Chemical characterization with in vitro biological activities of Gypsophila species

Zheleva‐Dimitrova, Dimitrina; Zengin, Gökhan; Balabanova, Vessela; Voynikov, Yulian; Lozanov, Valentin; Lazarova, Irına; Gevrenova, Reneta

doi:10.1016/j.jpba.2018.03.040

Cited by 28 publications

(39 citation statements)

References 47 publications

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“…TPC and TFC from various Gysophila species were previously reported (Zheleva‐Dimitrova et al, ). Accordingly, TPC of G. glomerata, G. trichotoma, and G. perfoliata were 20.59, 17.07, and 21.60 mg GAE/g extract, respectively, and TFC of the same species were 33.00, 35.58, and 25.07 mg RE/g extract, respectively.…”

Section: Results and Disscussionmentioning

confidence: 77%

“…Total flavonoid content was parallel to the phenolic content that is the methanol extracts were richer than water extracts except for G. arrosti. The highest flavonoid content was determined in water (114.21 mg QE/g extract) and methanol (89.77 mg QE/g extract) extracts of G. arrosti, while the lowest flavon content was in water (16.82 mg QE/g extract) and methanol (32.52 mg QE/g extract) extracts of G. tuberculosa.TPC and TFC from various Gysophila species were previously reported(Zheleva-Dimitrova et al, 2018). Accordingly, TPC of G.…”

mentioning

confidence: 76%

“…Gypsophila is the genus of mostly perennial plants that widely grows in Asia and Europe. Various Gypsophila taxa have been utilized for different purpose in folk medicine (Zheleva‐Dimitrova et al, ). For example, G. oldhamiana and G. paniculata have been widely used to lowering fever, treat consumptive disease, malnutrition syndrome, and diabetes (Chen, Luo, & Kong, ).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preliminary phytochemical analysis and evaluation of in vitro antioxidant, antiproliferative, antidiabetic, and anticholinergics effects of endemicGypsophilataxa from Turkey

et al. 2019

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The phenolic contents and antioxidant, anticancer, antidiabetic, and anticholinergic potentials of four endemic Gysophila taxa (G. pallida, G. arrosti, G. tuberculosa, and G. eriocalyx) were investigated. The HPLC analysis showed that methanol extracts of all the tested species were richer in phenolics than water extracts. 3,4‐dihydroxybenzoic acid, p‐hydroxybenzoic acid, vanillin, syringic acid, and p‐coumaric acid were detected in all extracts. In parallel to the phenolic contents, methanol extracts displayed comparatively higher antioxidant activity than water extracts. Additionally, all extracts exhibited dose‐dependent antiproliferative activity on the cancer cell lines with lower IC50 values changing from 0.170 to 1.805 mg/ml. Moreover, the extracts impressively inhibited the acetylcholinesterase (0.63–26.04), butyrylcholinesterase (3.66–10.73), and α‐glycosidase (98.52–235.55) enzymes with very low IC50 (mg/ml) values. Together, the present results indicate that Gysophila taxa have various biological activities together with higher phenolic contents. Hence, these species hold good potential for use in the pharmaceutical industry. Practical applications Gypsophila taxa having numerous biological activities have been used for different purpose in folk medicine as well as their use in the food industry. The obtained results of the current study indicated that the extracts of Gypsophila taxa are rich in phenolics and flavonoids with powerful antioxidant and antiproliferative activity against different type of cancer cell lines. In addition, the extracts obtained from these taxa showed notable antidiabetic and anticholinergics effects. Gypsophila taxa could be used as a natural material to develop anticancer, antidiabetic, and anticholinergic drugs.

