Chemical characterization and prebiotic activity of fructo-oligosaccharides from Stevia rebaudiana (Bertoni) roots and in vitro adventitious root cultures

Lopes, Sheila Mara Sanches; Francisco, Mariane Grigio; Higashi, Bruna; Almeida, Rafaela Takako Ribeiro de; Krausová, Gabriela; Pilau, Eduardo Jorge; Gonçalves, José Eduardo; Gonçalves, Regina Aparecida Correia; Oliveira, Arildo José Braz de

doi:10.1016/j.carbpol.2016.07.043

Cited by 57 publications

(21 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The fermentation capacity of fructans as a substrate for microbiota is strain specific. Fructans derived from S. rebaudiana , especially those with a polymerization degree of <6 (carbohydrates with different-size chain), improved the growth of select microbial strains (bifidobacteria and lactobacilli) that are important for bowel function (58).…”

Section: Current Status Of Knowledgementioning

confidence: 99%

Effects of Sweeteners on the Gut Microbiota: A Review of Experimental Studies and Clinical Trials

Ruiz‐Ojeda

Plaza‐Díaz

Sáez-Lara

et al. 2019

Advances in Nutrition

262

254

View full text Add to dashboard Cite

The consumption of sugar-free foods is growing because of their low-calorie content and the health concerns about products with high sugar content. Sweeteners that are frequently several hundred thousand times sweeter than sucrose are being consumed as sugar substitutes. Although nonnutritive sweeteners (NNSs) are considered safe and well tolerated, their effects on glucose intolerance, the activation of sweet taste receptors, and alterations to the composition of the intestinal microbiota are controversial. This review critically discusses the evidence supporting the effects of NNSs, both synthetic sweeteners (acesulfame K, aspartame, cyclamate, saccharin, neotame, advantame, and sucralose) and natural sweeteners (NSs; thaumatin, steviol glucosides, monellin, neohesperidin dihydrochalcone, and glycyrrhizin) and nutritive sweeteners (polyols or sugar alcohols) on the composition of microbiota in the human gut. So far, only saccharin and sucralose (NNSs) and stevia (NS) change the composition of the gut microbiota. By definition, a prebiotic is a nondigestible food ingredient, but some polyols can be absorbed, at least partially, in the small intestine by passive diffusion: however, a number of them, such as isomalt, maltitol, lactitol, and xylitol, can reach the large bowel and increase the numbers of bifidobacteria in humans. Further research on the effects of sweeteners on the composition of the human gut microbiome is necessary.

show abstract

Section: Current Status Of Knowledgementioning

confidence: 99%

Effects of Sweeteners on the Gut Microbiota: A Review of Experimental Studies and Clinical Trials

Ruiz‐Ojeda

Plaza‐Díaz

Sáez-Lara

et al. 2019

Advances in Nutrition

262

254

View full text Add to dashboard Cite

show abstract

“…The MALDI-TOF mass spectra of fructans 1 , 2 and 3 (Figure 5) were similar to that of an inulin-type fructan and there was a mass difference of 162 between two neighboring ions, which corresponded to fructan/fructan residues [17,21,22]. The ion with maximum abundance at m / z 833 was assumed to be [Glu + 4Fru − H 2 O + Na] + .…”

Section: Resultsmentioning

confidence: 99%

Three Inulin-Type Fructans from Codonopsis pilosula (Franch.) Nannf. Roots and Their Prebiotic Activity on Bifidobacterium longum

