Chemical characterization of tobacco-free “modern” oral nicotine pouches and their position on the toxicant and risk continuums

Azzopardi, David; Liu, Chuan; Murphy, James J.

doi:10.1080/01480545.2021.1925691

Cited by 70 publications

(93 citation statements)

References 34 publications

(33 reference statements)

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“…Nicotine pouches may appeal to young adults who use tobacco and might be interested in alternative nicotine products that lack pulmonary exposure, but also may appeal to young adult non-users of nicotine/tobacco products. Some evidence indicates that nicotine pouches have a toxicity level lower than combustible tobacco, approaching levels comparable to nicotine replacement therapy products [ 7 ]. The relative health effects of using nicotine pouches compared to e-cigarettes and other non-combustible tobacco products (e.g., heated tobacco products, snus) are unknown [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Some evidence indicates that nicotine pouches have a toxicity level lower than combustible tobacco, approaching levels comparable to nicotine replacement therapy products [ 7 ]. The relative health effects of using nicotine pouches compared to e-cigarettes and other non-combustible tobacco products (e.g., heated tobacco products, snus) are unknown [ 7 ]. However, nicotine pouches lack exposure to toxins present in some e-cigarettes, such as metals [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…The relative health effects of using nicotine pouches compared to e-cigarettes and other non-combustible tobacco products (e.g., heated tobacco products, snus) are unknown [ 7 ]. However, nicotine pouches lack exposure to toxins present in some e-cigarettes, such as metals [ 7 ]. Hence, if nicotine pouches appeal to young adult users of nicotine/tobacco products and help users transition away from other nicotine/tobacco products, nicotine pouches might benefit this segment of the young adult population.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Differences in Young Adults’ Perceptions of and Willingness to Use Nicotine Pouches by Tobacco Use Status

Vogel

Barrington‐Trimis

Kechter

et al. 2022

IJERPH

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Oral nicotine pouches may appeal to young adult current nicotine/tobacco users interested in alternative forms of nicotine that lack pulmonary exposure, but may also appeal to young adult non-users of nicotine/tobacco products. We used data from a 2020 remote digital survey of an ongoing cohort study of young adults from Southern California (aged 19–23) to examine differences in pouch perceptions and use willingness across nicotine/tobacco use statuses. Participants who had never used nicotine pouches (N = 1167) viewed text/imagery from mass-marketed pouch packaging and advertising, then completed measures of willingness to use nicotine pouches, pouch harm perceptions, and hypothetical choice of cigarettes or e-cigarettes over pouches. Willingness to use pouches was significantly higher among non-combustible only (33.8%), combustible only (29.3%), and dual (43.9%) users than non-users (14.7%). Overall, 49.1% of participants were uncertain whether pouches were less harmful than cigarettes and 52.4% were uncertain whether pouches were less harmful than e-cigarettes. Relative harm perceptions did not significantly differ by tobacco use status. Those using non-combustible products (either alone or as part of dual use with combustible tobacco) had greater odds than non-users of reporting that they would use e-cigarettes over nicotine pouches. By contrast, all tobacco product user groups reported greater odds than non-users that they would use cigarettes over pouches. In sum, a sizable minority of young adults might be willing to try using nicotine pouches, but most are uncertain about the relative harm of pouches.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Differences in Young Adults’ Perceptions of and Willingness to Use Nicotine Pouches by Tobacco Use Status

Vogel

Barrington‐Trimis

Kechter

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…Unlike snus, however, NPs typically do not contain tobacco but pharmaceutical grade nicotine absorbed onto a cellulose matrix in a porous pouch [ 19 – 21 ]. The comparatively simple composition of NPs relative to snus is reflected in a recent toxicant analysis, which showed that NPs contain lower levels than snus of 10 harmful and potentially harmful tobacco constituents (HPHCs) and undetectable levels of a further 13 HPHCs [ 20 ]. In vitro studies also indicate that extracts from NPs are significantly less biologically active than extracts from Swedish snus or cigarette smoke [ 22 ], supporting a potential role of NPs in tobacco harm reduction.…”

