Chemical burn caused by high-concentration hydrofluoric acid: a case that followed a lethal course

Onohara, Takayuki; Komine, Mayumi; Yoshidomi, Yuya; Amari, Kaori; Fujita, Ryo; Matsumoto, Yasushi; Koyama, Takashi; Koga, Mika; Mitsumizo, Shinji; Satake, Yoshiyasu; Masumoto, Kazuyuki; Matsunaga, Taiki; Mae, Takao; Fujita, Naoya

doi:10.15761/god.1000157

Cited by 3 publications

(9 citation statements)

References 9 publications

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“…Reduced motor activity, decreased sensitivity and ischemia provoked by arterial vasospasm might be additional symptoms in fingers’ burns [ 53 ]. Necrotic dermal tissue detached from the subcutaneous tissue has been observed in third-degree skin burns provoked by 50% HF acid [ 19 ].…”

Section: Corrosiveness and Toxicitymentioning

confidence: 99%

“…Cases with expressed systemic disorder including electrolyte imbalance, enzyme inhibition, symptoms of hypovolemic shock, multiorgan failure, acute respiratory failure and numerous ventricular fibrillation or asystole, in which resuscitation procedures have been ineffective, have a lethal outcome [ 15 ], [ 18 ], [ 19 ].…”

Section: Corrosiveness and Toxicitymentioning

confidence: 99%

“…Due to the high affinity of fluoride ion towards calcium and magnesium, and formation of insoluble salts, massive systemic electrolyte imbalance, which is difficult to counterbalance, may occur [ 53 ], [ 60 ]. This includes hypocalcemia, hypomagnesemia [ 45 ], hyperkalemia [ 14 ], [ 15 ], [ 19 ] or hypokalemia [ 2 ], [ 61 ], [ 62 ], fluorosis and metabolic acidosis [ 1 ], [ 19 ]. Enzyme inhibition and coagulation disorders [ 15 ], [ 22 ] are common findings as well.…”

Section: Corrosiveness and Toxicitymentioning

confidence: 99%

“…Additionally, free fluoride ions activate myocardial adenylyl cyclase thus increasing cyclic adenosine monophosphate (cAMP), which stimulates the myocardium inducing refractory ventricular fibrillation. Severe fluoride intoxication may provoke sudden cardiac arrest with a lethal outcome [ 1 ], [ 2 ], [ 13 ], [ 16 ], [ 18 ], [ 19 ], [ 23 ].…”

Section: Corrosiveness and Toxicitymentioning

confidence: 99%

“…Chronic symptoms may even occur several months after HF ingestion [ 12 ] or may persist with months after the long-time respiratory exposure [ 3 ]. Sometimes, systemic intoxication has a lethal outcome [ 15 ], [ 16 ], [ 17 ], [ 18 ], [ 19 ], [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Hydrofluoric Acid: Burns and Systemic Toxicity, Protective Measures, Immediate and Hospital Medical Treatment

Valjakova

Korunoska-Stevkovska

Georgieva

et al. 2018

Open Access Maced J Med Sci

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BACKGROUND:Hydrofluoric acid is a commonly used chemical in many industrial branches, but it can also be found as an ingredient in household products such as cleaning agents. Possessing high corrosive potential, HF acid causes burns and tissue necrosis, while when absorbed and distributed through the bloodstream, its extremely high toxic potential is expressed. Acute symptoms are often followed by pain, particularly in the case of skin burns, which intensiveness does not often correlate with the expressiveness of the clinical findings. Even exposure to low-concentrated solutions or gasses, or low-doses of high-concentrated acid, may provoke delayed systemic disorder which may eventually have a lethal outcome.AIM:Therefore, having information regarding the possible hazardous effects of hydrofluoric acid usage, a variety of symptoms, as well as a treatment approach, is of great importance in the case of HF exposure.METHODS:Available scientific articles published in literature databases, scientific reports and governmental recommendations from the internet websites, written in English, using the following search terms “Hydrofluoric acid, skin burns, eye injury, ingestion, inhalation, systemic toxicity, decontamination, antidote, medical treatment” have been reviewed.RESULTS:This review is useful not only for physicians but for everyone who may come in contact with a person exposed to HF acid.CONCLUSION:It highlights the mechanism of action, presents the acute and chronic symptoms, personal and general protective measures and devices that should be used, as well as decontamination procedures, immediate, antidote and hospital medical treatment.

