Chemical characterization of Citrus limon var. pompia and incorporation in phospholipid vesicles for skin delivery

Manconi, Maria; Manca, Maria Letizia; Marongiu, Francesca; Caddeo, Carla; Castangia, Inés; Petretto, Giacomo Luigi; Pintore, Giorgio Antonio Mario; Sarais, Giorgia; Droogmans, Guy; Zaru, Marco; Bacchetta, Gianluigi; Fadda, Anna Maria

doi:10.1016/j.ijpharm.2016.04.014

Cited by 34 publications

(49 citation statements)

References 34 publications

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“…Scientific studies have shown a significant antioxidant effect of C. limon fruit extracts, which is the reason they are recommended for use in anti-ageing cosmetics [8,48]. The use of different carriers for C. limon extracts (e.g., hyalurosomes, glycerosomes) in cosmetics production technology contributes to an even greater inhibition of oxidative stress in skin-building structures, including keratinocytes and fibroblasts (Table 9) [79]. In addition, vitamin C from C. limon is used as an ingredient in specialized dermocosmetics.…”

Section: Cosmetological Applicationsmentioning

confidence: 99%

Citrus limon (Lemon) Phenomenon—A Review of the Chemistry, Pharmacological Properties, Applications in the Modern Pharmaceutical, Food, and Cosmetics Industries, and Biotechnological Studies

Klimek-Szczykutowicz

Szopa

2020

Plants

270

153

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This review presents important botanical, chemical and pharmacological characteristics of Citrus limon (lemon)—a species with valuable pharmaceutical, cosmetic and culinary (healthy food) properties. A short description of the genus Citrus is followed by information on the chemical composition, metabolomic studies and biological activities of the main raw materials obtained from C. limon (fruit extract, juice, essential oil). The valuable biological activity of C. limon is determined by its high content of phenolic compounds, mainly flavonoids (e.g., diosmin, hesperidin, limocitrin) and phenolic acids (e.g., ferulic, synapic, p-hydroxybenzoic acids). The essential oil is rich in bioactive monoterpenoids such as D-limonene, β-pinene, γ-terpinene. Recently scientifically proven therapeutic activities of C. limon include anti-inflammatory, antimicrobial, anticancer and antiparasitic activities. The review pays particular attention, with references to published scientific research, to the use of C. limon in the food industry and cosmetology. It also addresses the safety of use and potential phototoxicity of the raw materials. Lastly, the review emphasizes the significance of biotechnological studies on C. limon.

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Section: Cosmetological Applicationsmentioning

confidence: 99%

Citrus limon (Lemon) Phenomenon—A Review of the Chemistry, Pharmacological Properties, Applications in the Modern Pharmaceutical, Food, and Cosmetics Industries, and Biotechnological Studies

Klimek-Szczykutowicz

Szopa

2020

Plants

270

153

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“…The vesicle dispersions (2 mL) were purified from the non-incorporated active components by dialysis against water (4 L) at 25 • C for 3 h (with water refreshed every 30 min.) by using Spectra/Por ® membranes (12-14 kDa MW cut-off, 3 nm pore size; Spectrum Laboratories Inc., DG Breda, the Netherlands) [2,18]. The non-dialysed and dialysed vesicles were diluted with methanol and the amounts of citral or the main components of the pompia essential oil were quantified by gas chromatography, as reported in Section 2.3, to determine entrapment efficiency (EE), which was calculated as the percentage of the active components recovered in the dialysed samples versus the amounts that were found in non-dialysed samples.…”

Section: Vesicle Preparationmentioning

confidence: 99%

“…Citrus limon (L.) Osbeck var. pompia Camarda, which is also known as Citrus monstruosa, of the Rutaceae family [1], is an ancient endemic cultivar only grown in some warm areas of the north-eastern Sardinia (Italy) [2,3]. It is probably a hybrid species derived from citron and lemon that produces irregularly shaped, yellow fruits that are characterized by a low juice content and a reduced level of sugar [4].…”

