Chemical characterization, antioxidant properties and anticancer activity of exopolysaccharides from Floccularia luteovirens

Liu, Zhengjie; Jiao, Yingchun; Lu, Hongyun; Shu, Xiaoli; Chen, Qihe

doi:10.1016/j.carbpol.2019.115432

Cited by 41 publications

(36 citation statements)

References 61 publications

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“…The presence of uronic acid groups in the polysaccharides can activate the hydrogen atom of the anomeric carbon [52]. In several studies, polysaccharides with higher uronic acid contents were found to generally have stronger antioxidant properties [34,54]. Our results showed that GLP-1 exhibited better antioxidant capacity despite the fact that the uronic acid content in GLP-1 was lower than that in GLP-2.…”

Section: Antioxidant Activities Of Glp-1 and Glp-2 In Vitromentioning

confidence: 55%

“…The polysaccharide GLP-1 had a weaker absorption peak at 1726.1 cm −1 than GLP-2, which might be due to the lower uronic acid content of GLP-1 (described above). The absorption peak at 1645.4 cm −1 for GLP-1 and that at 1658.2 cm −1 for GLP-2 indicated the presence of associated water [34,35]. The bands in the range of 1200-1500 cm −1 probably corresponded to the deformation vibrations of C-H and bending vibrations of C-OH [36].…”

Section: Ft-ir Spectra Of Glp-1 and Glp-2mentioning

confidence: 92%

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Purification, Physicochemical Properties, and Antioxidant Activities of Two Low-Molecular-Weight Polysaccharides from Ganoderma leucocontextum Fruiting Bodies

Guan

et al. 2021

Antioxidants

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Two low-molecular-weight polysaccharides (GLP-1 and GLP-2) were purified from Ganoderma leucocontextum fruiting bodies, and their physicochemical properties and antioxidant activities were investigated and compared in this study. The results showed that GLP-1 and GLP-2 were mainly composed of mannose, glucose, galactose, xylose, and arabinose, with weight-average molecular weights of 6.31 and 14.07 kDa, respectively. Additionally, GLP-1 and GLP-2 had a similar chain conformation, crystal structure, and molecular surface morphology. Moreover, GLP-1 exhibited stronger antioxidant activities than GLP-2 in five different assays: 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), hydroxyl radical, superoxide anion radical, ferric reducing antioxidant power (FRAP), and oxygen radical antioxidant capacity (ORAC). The main linkage types of GLP-1 were found to be →4)-α-D-Glcp-(1→, →4)-β-D-Glcp-(1→, →3)-β-D-Glcp-(1→, →6)-β-D-Galp-(1→, →6)-α-D-Glcp-(1→, →4,6)-α-D-Glcp-(1→, and Glcp-(1→ by methylation analysis and nuclear magnetic resonance (NMR) spectroscopy. In addition, GLP-1 could protect NIH3T3 cells against tert-butyl hydroperoxide (tBHP)-induced oxidative damage by increasing catalase (CAT) and glutathione peroxidase (GSH-Px) activities, elevating the glutathione/oxidized glutathione (GSH/GSSG) ratio, and decreasing the malondialdehyde (MDA) level. These findings indicated that GLP-1 could be explored as a potential antioxidant agent for application in functional foods.

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Section: Antioxidant Activities Of Glp-1 and Glp-2 In Vitromentioning

confidence: 55%

Section: Ft-ir Spectra Of Glp-1 and Glp-2mentioning

confidence: 92%

Purification, Physicochemical Properties, and Antioxidant Activities of Two Low-Molecular-Weight Polysaccharides from Ganoderma leucocontextum Fruiting Bodies

Guan

et al. 2021

Antioxidants

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“…The economic value of macrofungi may be enhanced by elucidating the relationships between the functions and bioactivity of their components. Numerous studies have shown that the bioactive constituents of macrofungi may prevent metabolic disorders and various diseases (De Silva et al, 2013;Liu, Jiao, Lu, Shu, & Chen, 2020;Roncero-Ramos & Delgado-Andrade, 2017). Thus, macrofungi extracts and their bioactive constituents could have extensive nutritional and therapeutic applications.…”