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Section: Corrosiveness and Toxicitymentioning

confidence: 99%

Section: Corrosiveness and Toxicitymentioning

confidence: 99%

Section: Corrosiveness and Toxicitymentioning

confidence: 99%

Section: Corrosiveness and Toxicitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Hydrofluoric Acid: Burns and Systemic Toxicity, Protective Measures, Immediate and Hospital Medical Treatment

Valjakova

Korunoska-Stevkovska

Georgieva

et al. 2018

Open Access Maced J Med Sci

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Acute lung and lower respiratory tract damage after inhalation exposure to hydrogen fluoride

Паринов

2022

Med.-biol. soc.-psihol. probl. bezop. črezvyčajnyh situac.

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Relevance. Hydrogen fluoride is a highly active chemical substance widely used in industry for production of inorganic fluorides, organofluorine compounds, in the processing of aluminum, stainless steel and alloys. The chemical properties of hydrogen fluoride determine its ability to have a destructive effect on the tissues of the human body and high toxicity with local and systemic exposure. Hydrogen fluoride poisoning is severe and difficult to treat. Clarification of the clinical picture and the search for new methods of treating lesions with hydrogen fluoride are of great importance for protecting the health of workers in chemical industries and eliminating the consequences of technogenic accidents.Intention. To consider the features of the observed clinical case of severe damage to the lungs and lower respiratory tract after inhalation exposure to hydrogen fluoride and treatment methods that made it possible to achieve favorable clinical results. Methodology. The article discusses clinically important chemical properties of hydrogen fluoride, the mechanisms and manifestations of characteristic lesions developing in the human body with various routes of exposure. Modern approaches to the treatment of patients exposed to hydrogen fluoride are outlined.Results and Discussion. Inhalation of gas mixtures, even with low concentrations of hydrogen fluoride, can lead to severe inflammatory-necrotic lung damage with interstitial pneumonia (chemical pneumonitis), adult respiratory distress syndrome, and severe respiratory failure. Improvement of clinical condition of the affected person in the observed case was achieved via complex treatment with glucocorticosteroids, antimicrobial agents, calcium gluconate inhalations. A key role in the patient’s treatment was played by long-term replacement of the impaired function of the lungs using extracorporeal membrane oxygenation.Conclusion. In severe forms of acute damage to the lungs and lower respiratory tract as a result of inhaled exposure to hydrogen fluoride, clinical recovery and improvement in the quality of life of the injured can be achieved through complex therapy using glucocorticosteroids, antibacterial agents, specific antidotes (calcium gluconate) and prolonged replacement of the respiratory function via artificial ventilation and extracorporeal membrane oxygenation.

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A Case of Severe Poisoning due to Oral Hydrofluoric Acid Ingestion that Could Survive with Timely Effective Treatments

Küllüoğlu¹,

Lüleyap²,

Çiçek³

et al. 2022

buchd

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Chemical burn caused by high-concentration hydrofluoric acid: a case that followed a lethal course

Cited by 3 publications

References 9 publications

Hydrofluoric Acid: Burns and Systemic Toxicity, Protective Measures, Immediate and Hospital Medical Treatment

Hydrofluoric Acid: Burns and Systemic Toxicity, Protective Measures, Immediate and Hospital Medical Treatment

Acute lung and lower respiratory tract damage after inhalation exposure to hydrogen fluoride

A Case of Severe Poisoning due to Oral Hydrofluoric Acid Ingestion that Could Survive with Timely Effective Treatments

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