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Section: Results and Disscussionmentioning

confidence: 77%

mentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preliminary phytochemical analysis and evaluation of in vitro antioxidant, antiproliferative, antidiabetic, and anticholinergics effects of endemicGypsophilataxa from Turkey

et al. 2019

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“…The flavonoid aglycone and glycoside group remains one of the most extensive groups of polyphenols in Caryophyllaceae. Most of these compounds occur in Silene L., Dianthus L. (Obmann et al 2011a, b;Boguslavskaya et al 1983), Gypsophila L. (Zhang et al 2011a, b;Zheleva-Dimitrova et al 2018), Stellaria L. (Mikšátková et al 2014), Spergularia Presl. (Ferreres et al 2011) and Herniaria L. (Elhagali et al 2019;El Mabruki et al 2014).…”

Section: Flavonoids Of the Caryophyllaceae And Their Main Biological Activitiesmentioning

confidence: 99%

Flavonoids of the Caryophyllaceae

Jakimiuk

2021

Phytochem Rev

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The plant family Caryophyllaceae, commonly known as the pink family, is divided into 3 subfamilies and contains over 80 genera with more than 2600 species that are widely distributed in temperate climate zones. Plants belonging to this family produce a variety of secondary metabolites important in an ecological context; however, some of these metabolites also show health-promoting activities. The most important classes of phytochemicals include saponins, phytoecdysteroids, other sterols, flavonoids, lignans, other polyphenols, essential oils, and N-containing compounds such as vitamins, alkaloids or cyclopeptides. Flavonoids are polyphenolic compounds that remain one of the most extensively studied constituents of the Caryophyllaceae family. Numerous structurally diverse aglycones, including flavones, flavonols, flavonones (dihydroflavones), flavonols, isoflavones, and their O- or C-glycosides, exhibit multiple interesting biological and pharmacological activities, such as antioxidant, anti-inflammatory, anti-oedemic, antimicrobial, and immunomodulatory effects. Thus, this review analysed the flavonoid composition of 26 different genera and more than 120 species of Caryophyllaceae for the first time.

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Development of phytotherapeutic nanoformulation containing Gypsophila eriocalyx and its evaluation as a candidate formulation for osteoporosis treatment on human bone marrow stem cells

Kaymak,

Kurtur,

Gok

et al. 2024

Phytochemical Analysis

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IntroductionOsteoporosis, one of the common bone diseases, manifests itself as a decrease in bone mass. Recently, the use of medicinal plants in the search for effective and low‐toxicity therapeutics for the prevention or treatment of osteoporosis has become a trending topic.ObjectiveIn this study, we aim to prepare a controlled drug carrier system loaded with Gypsophila eriocalyx to determine its potential for anti‐osteoporosis applications.MethodsGypsophila eriocalyx extract (GEE) was prepared, and components were determined. The molecular interactions of the components with Cathepsin K (CatK), which is used as a target in drug development against osteoporosis, were revealed by in silico molecular docking and MD methods. ADMET profiles were also examined. GEE‐loaded chitosan nanoparticles (CNPs) were synthesized. The nanoparticles' morphology, encapsulation efficiency, loading capacity, release profile, average size, polydispersity index, and zeta potentials were determined. The cytotoxic effects of GEE and GEE‐loaded CNPs on the L929 and osteogenic proliferation profiles on human bone marrow stem cells (hBMC) were examined.ResultsThe MD analysis revealed no breaks or atomic changes in the dynamic system, and the docking analysis confirmed the continued interaction of identical residues. It was determined that the GEE‐loaded CNP formulation was produced successfully, had no toxic effect on the L929, and had an osteogenic proliferation effect on hBMC.ConclusionIn line with the in vitro and in silico results obtained, it was evaluated that GEE‐loaded CNPs can be used as a controlled drug release system as a candidate formulation with phytotherapeutic properties for osteoporosis treatment.q1

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Chemical characterization with in vitro biological activities of Gypsophila species

Cited by 28 publications

References 47 publications

Preliminary phytochemical analysis and evaluation of in vitro antioxidant, antiproliferative, antidiabetic, and anticholinergics effects of endemicGypsophilataxa from Turkey

Preliminary phytochemical analysis and evaluation of in vitro antioxidant, antiproliferative, antidiabetic, and anticholinergics effects of endemicGypsophilataxa from Turkey

Flavonoids of the Caryophyllaceae

Development of phytotherapeutic nanoformulation containing Gypsophila eriocalyx and its evaluation as a candidate formulation for osteoporosis treatment on human bone marrow stem cells

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