Chemical characterization, in vitro antioxidant, anti-cancer and enzyme inhibition activities of three edible mushroom species

Deveci, Ebru; Tel‐Çayan, Gülsen; Çayan, Fatih; Altınok, Buket; Aktaş, Sinan

doi:10.1007/s11694-023-02066-5

Cited by 3 publications

(4 citation statements)

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“…truncatus) can be used in the treatment of some cancers by interacting with farnesyltransferase, which is effective in tumor formation . The antioxidant, enzyme inhibition, antimicrobial, and anticancer properties of many varieties of extracts obtained from this mushroom have also been examined. , Craterellus tubaeformis (Fr.) Quél.…”

Section: Introductionmentioning

confidence: 99%

“… 19 The antioxidant, enzyme inhibition, antimicrobial, and anticancer properties of many varieties of extracts obtained from this mushroom have also been examined. 20 , 21 Craterellus tubaeformis (Fr.) Quél.…”

Section: Introductionmentioning

confidence: 99%

“… 22 The hexane, methanol, and water extracts of C. tubaeformis were investigated for antioxidant, anticancer, and anti-enzyme activities with chemical characterization by high-performance liquid chromatography (HPLC). 20 Hygrophorus pudorinus (Fr.) Fr.…”

Section: Introductionmentioning

confidence: 99%

“…To our knowledge, the only study on the bioactivities and chemical composition of H. pudorinus extracts reported that this mushroom was rich in fumaric acid and had antioxidant, anti-AChE, and antidiabetic activities. 20 Macrolepiota procera (Scop.) Singer (parasol mushroom) is a popular edible mushroom.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Polysaccharide Extracts of Four Edible Mushrooms and Determination of In Vitro Antioxidant, Enzyme Inhibition and Anticancer Activities

Deveci,

Tel-Çayan,

Çayan

et al. 2024

ACS Omega

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Mushroom polysaccharides are important bioactive compounds derived from mushrooms with various beneficial properties. In this study, the chemical characterization and bioactivities of polysaccharide extracts from four different edible mushrooms, Clavariadelphus truncatus Donk, Craterellus tubaeformis (Fr.) Queĺ., Hygrophorus pudorinus (Fr.) Fr., and Macrolepiota procera (Scop.) Singer were studied. Glucose (13.24−56.02%), galactose (14.18−64.05%), mannose (2.18−18.13%), fucose (1.21−5.78%), and arabinose (0.04−5.43%) were identified in all polysaccharide extracts by GC-MS (gas chromatography−mass spectrometry). FT-IR (Fourier transform infrared spectroscopy) confirmed the presence of characteristic carbohydrate patterns. 1 H NMR suggested that all polysaccharide extracts had αand β-Dmannopyranose, D-glucopyranose, D-galactopyranose, α-L-arabinofuranose, and α-L-fucopyranose residues. Approximate molecular weights of polysaccharide extracts were determined by HPLC (high-performance liquid chromatography). The best antioxidant activity was found in M. procera polysaccharide extract in DPPH • (1,1-diphenyl-2-picrylhydrazyl) scavenging (39.03% at 800 μg/ mL), CUPRAC (cupric reducing antioxidant capacity) (A 0.50 : 387.50 μg/mL), and PRAP (phosphomolybdenum reducing antioxidant power) (A 0.50 : 384.08 μg/mL) assays. C. truncatus polysaccharide extract showed the highest antioxidant activity in ABTS •+ scavenging (IC 50 : 734.09 μg/mL), β-carotene-linoleic acid (IC 50 : 472.16 μg/mL), and iron chelating (IC 50 : 180.35 μg/mL) assays. Significant anticancer activity was found in C. truncatus polysaccharide extract on HT-29 (IC 50 : 46.49 μg/mL) and HepG2 (IC 50 : 48.50 μg/mL) cell lines and H. pudorinus polysaccharide extract on the HeLa cell line (IC 50 : 51.64 μg/mL). Also, H. pudorinus polysaccharide extract possessed prominent AChE (acetylcholinesterase) inhibition activity (49.14% at 200 μg/mL).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characterization of Polysaccharide Extracts of Four Edible Mushrooms and Determination of In Vitro Antioxidant, Enzyme Inhibition and Anticancer Activities

Deveci,

Tel-Çayan,

Çayan

et al. 2024

ACS Omega

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Impact of key compounds derived from germinated tigernuts (Cyperus esculentus L.) on cells apoptosis and proliferation property

Wang,

Zhuang

et al. 2024

Food Measure

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Analysis of the Chemical and Medicinal Properties of Armillaria ostoyae (Agaricomycetes) Extracts and the Presence of Heavy Metals in Dry Basidiocarps

Petrovic,

Tosti,

Srbljak

et al. 2024

Int J Med Mushrooms

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We investigated the chemical and medicinal properties of methanolic and acetonic extracts of Armillaria ostoyae and the presence of heavy metals in its dry basidiocarps. The chemical content of extracts was analyzed with the HPLC-DAD-MS/MS method. According to our results, the most abundant mineral was potassium; the most abundant organic acid was malic acid; the most abundant carbohydrate was fructose, and the most abundant polyphenol was chlorogenic acid. The antimicrobial potential was evaluated using the microdilution assay, and the results ranged from 0.62 to 20 mg/mL. Antioxidant potential was studied by DPPH [half-maximal inhibitory concentration (IC50) of the methanolic extract was 619.67 μg/mL and of the acetonic extract was 533.65 μg/mL] and reducing power assays (the results ranged from 0.025 to 0.078 μg/mL). Total phenolic content was presented as gallic acid equivalent (methanolic extract, 6.12 mg GAE/g; acetonic extract, 3.99 mg GAE/g). The antidiabetic potential was explored by applying the α-amylase (the results ranged from 39.62 to 44.33%) and α-glucosidase assays (the results were in the range of 0.27-2.51%). The neuroprotective activity was asserted by the acetylcholinesterase inhibition assay (the results were in the range of 3.06-6.09%). The cytotoxic potential was investigated using the microtetrazolium assay, and the IC50 values ranged from 221.96 to > 400 μg/mL. Heavy metal content of the dry basidiocarps was evaluated using the AAS method and iron was the most abundant metal. A. ostoyae is a conditionally edible mushroom, which was not studied thoroughly before, thus this research will provide valuable knowledge about this species.

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Chemical characterization, in vitro antioxidant, anti-cancer and enzyme inhibition activities of three edible mushroom species

Cited by 3 publications

References 51 publications

Characterization of Polysaccharide Extracts of Four Edible Mushrooms and Determination of In Vitro Antioxidant, Enzyme Inhibition and Anticancer Activities

Characterization of Polysaccharide Extracts of Four Edible Mushrooms and Determination of In Vitro Antioxidant, Enzyme Inhibition and Anticancer Activities

Impact of key compounds derived from germinated tigernuts (Cyperus esculentus L.) on cells apoptosis and proliferation property

Analysis of the Chemical and Medicinal Properties of Armillaria ostoyae (Agaricomycetes) Extracts and the Presence of Heavy Metals in Dry Basidiocarps

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