Chemical changes in the rat brain following escape training

Gold, Martin; Altschuler, Henry; Kleban, Morton H.; Lawton, M. Powell

doi:10.3758/bf03329156

Cited by 7 publications

(6 citation statements)

References 6 publications

(7 reference statements)

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“…This observation, when compared with the previous experiments on supernatant RNA Gold, et al, 1969) has some definite implications. Free or loosely bound RNA molecules would be present in the supernatant.…”

Section: Correlations Of Brain Chestzistry With Extincrion Behaviorsupporting

confidence: 70%

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Neurochemical Changes in Brains of Albino Rats Resulting from Avoidance Learning

Kleban¹,

Gold²,

Altschuler³

et al. 1971

Psychol Rep

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Summasy.-To observe the effects of avoidance training on the brain chemistry of trained rats, 36 Wistar albino rats, 60-75 days old, were run in an automated straight-runway maze. 12 Ss received limited avoidance training followed immediately by extinction training for the avoidance response. 12 other Ss received limited avoidance training only, and 12 Ss acted as non-trained controls. Following rraining, each S's brain was removed and sectioned into three gross anatomical parts: cerebrum, brain stem, and cerebellum. Chemical analyses for RNA, protein, and total nitrogen were performed on each brain section for each animal. Significant increases in cerebrum, brain stem, and cerebellum RNA were found for bo:h trained groups. Such differences in RNA were strongly present in the brain stem and cerebrum but were nonsignificant for the cerebellum. Brain proteic showed significant increases as a result of the interaction oC cerebellum with avoidance training. Total nitrogen levels were unaltered. Two significant correlations obtained between neuro-chemistry and behavior, a zero-order correlation between brain-stem RNA and extinction behavior and a multiple correlation among brain-stem KNA, cerebral protein, and extinction behavior.

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Section: Correlations Of Brain Chestzistry With Extincrion Behaviorsupporting

confidence: 70%

“…before sacrificing, a time interval during which we found protein synthesis to occur (Gold, et al, 1969). The avoidance training task was 0-sec.…”

Section: P7otoco1mentioning

confidence: 99%

Neurochemical Changes in Brains of Albino Rats Resulting from Avoidance Learning

Kleban¹,

Gold²,

Altschuler³

et al. 1971

Psychol Rep

Self Cite

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show abstract

“…This would be equivalent to 1.5 mg of protein/g wet tissue. In the aforementioned study (Gold et al, 1969), the protein increase, above that of the rats immediately killed after training, was about 2.5 mg/g wet weight after 2 h.…”

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confidence: 99%

“…(Gold et al, 1969) conducted in our laboratory using an escape-training paradigm showed no increase in the calculated NPN in rats sacrificed immediately after training when compared to a nontrained control group. A drop in the calculated NPN was noted after a 2-h posttraining interval with a concomitant rise in protein content in a saline extract from total brain.…”

mentioning

confidence: 99%

“…In two previous reports from our laboratory (Gold et al, 1969(Gold et al, , 1970 nonprotein nitrogen (NPN) was estimated by subtracting the contribution of protein nitrogen, by assuming the nitrogen content to be 16%. The first report (Gold et aI, 1969) showed that the calculated NPN value was significantly depressed 2 h after escape training, but not immediately after termination of the training.…”

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confidence: 99%

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