Chemical characterization of Glaucosciadum cordifolium extracts obtained by different extraction techniques and their biopharmaceutical effects

Cvetanović Kljakić, Aleksandra; Božunović, Jelena; Gašić, Uroš; Seebaluck-Sandoram, Roumita; Uba, Abdullahi Ibrahim; Mahomoodally, Mohamad Fawzi; Yildiztugay, Evren; Zengin, Gokhan

doi:10.1016/j.procbio.2023.10.007

Process Biochemistry

2023

DOI: 10.1016/j.procbio.2023.10.007

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Chemical characterization of Glaucosciadum cordifolium extracts obtained by different extraction techniques and their biopharmaceutical effects

Aleksandra Cvetanović Kljakić,

Jelena Božunović,

Uroš Gašić

et al.

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2024

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UHPLC‐MS/MS analysis, cytotoxic, enzyme inhibition, and antioxidant properties of Lantana camara L. extracts obtained by conventional and nonconventional methods

Cvetanović Kljakić,

Lončar,

Sinan

et al. 2024

Archiv der Pharmazie

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Lantana camara is widely known as a garden plant, but its use for various medicinal purposes is widespread in traditional medicine. In the frame of this study, L. camara was subjected to several different extraction techniques, including supercritical carbon dioxide extraction, accelerated solvent extraction (ASE), homogenizer‐assisted extraction, microwave‐assisted extraction, ultrasound‐assisted extraction, maceration, and Soxhlet extraction. The investigation encompasses the analysis of the chemical composition alongside assessments of biological activities, such as antioxidant and enzyme‐inhibition potential and cytotoxicity of the obtained extracts. The obtained results showed that the extract obtained by accelerated‐solvent extraction was the richest in the content of total phenols and of individual compounds. Of the 17 components identified in total, hispidulin was detected in the highest concentration (5.43–475.97 mg/kg). In the antioxidant assays, the extracts obtained by accelerated‐solvent and microwave extraction possessed the highest level of antioxidant and antiradical protection. All obtained extracts showed enzyme‐inhibitory action on amylase, glucosidase, tyrosinase, and cholinesterase, showing a high potential for application against diseases induced by excessive activity of these enzymes. Cytotoxic analysis was performed on normal and tumor cells, whereby the obtained IC50 values were in the range of 7.685–79.26 µg/mL, showing the high cytotoxicity of the obtained extracts. Using Z score analysis, ASE resulted in an optimal combination of tested quality characteristics of the L. camara extracts.

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UHPLC‐MS/MS analysis, cytotoxic, enzyme inhibition, and antioxidant properties of Lantana camara L. extracts obtained by conventional and nonconventional methods

Cvetanović Kljakić,

Lončar,

Sinan

et al. 2024

Archiv der Pharmazie

View full text Add to dashboard Cite

show abstract

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Chemical characterization of Glaucosciadum cordifolium extracts obtained by different extraction techniques and their biopharmaceutical effects

Cited by 1 publication

References 31 publications

UHPLC‐MS/MS analysis, cytotoxic, enzyme inhibition, and antioxidant properties of Lantana camara L. extracts obtained by conventional and nonconventional methods

UHPLC‐MS/MS analysis, cytotoxic, enzyme inhibition, and antioxidant properties of Lantana camara L. extracts obtained by conventional and nonconventional methods

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