2008
DOI: 10.1016/j.urolonc.2007.05.013
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Chemical castration with intratesticular injection of 20% hypertonic saline: A minimally invasive method

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Cited by 23 publications
(24 citation statements)
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“…A castração química é um processo no qual substâncias químicas produzem inflamação, fibrose e lesão definitiva nas estruturas do aparelho reprodutor masculino, levando à redução da espermatogênese e nível sérico de andrógenos (KUTZLER e WOOD, 2006). Tais métodos são considerados irreversíveis e possibilitam redução nos níveis de dor e maior velocidade de recuperação quando comparados aos procedimentos tradicionais (COHEN et al, 1990;EMIR et al, 2008;AHMED e AL-BADRANY, 2009).…”
Section: Castração Químicaunclassified
“…A castração química é um processo no qual substâncias químicas produzem inflamação, fibrose e lesão definitiva nas estruturas do aparelho reprodutor masculino, levando à redução da espermatogênese e nível sérico de andrógenos (KUTZLER e WOOD, 2006). Tais métodos são considerados irreversíveis e possibilitam redução nos níveis de dor e maior velocidade de recuperação quando comparados aos procedimentos tradicionais (COHEN et al, 1990;EMIR et al, 2008;AHMED e AL-BADRANY, 2009).…”
Section: Castração Químicaunclassified
“…15 As result, in some cases, the interstitial portion regenerated after an initial phase of testicular atrophy and this led to secondary male behavior, which caused management problems of the animals Due to the above complications caused by the use of aforementioned chemicals, an effective chemosterilizing agent is yet to be established. 18,34 For the past 10-years, an attempt has been made to induce sterilization by intratesticular injection of calcium chloride (CaCl 2 ), [2][3][4]12,30,62 Zinc gluconate (Neutersol) 22,63 and 20% hypertonic saline solution 64,65 in bull, cat, dog, donkey, goat and albino mice. As indicated above, different chemical agents were tried and used over the past years.…”
Section: Inorganic Chemosterilantsmentioning
confidence: 99%
“…In a study, 20% hypertonic saline solution was injected bilaterally into the rat testes at different areas with a total amount of about 0.5 to 1 ml in each testis and reported that the coagulation necrosis was observed in all testes. 22,34,64 Kwak et al 65 revealed that severe degenerative changes were seen in testicular seminiferous tubules and massive infiltration of inflammatory immune cells in animals injected with hypertonic saline solution. Additionally, researchers indicated that intratesticular hypertonic saline injection seems to be an alternative method to orchiectomy and surgical castration.…”
Section: Sodium Chloride Solutionmentioning
confidence: 99%
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“…Thus, secondary male characteristics such as roaming, marking, aggression, or mounting may be displayed (Massei and Miller, 2013 Kwak and Lee, (2013) revealed that severe degenerative changes in testicular seminiferous tubules and massive infiltration of immune cells in hypertonic saline group. Additionally researchers indicated that "intratesticular hypertonic saline injection seems to be an alternative method in the future to its rivals such as orchiectomy and medical castration" but that further laboratory work would be required to ascertain the potential utility of this approach in dogs (Emir et al, 2008).…”
mentioning
confidence: 99%