of different parts of Fraxinus mandshurica

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