Chemical Characteristics and Antioxidant Activity of Arctostaphylos uva-ursi L. Spreng. at the Southern Border of the Geographical Range of the Species in Europe

Sugier, Piotr; Sęczyk, Łukasz; Sugier, Danuta; Krawczyk, R.; Wójcik, Małgorzata; Czarnecka, Joanna; Okoń, Sylwia; Plak, Andrzej

doi:10.3390/molecules26247692

Cited by 14 publications

(33 citation statements)

References 68 publications

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“…The concentration of this metabolite in the EE was over 15% higher than in the WE. The hyperoside concentrations presented in this paper are significantly higher than those reported for heathland populations [ 10 ]. Hyperoside is an active compound found in plants of the genera Hypericum and Crataegus exhibiting antioxidant, anticancer, and anti-inflammatory activities [ 61 , 62 , 63 ].…”

Section: Resultscontrasting

confidence: 74%

“…The analysis of the ALE showed a variation in the picein concentration, i.e., from 1.13 mg g −1 to 1.98 mg g −1 in the WE and from 0.69 mg g −1 to 1.75 mg g −1 in the samples extracted by ethanol ( Figure 7 ). This picein concentration in the EE is lower than in raw material taken from heathland populations, where it exceeded 2.5 mg g −1 [ 10 ]. Picein is a natural antioxidant and can serve a function of a potent neuroprotectant [ 57 ].…”

Section: Resultsmentioning

confidence: 99%

“…New sources of secondary metabolites of medicinal plants are being widely sought [ 6 , 7 ], and introduction of medicinal plants into field conditions is carried out to obtain chemically interesting standardized raw material in controlled conditions [ 6 , 7 , 8 ]. However, there are rare attempts to search for chemically valuable bearberry ecotypes in natural habitats and to analyze variations within and among natural bearberry populations [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Variation in Population and Solvents as Factors Determining the Chemical Composition and Antioxidant Potential of Arctostaphylos uva-ursi (L.) Spreng. Leaf Extracts

2022

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The bearberry Arctostaphylos uva-ursi (L.) Spreng. has a long history of ethnopharmacological use. This species has been used in folk medicine for centuries as a rich source of raw material abundant in secondary metabolites and is important for medicinal and pharmacological purposes. The plant is a source of herbal material—Uvae ursi folium, which is highly valued and sought by pharmaceutical and cosmetic industries. The studied bearberry leaves can be classified as a suitable herbal material for use in pharmacy; therefore, the investigated populations can be a potentially valuable source of plant material for cultivation and can be used in in vitro cultures and in biotechnological processes. The objective of this study was to characterize the variability of the phytochemical composition and antioxidant activity of water and ethanol bearberry extracts from raw material collected from different natural populations. In each of the twelve A. uva-ursi sites, three leaf samples were collected and analyzed. The water extracts from bearberry leaves were characterized by similar concentration of arbutin (77.64–105.56 mg g−1) and a significantly higher concentration of hydroquinone (6.96–13.08 mg g−1) and corilagin (0.83–2.12 mg g−1) in comparison with the ethanol extracts −77.21–103.38 mg g−1, 10.55–16.72 mg g−1, 0.20–1.54 mg g−1, respectively. The concentration of other metabolites in the water extracts was significantly lower in comparison with the ethanol extracts. In the case of the water extracts, a significant effect of not only total phenolic compounds, but also hydroquinone on the antioxidant parameters, was observed, which indicates the solvent-related activity of these metabolites. Therefore, it is suggested that special attention should be paid to the concentration of not only arbutin, but also hydroquinone in Uvae ursi folium. The latter metabolite serving a very important function as an active bearberry ingredient should be controlled not only in alcoholic extracts but also in water extracts, since bearberry leaves are applied as infusions and decoctions. The results presented in this paper can contribute to appropriate selection of plant material for pharmaceutical, cosmetic, and food industries, with special emphasis on the antioxidant activity of different types of extracts.

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Section: Resultscontrasting

confidence: 74%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Variation in Population and Solvents as Factors Determining the Chemical Composition and Antioxidant Potential of Arctostaphylos uva-ursi (L.) Spreng. Leaf Extracts

2022

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“…vary in specimens located at the southern border of the species’ geographical range in Europe. Bearberry extracts from plants growing in two different habitat types—heathlands and pine forests—showed a wide range of variation, especially in the concentration of hyperoside, corilagin, and methylartutin and the total flavonoid contents [ 6 ]. In addition to arbutin, bearberry can be a valuable source of phenolic compounds, which are mainly responsible for the antioxidant properties of extracts.…”

mentioning

confidence: 99%

“…In addition to arbutin, bearberry can be a valuable source of phenolic compounds, which are mainly responsible for the antioxidant properties of extracts. The high content of phenols and high values of antioxidant parameters indicate the potential for bearberry leaves to be used as a powerful natural source of antioxidants in herbal preparations [ 6 ].…”

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confidence: 99%