Chemical and topographical patterning for directed cell attachment

Craighead, Harold G.; James, Conrad D.; Turner, A. M.P.

doi:10.1016/s1359-0286(01)00005-5

Cited by 215 publications

(175 citation statements)

References 63 publications

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“…The results suggest that micro-patterning and nano-texturing may be effective in controlling astrocyte interactions with implant materials for long-term implantations. 209,210 Intercellular signaling is critical for the normal development and physiology of the CNS. Intracellular calcium elevation in one astrocyte caused by neurotransmitters can propagate to other neighboring astrocytes and induce an intercellular calcium wave.…”

Section: Vc Glial Cell Biology On a Chipmentioning

confidence: 99%

Biology on a Chip: Microfabrication for Studying the Behavior of Cultured Cells

Tourovskaia

Folch

2003

Crit Rev Biomed Eng

173

140

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The ability to culture cells in vitro has revolutionized hypothesis testing in basic cell and molecular biology research and has become a standard methodology in drug screening and toxicology assays. However, the traditional cell culture methodology-consisting essentially of the immersion of a large population of cells in a homogeneous fluid medium-has become increasingly limiting, both from a fundamental point of view (cells in vivo are surrounded by complex spatiotemporal microenvironments) and from a practical perspective (scaling up the number of fluid handling steps and cell manipulations for high-throughput studies in vitro is prohibitively expensive). Micro fabrication technologies have enabled researchers to design, with micrometer control, the biochemical composition and topology of the substrate, the medium composition, as well as the type of neighboring cells surrounding the microenvironment of the cell. In addition, microtechnology is conceptually well suited for the development of fast, low-cost in vitro systems that allow for high-throughput culturing and analysis of cells under large numbers of conditions. Here we review a variety of applications of microfabrication in cell culture studies, with an emphasis on the biology of various cell types.

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Section: Vc Glial Cell Biology On a Chipmentioning

confidence: 99%

Biology on a Chip: Microfabrication for Studying the Behavior of Cultured Cells

Tourovskaia

Folch

2003

Crit Rev Biomed Eng

173

140

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“…[1][2][3][4][5][6][7][8][9][10][11][12] This has led to the discovery that micro-and nanotopology causes cells to elongate, [9] align to the direction of the surface pattern, [9,[13][14] to rearrange the extracellular matrix in contact with the surface, [11,15] and to internally re-organize cellular components. [9,12] It is also possible that the topography can illicit varying cellular responses.…”

Section: Introductionmentioning

confidence: 99%

Directional Alignment of MG63 Cells on Polymer Surfaces Containing Point Microstructures

Mills

Fernandez

Martínez

et al. 2007

Small

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MG63 cells cultured on regular arrays of point microstructures (posts and holes) are shown to preferentially align at certain angles to the pattern of the structures, at 08, 308, and 458 in particular. The effect is found to be more pronounced for post rather than hole structures (although no significant difference is found for the angles the cells make to the holes or posts) and is thought to be due to the fact that the cells use the posts as anchorage points to hold themselves to the surface. It is also shown that cells preferentially align with the structures depending on the dimensions of the structures and the distance between neighboring structures. This is important when designing structured surfaces for cellsurface interaction studies for materials to be used in, for example, drug delivery or tissue engineering.

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“…Biocompatibility refers to the reaction elicited by a material when it is inserted into the body; ideally, this reaction should be favorable and should not provoke a negative response such as an attack by the immune system on the foreign material [27][28][29][30]. Surface modification techniques strive to retain favorable bulk properties while changing the surface to cater to specific needs, often to enhance biocompatibility [16,31].…”

Section: Surface Modification To Increase Biocompatibilitymentioning

confidence: 99%

“…Plasma processing alters the surface topography through melting and recrystallization processes, resulting in more ridges compared to the original surface, as displayed in Figure 2 [30,45]. Etching and sanding, both plasma-or chemical-based, as well as polishing and/or microblasting also serve to improve surface roughness [1,46].…”

Section: Surface Rougheningmentioning

confidence: 99%

A Survey of Surface Modification Techniques for Next-Generation Shape Memory Polymer Stent Devices

Govindarajan

Shandas

2014

Polymers

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Abstract:The search for a single material with ideal surface properties and necessary mechanical properties is on-going, especially with regard to cardiovascular stent materials. Since the majority of stent problems arise from surface issues rather than bulk material deficiencies, surface optimization of a material that already contains the necessary bulk properties is an active area of research. Polymers can be surface-modified using a variety of methods to increase hemocompatibilty by reducing either late-stage restenosis or acute thrombogenicity, or both. These modification methods can be extended to shape memory polymers (SMPs), in an effort to make these materials more surface compatible, based on the application. This review focuses on the role of surface modification of materials, mainly polymers, to improve the hemocompatibility of stent materials; additional discussion of other materials commonly used in stents is also provided. Although shape memory polymers are not yet extensively used for stents, they offer numerous benefits that may make them good candidates for next-generation stents. Surface modification techniques discussed here include roughening, patterning, chemical modification, and surface modification for biomolecule and drug delivery.

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Chemical and topographical patterning for directed cell attachment

Cited by 215 publications

References 63 publications

Biology on a Chip: Microfabrication for Studying the Behavior of Cultured Cells

Biology on a Chip: Microfabrication for Studying the Behavior of Cultured Cells

Directional Alignment of MG63 Cells on Polymer Surfaces Containing Point Microstructures

A Survey of Surface Modification Techniques for Next-Generation Shape Memory Polymer Stent Devices

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