Chemical and toxicological evolution of the antibiotic sulfamethoxazole under ozone treatment in water solution

Gómez-Ramos, María del Mar; Mezcúa, Milagros; Agüera, Ana; Fernández‐Alba, Amadeo R.; Gonzalo, Soledad; Rodrı́guez, Antonio Rodrı́guez; Rosal, Roberto

doi:10.1016/j.jhazmat.2011.04.072

Cited by 55 publications

(61 citation statements)

References 33 publications

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“…Hydroxylation is a well-reported pathway during the degradation of SMX by various AOP. Similar hydroxy-TBPs have been previously described as by-products of TiO 2 photocatalysis, photo-Fenton, ultrasound/ozone oxidation, ferrous-activated persulfate oxidation, thermo activated persulfate oxidation, ozonation, catalytic ozonation and electrochemical oxidation, among others [65][66][67][68][69][70][71][72][73].…”

Section: Antimicrobial Activity and Oxidation Mechanism: A Water Treamentioning

confidence: 79%

Magnetic carbon xerogels for the catalytic wet peroxide oxidation of sulfamethoxazole in environmentally relevant water matrices

Ribeiro

Frontistis

Mantzavinos

et al. 2016

Applied Catalysis B: Environmental

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a b s t r a c tNovel magnetic carbon xerogels consisting of interconnected carbon microspheres with iron and/or cobalt microparticles embedded in their structure were developed by a simple route. As inferred from the characterization data, materials with distinctive properties may be directly obtained upon inclusion of iron and/or cobalt precursors during the sol-gel polymerization of resorcinol and formaldehyde, followed by thermal annealing. The unique properties of these magnetic carbon xerogels were explored in the catalytic wet peroxide oxidation (CWPO) of an antimicrobial agent typically found throughout the urban water cycle -sulfamethoxazole (SMX).A clear synergistic effect arises from the inclusion of cobalt and iron in carbon xerogels (CX/CoFe), the resulting magnetic material revealing a better performance in the CWPO of SMX at the ppb level (500 g L −1 ) when compared to that of monometallic carbon xerogels containing only iron or cobalt. This effect was ascribed to the increased accessibility of highly active iron species promoted by the simultaneous incorporation of cobalt.The performance of the CWPO process in the presence of CX/CoFe was also evaluated in environmentally relevant water matrices, namely in drinking water and secondary treated wastewater, considered in addition to ultrapure water. It was found that the performance decreases when applied to more complex water and wastewater samples. Nevertheless, the ability of the CWPO technology for the elimination of SMX in secondary treated wastewater was unequivocally shown, with 96.8% of its initial content being removed after 6 h of reaction in the presence of CX/CoFe, at atmospheric pressure, room temperature (T = 25 • C), pH = 3, [H 2 O 2 ] 0 = 500 mg L −1 and catalyst load = 80 mg L −1 . A similar performance (97.8% SMX removal) is obtained in 30 min when the reaction temperature is slightly increased up to 60 • C in an ultrapure water matrix. Synthetic water containing humic acid, bicarbonate, sulphate or chloride, was also tested. The results suggest the scavenging effect of the different anions considered, as well as the negative impact of dissolved organic matter typically found in secondary treated wastewater, as simulated by the presence of humic acid.An in-situ magnetic separation procedure was applied for catalyst recovery and re-use during reusability cycles performed to mimic real-scale applications. CWPO runs performed with increased SMX 171 concentration (10 mg L −1 ), under a water treatment process intensification approach, allowed to evaluate the mineralization levels obtained, the antimicrobial activity of the treated water, and to propose a degradation mechanism for the CWPO of SMX.