Section: Introductionmentioning

confidence: 99%

Macrofungi: A review of cultivation strategies, bioactivity, and application of mushrooms

Lou

et al. 2020

Comp Rev Food Sci Food Safe

Self Cite

112

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The production of macrofungi (mushrooms) as well as their economic value have been steadily increasing globally. The use of functional foods, dietary supplements, and traditional medicines derived from macrofungi is increasing as they have numerous health benefits as well as abundant nutrients. Macrofungi are diverse with complex and highly varied growth conditions and bioactive constituents, most macrofungal resources have not yet been fully explored and applicated, leading to an urgent need for appropriate strategies to address the problem. Increasing attention has been paid to the macrofungal cultivation and application, in particular, potential prebiotics. Herein, the present review comprehensively summarizes recent progress in the cultivation, newly identified bioactive constituents, and their effects on gut microbiota as well as the potential ways in which they affect human health. Moreover, the macrofungal food development is discussed to improve food nutritional value and change the quality characteristics of food. Finally, the review addresses consumer safety concerns and the prospective genetic manipulation of macrofungi. We hope that this review can provide a comprehensive research reference for ensuring the safety and efficacy, along with maximizing the value and profitability of macrofungi production.

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“…Zymosan is not easily degraded; therefore, it can cause oxidative stress after intraperitoneal injection. The overproduction of reactive oxygen species (ROS) could induce apoptosis by activating inflammatory cytokines; then it can cause sustained inflammatory reactions, overly release inflammatory mediators, and produce acute lung injury [4,7]. lack of obvious absorption at 260 and 280 nm indicated that there were little proteins or nucleic acids in the polysaccharides, and the weak absorption peak of 252−272 nm was caused by a carbonyl group.…”

Section: Introductionmentioning

confidence: 99%

Acetylated Polysaccharides From Pleurotus geesteranus Alleviate Lung Injury Via Regulating NF-κB Signal Pathway

Song

Zhang

2020

IJMS

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The present work investigated the anti-inflammatory, antioxidant, and lung protection effects of acetylated Pleurotus geesteranus polysaccharides (AcPPS) on acute lung injury (ALI) mice. The acetylation of AcPPS was successfully shown by the peaks of 1737 cm−1 and 1249 cm−1 by FTIR. The animal experiments demonstrated that lung damage can be induced by zymosan. However, the supplementation of AcPPS had potential effects on reducing lung index, remitting inflammatory symptoms (TNF-α, IL-1β, and IL-6), inhibiting NF-κB signal pathway based on up-regulating the level of IκBα and down-regulating p-IκBα level by Western blotting and immunofluorescence assay, preventing oxidative stress (ROS, SOD, GSH-Px, CAT, T-AOC, and MDA), reducing lipid accumulation (TC, TG, LDL-C, HDL-C, and VLDL-C), and alleviating lung functions by histopathologic observation. These results demonstrated that AcPPS might be suitable for natural food for prevention or remission in ALI.

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Chemical characterization, antioxidant properties and anticancer activity of exopolysaccharides from Floccularia luteovirens

Cited by 41 publications

References 61 publications

Purification, Physicochemical Properties, and Antioxidant Activities of Two Low-Molecular-Weight Polysaccharides from Ganoderma leucocontextum Fruiting Bodies

Purification, Physicochemical Properties, and Antioxidant Activities of Two Low-Molecular-Weight Polysaccharides from Ganoderma leucocontextum Fruiting Bodies

Macrofungi: A review of cultivation strategies, bioactivity, and application of mushrooms

Acetylated Polysaccharides From Pleurotus geesteranus Alleviate Lung Injury Via Regulating NF-κB Signal Pathway

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