Section: Introductionmentioning

confidence: 99%

Comparison between Citral and Pompia Essential Oil Loaded in Phospholipid Vesicles for the Treatment of Skin and Mucosal Infections

et al. 2020

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Citrus species extracts are well known sources of bio-functional compounds with health-promoting effects. In particular, essential oils are known for their antibacterial activity due to the high content of terpenes. In this work, the steam-distilled essential oil from the leaves of Citrus limon var. pompia was loaded in phospholipid vesicles. The physico-chemical characteristics of the essential oil loaded vesicles were compared with those of vesicles that were loaded with citral, which is one of the most abundant terpenes of Citrus essential oils. The biocompatibility of the vesicles was assessed in vitro in human keratinocytes. Furthermore, the antimicrobial activity of the vesicles was tested while using different bacterial strains and a yeast: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans, respectively. The vesicles were small in size (~140 nm), slightly polydispersed (PI~0.31), highly negatively charged (~−73 mV), and able to incorporate high amounts of essential oil or citral (E%~86%). Pompia essential oil and citral exhibited antimicrobial activity against all of the assayed microorganisms, with P. aeruginosa being the least sensitive. Citral was slightly more effective than pompia essential oil against E. coli, S. aureus, and C. albicans. The incorporation of citral in vesicles improved its antifungal activity against C. albicans.

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“…Citrus fruits peels represent an important source of phenolic acids and flavonoids, mainly polymethoxyflavones (PMFs), flavanones and glycosylated flavanones [5,6]. Naringin (NA), a bioactive component of citrus species, is a glycosylated flavanone formed by naringenin (flavanone) and the disaccharide neohesperidose ( Figure 1).…”

Section: Introductionmentioning

confidence: 99%

“…Another advantage of nanoliposomes is cell-specific targeting, which is a prerequisite to ensure the adequate drug concentrations required for optimum therapeutic effects in the target site while minimizing adverse effects on healthy cells and tissues. Among them, ultradeformable liposomes have been found to be promising for herbal extracts delivery [6,24]. Since, this type of phospholipid vehicles increases the accumulation on the skin as well as reduces adverse effects.…”

Section: Introductionmentioning

confidence: 99%

A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy

Pleguezuelos-Villa

Mir-Palomo

Dı́ez-Sales

et al. 2018

Colloids and Surfaces B: Biointerfaces

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The article has 4636 words including ackwonledgment and references. The abstract has 127 words. There are 5 figures and 2 tables. Highlights Nanovesicles were small in size and monodispersed independently of the NA concentration. No citotoxity effects were observed in 3T3 fibroblasts treated with ultradeformable liposomes. Ultradeformable liposomes have the ability to reduce skin inflammation. Graphical abstract AbstractUltradeformable liposomes were formulated using naringin (NA), a flavanone glycoside, at different concentrations (3, 6 and 9 mg/mL). Nanovesicles were small size (~100 nm), regardless of the NA concentration used, and monodisperse (PI < 0.30). All formulations showed a high entrapment efficiency (~88%) and a highly negative zeta potential (around -30 mV). The selected formulations were highly biocompatible as confirmed by in vitro studies using 3T3 fibroblasts.In vitro assay showed that the amounts (%) of NA accumulated in the epidermis (~ 10%) could explain the anti-inflammatory properties of ultradeformable liposomes. In vivo studies confirmed the higher effectiveness of ultradeformable liposomes respect to betamethasone cream and NA dispersion in reducing skin inflammation in mice. Overall, it can conclude that NA ultradeformable liposomes can be considered as a promising formulation for the treatment of skin inflammatory diseases.

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Chemical characterization of Citrus limon var. pompia and incorporation in phospholipid vesicles for skin delivery

Cited by 34 publications

References 34 publications

Citrus limon (Lemon) Phenomenon—A Review of the Chemistry, Pharmacological Properties, Applications in the Modern Pharmaceutical, Food, and Cosmetics Industries, and Biotechnological Studies

Citrus limon (Lemon) Phenomenon—A Review of the Chemistry, Pharmacological Properties, Applications in the Modern Pharmaceutical, Food, and Cosmetics Industries, and Biotechnological Studies

Comparison between Citral and Pompia Essential Oil Loaded in Phospholipid Vesicles for the Treatment of Skin and Mucosal Infections

A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy

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