Chemical characterization of procyanidins from Spatholobus suberectus and their antioxidative and anticancer activities

Li, Wenting; Liu, Jing; Guan, Ronggui; Chen, Jianping; Yang, Dan; Zhao, Zhimin; Wang, Dongmei

doi:10.1016/j.jff.2014.11.009

Cited by 36 publications

(39 citation statements)

References 32 publications

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“…The antioxidant and potential beneficial effects of different sources of proanthocyanidins against human LDL-cholesterol oxidation and proliferation of breast cancer cells has already been reported [12,25,32]. Contamination with mycotoxins remains a concern for different food products such as milk, wheat and peanuts [33][34][35].…”

Section: Identification and Quantification Of Phenolic Compoundsmentioning

confidence: 99%

Phenolic Profile of Peanut By‐products: Antioxidant Potential and Inhibition of Alpha‐Glucosidase and Lipase Activities

Camargo

Regitano-D’Arce

Shahidi

2017

J Americ Oil Chem Soc

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Free, esterified, etherified and insolublebound phenolics from three samples, namely meal from whole peanuts (MWP), meal from dry-blanched peanuts (MDBP) and peanut skin (PS) were evaluated for their total phenolic content (TPC), and phenolic profile using HPLC-DAD-ESI-MS n . The TPC was in the order of PS > MWP > MDBP. Among 37 compounds identified 10 were reported for peanuts for the first time. Proanthocyanidins were detected in peanut skin and MWP, but not in MDBP. The presence of peanut skin in MWP rendered up to 9.8-fold higher scavenging activity towards the DPPH radical as compared with MDBP. Phenolics from all samples and fractions showed inhibition of alpha-glucosidase and lipase activities, which are key enzymes involved in the absorption of glucose and triacylglycerols, respectively. Therefore, their antioxidant properties as well as their potential role in the management of diabetes and obesity makes them worthy of further consideration as functional food ingredients.Electronic supplementary material The online version of this article (

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Section: Identification and Quantification Of Phenolic Compoundsmentioning

confidence: 99%

Phenolic Profile of Peanut By‐products: Antioxidant Potential and Inhibition of Alpha‐Glucosidase and Lipase Activities

Camargo

Regitano-D’Arce

Shahidi

2017

J Americ Oil Chem Soc

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“…As natural antioxidants, proanthocyanidins are used to stabilize food colors and to prevent rancidity due to oxidation of unsaturated fats (Malien-Aubert et al 2002; Li and Deinzer 2009; Hellenbrand et al 2015) as well as for chemoprevention of a variety of degenerative diseases (Shi et al 2003; Faria et al 2006; Han et al 2007). In addition to antioxidant properties, procyanidins have been reported to exhibit anticancer (Gossé et al 2005; Martin et al 2013; Li et al 2015), anti-infectious (Chaves and Gianfagna 2007), anti-inflammatory (Gentile et al 2012; Tatsuno et al 2012; Vázquez-Agell et al 2013), cardioprotective (de Pascual-Teresa et al 2010; Arranz et al 2013), antimicrobial (Benavente-García et al 1997), antiviral (Kimmel et al 2011), antimutagenic (Duan et al 2010), wounding healing (Zhang et al 2016), antihyperglycemic (Montagut et al 2010) as well as anti-allergic (Akiyama et al 2000) activities.…”

Section: Introductionmentioning

confidence: 99%

Procyanidins: a comprehensive review encompassing structure elucidation via mass spectrometry

2017

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Procyanidins are polyphenols abundant in dietary fruits, vegetables, nuts, legumes, and grains with a variety of chemopreventive biological effects. Rapid structure determination of these compounds is needed, notably for the more complex polymeric procyanidins. We review the recent developments in the structure elucidation of procyanidins with a focus on mass spectrometric approaches, especially liquid chromatography-tandem mass spectrometry (LC-MS/MS) and matrix-assisted laser desorption ionization (MALDI) MS/MS.

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“…Antioxidants can protect cells from oxidative damage though neutralizing ROS. In recent years, many studies have demonstrated that the intake of plant products that are rich in antioxidant phytochemicals can reduce the incidence of many diseases including cancer [9,10]. Therefore, it is important to seek natural antioxidants with anticancer potentials.…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Assessment of Bioactive Metabolites, Antioxidant and Antiproliferative Activities of Cyclocarya paliurus (Batal.) Iljinskaja Leaves

Zhou

Chen

Lin

et al. 2019

Forests

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Cyclocarya paliurus (Batal.) Iljinskaja is an indigenous and multifunction tree species in China, but it is mainly used in pharmaceutical and nutraceutical ingredients. To make a comprehensive evaluation on its bioactive metabolites, antioxidant and antitumor potentials of C. paliurus leaves, the leaf samples were collected from 15 geographic locations (natural populations) throughout its distribution areas. High-performance liquid chromatography (HPLC) and colorimetric methods were used to detect the contents of bioactive metabolites. The antioxidant activity was evaluated by 2,2′-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and reducing power assays. The antiproliferative activity on different cancer cell types was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Contents of bioactive metabolites, and antioxidant and antiproliferative activities in the extracts were significantly affected by solvent and population. In most cases, the contents of flavonoids and triterpenoids, and the antioxidant and antiproliferative activities in the ethanol extracts were higher than the water extracts. The best scavenging capacity of DPPH (IC50 = 0.34 mg/mL) and ABTS (IC50 = 0.50 mg/mL) radical occurred in the ethanol extracts of S15 and S7 population respectively, while the strongest reducing power (EC50 = 0.71 mg/mL) was achieved in the ethanol extracts of S14 population. The antiproliferation effects of C. paliurus extracts on cancer cells varied with different cell types. The HeLa cell was the most sensitive to C. paliurus extracts, and their IC50 values of the ethanol extracts varied from 0.13 to 0.42 mg/mL among C. paliurus populations. Redundancy analysis showed that total polyphenol had the greatest contribution to the antioxidant activity, but total flavonoid was mostly responsible for the antiproliferation effects. These results would provide important scientific evidences not only for developing C. paliurus as a potent antioxidant and antitumor reagent, but also for obtaining the higher yield of bioactive compounds in the C. paliurus plantation.

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Chemical characterization of procyanidins from Spatholobus suberectus and their antioxidative and anticancer activities

Cited by 36 publications

References 32 publications

Phenolic Profile of Peanut By‐products: Antioxidant Potential and Inhibition of Alpha‐Glucosidase and Lipase Activities

Phenolic Profile of Peanut By‐products: Antioxidant Potential and Inhibition of Alpha‐Glucosidase and Lipase Activities

Procyanidins: a comprehensive review encompassing structure elucidation via mass spectrometry

A Comprehensive Assessment of Bioactive Metabolites, Antioxidant and Antiproliferative Activities of Cyclocarya paliurus (Batal.) Iljinskaja Leaves

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