Chemical Colitis Induced by Low-dose Hydrogen Peroxide Enema in a Cocaine User

Galo, Jason; Zaydlin, Michelle; Celli-Cabada, Diego A

doi:10.7759/cureus.7017

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Irritable bowel syndrome with constipation was associated with the presence of methanogens and higher methane production [65]. Cocaine use may produce gastrointestinal disorders including colitis and constipation [55,66,67]. Taken together, the greater abundance of these taxa suggests a potential for pathogenicity and gastrointestinal disorder in PWH who use cocaine.…”

Section: Discussionmentioning

confidence: 99%

Multiomic analysis reveals microbiome-related relationships between cocaine use and metabolites

Martínez

Stebliankin

Hernandez

et al. 2022

Aids

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Objective: Over 19 million individuals globally have a cocaine use disorder, a significant public health crisis. Cocaine has also been associated with a pro-inflammatory state and recently with imbalances in the intestinal microbiota as compared to nonuse. The objective of this pilot study was to characterize the gut microbiota and plasma metabolites in people with HIV (PWH) who use cocaine compared with those who do not. Design: Cross-sectional study. Methods: A pilot study in PWH was conducted on 25 cocaine users and 25 cocaine nonusers from the Miami Adult Studies on HIV cohort. Stool samples and blood plasma were collected. Bacterial composition was characterized using 16S rRNA sequencing. Metabolomics in plasma were determined using gas and liquid chromatography/mass spectrometry. Results: The relative abundances of the Lachnopspira genus, Oscillospira genus, Bifidobacterium adolescentis species, and Euryarchaeota phylum were significantly higher in the cocaine- using PWH compared to cocaine-nonusing PWH. Cocaine-use was associated with higher levels of several metabolites: products of dopamine catabolism (3-methoxytyrosine and 3-methoxytyramine sulfate), phenylacetate, benzoate, butyrate, and butyrylglycine. Conclusions: Cocaine use was associated with higher abundances of taxa and metabolites known to be associated with pathogenic states that include gastrointestinal conditions. Understanding key intestinal bacterial functional pathways that are altered due to cocaine use in PWH will provide a better understanding of the relationships between the host intestinal microbiome and potentially provide novel treatments to improve health.

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Section: Discussionmentioning

confidence: 99%

Multiomic analysis reveals microbiome-related relationships between cocaine use and metabolites

Martínez

Stebliankin

Hernandez

et al. 2022

Aids

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Case Report: Toxic megacolon secondary to chronic constipation and cocaine consumption

Dimas,

Hernández,

Peralta

et al. 2024

Front. Surg.

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Toxic megacolon (TM) is a severe condition characterized by acute colonic dilation, with specific radiological and clinical signs. The multifactorial etiology of TM is primarily associated with inflammatory bowel disease and infections. However, TM remains a challenging complication due to its potential for rapid progression to life-threatening conditions. This report describes a rare case of TM in a 25-year-old male with a history of recurrent constipation and chronic cocaine consumption. Examination and imaging indicated acute intestinal obstruction with dilated colon segments and fecal impaction, necessitating an urgent laparotomy. Surgery revealed pan-colonic dilatation and sigmoid perforations, leading to a total colectomy and ileostomy. Chronic constipation, often perceived as benign, can escalate into a critical situation, possibly exacerbated by cocaine-induced muscle weakness and hypoxia. Evidence suggests that cocaine negatively affects the intestinal mucosa, potentially leading to ischemia. Chronic factors, including the use of enemas, may have contributed to megacolon development and perforation. Overall, this report underscores the critical elements of diagnosis and the importance of patients’ medical history, particularly those with unusual risk profiles. In addition, it highlights the need for further research to fully understand the implications of these cases.

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Chemical Colitis Induced by Low-dose Hydrogen Peroxide Enema in a Cocaine User

Cited by 2 publications

References 8 publications

Multiomic analysis reveals microbiome-related relationships between cocaine use and metabolites

Multiomic analysis reveals microbiome-related relationships between cocaine use and metabolites

Case Report: Toxic megacolon secondary to chronic constipation and cocaine consumption

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