Chemical and Visual Stability of Amphotericin B in 5% Dextrose Injection Stored at 4 Degrees C for 35 Days

Mitrano, Francis P.; Outman, William R.; Baptista, Richard J.; Palombo, John D.

doi:10.1093/ajhp/48.12.2635

Cited by 3 publications

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“…by autolytic processes cannot be ruled out completely. Amphotericin B, however, is stable at 4 C for at least 24 h. 37,38 There is even no loss or degradation of amphotericin B during storage for 35 days at 4 C. 39 In plasma, liberated amphotericin B (i.e. free and plasma protein bound amphotericin B) and lipid-formulated amphotericin B (liposomal or colloidal amphotericin B) can be separated by SPE.…”

Section: Discussionmentioning

confidence: 99%

Amphotericin B tissue distribution in autopsy material after treatment with liposomal amphotericin B and amphotericin B colloidal dispersion

Vogelsinger

2006

Journal of Antimicrobial Chemotherapy

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Section: Discussionmentioning

confidence: 99%

Amphotericin B tissue distribution in autopsy material after treatment with liposomal amphotericin B and amphotericin B colloidal dispersion

Vogelsinger

2006

Journal of Antimicrobial Chemotherapy

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“…Similarly, it was inactive after being stored in water at 2ЊC for 48 h in the dark. In contrast, storage at 4ЊC in 5% glucose protected it from degradation, as measured by HPLC (112,121,143). It was stable when solubilized in serum as well but not when dissolved in dimethyl sulfoxide.…”

Section: Chemical Stabilitymentioning

confidence: 98%

Carrier effects on biological activity of amphotericin B.

Brajtburg

Bolard

1996

Clinical Microbiology Reviews

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Carrier effects on biological activity of amphotericin B

1996

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Amphotericin B (AmB), the drug of choice for the treatment of most systemic fungal infections, is marketed under the trademark Fungizone, as an AmB-deoxycholate complex suitable for intravenous administration. The association between AmB and deoxycholate is relatively weak; therefore, dissociation occurs in the blood. The drug itself interacts with both mammalian and fungal cell membranes to damage cells, but the greater susceptibility of fungal cells to its effects forms the basis for its clinical usefulness. The ability of the drug to form stable complexes with lipids has allowed the development of new formulations of AmB based on this property. Several lipid-based formulations of the drug which are more selective in damaging fungal or parasitic cells than mammalian cells and some of which also have a better therapeutic index than Fungizone have been developed. In vitro investigations have led to the conclusion that the increase in selectivity observed is due to the selective transfer of AmB from lipid complexes to fungal cells or to the higher thermodynamic stability of lipid formulations. Association with lipids modulates AmB binding to lipoproteins in vivo, thus influencing tissue distribution and toxicity. For example, lipid complexes of AmB can be internalized by macrophages, and the macrophages then serve as a reservoir for the drug. Furthermore, stable AmB-lipid complexes are much less toxic to the host than Fungizone and can therefore be administered in higher doses. Experimentally, the efficacy of AmB-lipid formulations compared with Fungizone depends on the animal model used. Improved therapeutic indices for AmB-lipid formations have been demonstrated in clinical trials, but the definitive trials leading to the selection of an optimal formulation and therapeutic regimen have not been done.

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Chemical and Visual Stability of Amphotericin B in 5% Dextrose Injection Stored at 4 Degrees C for 35 Days

Cited by 3 publications

References 0 publications

Amphotericin B tissue distribution in autopsy material after treatment with liposomal amphotericin B and amphotericin B colloidal dispersion

Amphotericin B tissue distribution in autopsy material after treatment with liposomal amphotericin B and amphotericin B colloidal dispersion

Carrier effects on biological activity of amphotericin B.

Carrier effects on biological activity of amphotericin B

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