Zhang

Cao

et al. 2018

Molecules

View full text Add to dashboard Cite

Radix Codonopsis, derived from the roots of Codonopsis pilosula (Franch.) Nannf., Codonopsis pilosula (Franch.) Nannf. Var. modesta (Nannf.) L.T. Shen and Codonopsis tangshen Oliv., has been used as traditional Chinese medicine for improving poor gastrointestinal function, treating gastric ulcers and chronic gastritis in China. Inulin-type fructans are carbohydrates consisting mainly of β (2→1) fructosyl-fructose links in chemical structure and exhibit a range of properties such as prebiotic activity, fat substitutes in low-calorie foods and disease-modifying effects. The prebiotic effects of inulin-type fructans are hypothesized to improve gastrointestinal function through alterations to gut microbiota composition and metabolism. In the present study, three inulin-type fructans with high degree of polymerization (DP = 16, 22, and 31) were isolated from the roots of Codonopsis pilosula (Franch.) Nannf. and their structures were confirmed by MALDI-TOF-MS, 1D- and 2D-NMR. The prebiotic activity of these fructans was evaluated by detecting growth stimulation on Bifidobacterium longum. The results demonstrated that three fructans at a concentration of 2.0 g/L exhibited significant growth stimulation on Bifidobacterium longum in a time-dependent manner (p < 0.01). The data indicated that inulin-type fructans in Radix Codonopsis could be used as potential prebiotics.

show abstract

“…Fructo-oligosaccharides (FOS) are commonly regarded as a type of prebiotics, favorably stimulating the growth of Bifidobacteria and Lactobacilli . FOS from Stevia rebaudiana roots enhanced the growth of specific strains of both Bifidobacteria and Lactobacilli , especially, with respect to their fermentation ability ( Sanches Lopes et al, 2016 ). FOS are reserve carbohydrates with important positive health effects and technological applications in the food industry.…”

Section: Discussionmentioning

confidence: 99%

Prebiotic Effect of Fructooligosaccharides from Morinda officinalis on Alzheimer’s Disease in Rodent Models by Targeting the Microbiota-Gut-Brain Axis

Chen

Yang

et al. 2017

Front. Aging Neurosci.

166

114

View full text Add to dashboard Cite

Gut microbiota influences the central nervous system disorders such as Alzheimer’s disease (AD). The prebiotics and probiotics can improve the host cognition. A previous study demonstrated that fructooligosaccharides from Morinda officinalis (OMO) exert effective memory improvements in AD-like animals, thereby considered as potential prebiotics; however, the underlying mechanism still remains enigma. Thus, the present study investigated whether OMO is effective in alleviating AD by targeting the microbiota-gut-brain axis. OMO was administered in rats with AD-like symptoms (D-galactose- and Aβ1-42-induced deficient rats). Significant and systematic deterioration in AD-like animals were identified, including learning and memory abilities, histological changes, production of cytokines, and microbial community shifts. Behavioral experiments demonstrated that OMO administration can ameliorate the learning and memory abilities in both AD-like animals significantly. AD parameters showed that OMO administration cannot only improve oxidative stress and inflammation disorder, but also regulate the synthesis and secretion of neurotransmitter. Histological changes indicated that OMO administration ameliorates the swelling of brain tissues, neuronal apoptosis, and down-regulation of the expression of AD intracellular markers (Tau and Aβ1-42). 16S rRNA sequencing of gut microbiota indicated that OMO administration maintains the diversity and stability of the microbial community. In addition, OMO regulated the composition and metabolism of gut microbiota in inflammatory bowel disease (IBD) mice model treated by overdosed antibiotics and thus showed the prebiotic potential. Moreover, gut microbiota plays a major role in neurodevelopment, leading to alterations in gene expression in critical brain and intestinal regions, thereby resulting in perturbation to the programming of normal cognitive behaviors. Taken together, our findings suggest that the therapeutic effect of the traditional medicine, M. officinalis, on various neurological diseases such as AD, is at least partially contributed by its naturally occurring chemical constituent, OMO, via modulating the interaction between gut ecology and brain physiology.

show abstract

Chemical characterization and prebiotic activity of fructo-oligosaccharides from Stevia rebaudiana (Bertoni) roots and in vitro adventitious root cultures

Cited by 57 publications

References 46 publications

Effects of Sweeteners on the Gut Microbiota: A Review of Experimental Studies and Clinical Trials

Effects of Sweeteners on the Gut Microbiota: A Review of Experimental Studies and Clinical Trials

Three Inulin-Type Fructans from Codonopsis pilosula (Franch.) Nannf. Roots and Their Prebiotic Activity on Bifidobacterium longum

Prebiotic Effect of Fructooligosaccharides from Morinda officinalis on Alzheimer’s Disease in Rodent Models by Targeting the Microbiota-Gut-Brain Axis

Contact Info

Product

Resources

About