Section: Introductionmentioning

confidence: 99%

A Randomised Study to Investigate the Nicotine Pharmacokinetics of Oral Nicotine Pouches and a Combustible Cigarette

McEwan

Azzopardi

Gale

et al. 2021

Eur J Drug Metab Pharmacokinet

Self Cite

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Background and Objectives Nicotine pouches (NPs) are a relatively new type of oral smokeless tobacco-free nicotine product. Currently, few data are available on the nicotine pharmacokinetics or subjective effects of NP use. The objective of this study was to determine and compare the pharmacokinetics of nicotine absorption into the blood from different NP variants and a combustible cigarette. Methods In a randomised, controlled, crossover clinical study, nicotine pharmacokinetics and subjective effects were compared among commercially available NPs (five different brands; 6-10 mg nicotine/pouch) and a combustible cigarette. During an 8-day confinement period, 35 healthy adult participants who were current dual users of snus and combustible cigarettes used one study product each day for a defined period following overnight nicotine abstinence. Results Nicotine maximum plasma concentration (C max ) and area under the plasma concentration-time curve between 0 and 6 h (AUC 0-6h ) were significantly greater for the Lyft 10 mg NP than for the cigarette (both p < 0.0001), while the other NPs had C max and AUC 0-6h values that were either greater than or similar to those of the cigarette. Plasma nicotine concentration was not associated with the nicotine contents of the NPs. Time to reach maximum plasma concentration (T max ) was higher for all NPs (60-65 min) than for the cigarette (7 min). Regarding subjective effects, liking and intent to use product again scores were higher for the cigarette than for any NP and were lowest for the NP with the lowest nicotine content. Conclusions This study provides important insight into nicotine pharmacokinetics and subjective effects during NP use, and demonstrates that NPs can provide nicotine in amounts sufficient to replicate cigarette smokers' nicotine uptake following a switch from conventional cigarettes to these potentially less harmful NP products. Further studies are required to ascertain how physical characteristics of NPs other than nicotine content may affect nicotine delivery, pharmacokinetics and subjective responses. ISRCTN Clinical Trial Registry ISRCTN17828518.

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“…Studie uvádějí nižší hladiny toxinů v MOP ve srovnání se švédským snusem (23). Cytotoxicita nikotinového sáčku a švédského snusu je výrazně nižší než u cigarety, v případě nikotinového sáčku dokonce minimální (24).…”

Section: Rizikaunclassified

Nicotine pouches - a medicine from tobacco shops?

Zvolská¹

2021

Hygiena

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KRÁTKÁ SDĚLENÍSOUHRN S rostoucím vědomím devastujících vlivů kouření, obtěžujícím zápachem a dráždivostí kouře se objevují nové výrobky, které mohou nikotin bez spalování dodat především těm, kdo nikotin nedokázali nebo nechtěli přestat užívat. Nejsou ovšem určeny nekuřákům včetně dětí. Novinkou z poslední doby jsou nikotinové sáčky, které neobsahují žádný tabák -jejich zdravotní riziko je minimální. Tento článek podává přehled současných znalostí.

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Chemical characterization of tobacco-free “modern” oral nicotine pouches and their position on the toxicant and risk continuums

Abstract: 2021): Chemical characterization of tobacco-free "modern" oral nicotine pouches and their position on the toxicant and risk continuums, Drug and Chemical Toxicology,

Cited by 70 publications

References 34 publications

Differences in Young Adults’ Perceptions of and Willingness to Use Nicotine Pouches by Tobacco Use Status

Differences in Young Adults’ Perceptions of and Willingness to Use Nicotine Pouches by Tobacco Use Status

A Randomised Study to Investigate the Nicotine Pharmacokinetics of Oral Nicotine Pouches and a Combustible Cigarette

Nicotine pouches - a medicine from tobacco shops?

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