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Section: Antimicrobial Activity and Oxidation Mechanism: A Water Treamentioning

confidence: 79%

Magnetic carbon xerogels for the catalytic wet peroxide oxidation of sulfamethoxazole in environmentally relevant water matrices

Ribeiro

Frontistis

Mantzavinos

et al. 2016

Applied Catalysis B: Environmental

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“…S7 and S8), P-155 and P-189 were identified as 4-sulfonylcyclohexa-2,5-dien-1-imine and hydroxysulfanilic acid, respectively. P-189, as a well-known product, had been identified in various catalytic PS processes Qi et al, 2014), nevertheless, P-155 was only found in ozonation process (Gómez-Ramos et al, 2011). In addition, P-155 and P-189 could be further transformed as aniline (P-93, m/z = 94…”

Section: Degradation Products and Pathways Of Smx In Ha/fe(ii)/pms Prmentioning

confidence: 99%

Efficient degradation of sulfamethoxazole by the Fe(II)/HSO5− process enhanced by hydroxylamine: Efficiency and mechanism

Liu

Han

et al. 2017

Journal of Hazardous Materials

158

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Fenton or Fenton-like processes have been regarded as feasible methods to degrade a wide variety of contaminants by generating reactive species, but the efficiency is highly affected by the slow transformation from Fe(III) to Fe(II) as well as pH. This study proposed a method by adding hydroxylamine (HA) to the Fe(II)/HSO5 -(Fe(II)/PMS) process to accelerate the degradation of contaminants, selecting a broad-spectrum sulfonamide antibiotic -

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“…Huerta-Fontela et al (2012) showed that disinfection by-products are produced after chlorine oxidation of amphetaminetype compounds at a drinking water treatment plant but in most studies the fate of the parent compound is monitored and the transformation products are generally not identified nor quantified (Celiz et al, 2009). It has been shown however that degradation by-products often persist after the parent compound has been completely removed and in some cases they are more toxic to aquatic organisms than the parent compound (Dantas et al, 2007;Gomez-Ramos et al, 2011;Rosal et al, 2010). Since it is not economically feasible to implement an ozonation system to supply enough ozone for complete mineralization, before ozone is implemented at WWTPs for either disinfection purposes or for the removal (or transformation) of CECs, the potential oxidation transformation products (OTPs) must first be investigated.…”

Section: Introductionmentioning

confidence: 99%

Ozonation of wastewater: Removal and transformation products of drugs of abuse

Rodayan

Segura

Yargeau

2014

Science of The Total Environment

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• The ozonation of six drugs of abuse and one human drug metabolite was carried out.• Drug removals vary between 3 and 50% for the ozone doses tested.• The main transformation products of the drugs of abuse were identified.• The most plausible structure of a transformation product of MDMA was elucidated. a b s t r a c t a r t i c l e i n f o In this study amphetamine, methamphetamine, methylenedioxymethamphetamine (MDMA), cocaine (COC), benzoylecgonine (BE), ketamine (KET) and oxycodone (OXY) in wastewater at concentrations of 100 μgL −1 were subjected to ozone to determine their removals as a function of ozone dose and to identify significant oxidation transformation products (OTPs) produced as a result of ozonation. A method based on high resolution mass spectrometry and differential analysis was used to facilitate and accelerate the identification and structural elucidation of the transformation products. The drug removal ranged from 3 to 50% depending on the complexity of the matrix and whether a mixture or individual drugs were ozonated. Both transient and persistent oxidation transformation products were identified for MDMA, COC and OXY and their chemical formulae were determined. Three possible structures of the persistent transformation product of MDMA (OTP-213) with chemical formula C 10 H 16 O 4 N, were determined based on MS n mass spectra and the most plausible structure (OTP-213a) was determined based on the chemistry of ozone. These results indicate that ozone is capable of removing drugs of abuse from wastewater to varying extents and that persistent transformation products are produced as a result of treatment.

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Chemical and toxicological evolution of the antibiotic sulfamethoxazole under ozone treatment in water solution

Cited by 55 publications

References 33 publications

Magnetic carbon xerogels for the catalytic wet peroxide oxidation of sulfamethoxazole in environmentally relevant water matrices

Magnetic carbon xerogels for the catalytic wet peroxide oxidation of sulfamethoxazole in environmentally relevant water matrices

Efficient degradation of sulfamethoxazole by the Fe(II)/HSO5− process enhanced by hydroxylamine: Efficiency and mechanism

Ozonation of wastewater: Removal and transformation products of drugs of abuse

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