Chemical and Topographical Modification of Polycarbonate Surfaces through Diffusion/Photocuring Processes of Hydrogel Precursors Based on Vinylpyrrolidone

Gallardo, Alberto; Luján, Noelia; Reinecke, Helmut; García, Carlos Tejerizo; Campo, Ángel Adolfo del; Rodríguez‐Hernández, Juan

doi:10.1021/acs.langmuir.6b04143

Cited by 6 publications

(11 citation statements)

References 24 publications

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“…Hydrogels were synthesized by conventional radical photopolymerization using the experimental protocol described in reference. 30 The time elapsed between the initial contact between the monomer mixture and PC support and the UV irradiation of exposure to monomer mixture was varied between 0 and 20 min. As will be described later, this parameter affects the wrinkle characteristics (period and amplitude).…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…For further details about these formulations the reader is referred to the previous contribution. 30 Protocol for the Functionalized Wrinkles. The ionic nature of the hydrogel wrinkles (negative, positive, stoichiometric mixture of both charges) could be easily modified by the proper addition of M-SO 3 − and/or M-N + to the photocurable formulation.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…The chemical composition and depth profiles of the polymeric films were obtained using CRM-Alpha 300 RA microscope (WITec, Ulm, Germany). A general description of this equipment is provided in ref 30.…”

Section: Characterization Of the Wrinkled Surfaces The Zeta-20 Truementioning

confidence: 99%

“…Within this context, we described a procedure to simultaneously wrinkle and coat polycarbonate supports (PC) with anionic vinylpyrrolidone-based hydrogels . It is worth mentioning that simultaneous surface hydrophilization and structuration of thermoplastic supports has great interest in biomedicine, among other fields, because those processes may adapt the surface to specific bioneeds without altering the mechanical block properties. − , For this purpose, a photosensitive mixture was placed on top of a thermoplastic and photopolymerized thus leading to the formation of the hydrogel on top of a thermoplastic polymer.…”

Section: Introductionmentioning

confidence: 99%

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Wrinkled Hydrogel Surfaces with Modulated Surface Chemistry and Topography: Evaluation As Supports for Cell Growth and Transplant

Martínez-Campos

Gallardo

Luján

et al. 2019

ACS Appl. Bio Mater.

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We report a straightforward procedure to simultaneously functionalize hydrophobic PC supports with vinylpyrrolidone (VP)-based hydrogels with both variable ionic load as well as surface topography, forming wrinkles. The strategy involves three consecutive steps: first, a contact of the polymeric support (PC) with a photopolymerizable solution comprising vinylic monomers is established. Second, UV-light exposure curing of the solution and finally, the third step involes the swelling of the hydrogel network that finally provokes its surface detachment. Interestingly, a wrinkled hybrid PC/hydrogel interface remains after this detachment. Several experimental parameters permitted us to finely control the wrinkle characteristics such as amplitude and period. The experimental parameters that can be varied, herein we will focus on the variation of the elapsed time (i.e., time of contact between the support and the photosensitive monomer mixture, or the solvent (type and amount) included in the monomer mixture. Equally, the nature of the additional ionic methacrylate monomers (M) employed plays a key role on the final topography. According to confocal raman microscopy results, we evidenced that a monomer diffusion into the PC substrate before the UV irradiation step modifies the interfacial (hydrogel/substrate) chemical composition and leads upon UV irradiation to the formation of a thin hydrogel surface layer. The surface chemical composition and structural characteristics were demonstrated to significantly change the surface interaction with different cell lines, affecting cell adhesion, proliferation, or transplantation.

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Section: ■ Experimental Sectionmentioning

confidence: 99%

Section: ■ Experimental Sectionmentioning

confidence: 99%

Section: Characterization Of the Wrinkled Surfaces The Zeta-20 Truementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Wrinkled Hydrogel Surfaces with Modulated Surface Chemistry and Topography: Evaluation As Supports for Cell Growth and Transplant

Martínez-Campos

Gallardo

Luján

et al. 2019

ACS Appl. Bio Mater.

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“…However, these methods suffer from complicated manufacturing process and specific material modeling, which have been demonstrated to restrict the large‐area fabrication and thus limit their practical applications. With the increasing interest in properties associated with complex structured surfaces, a simple and scalable method is intriguing and urgent to be developed in order to fabricate various desired structured hydrogel surfaces …”

mentioning

confidence: 99%

Diffusion–Freezing‐Induced Microphase Separation for Constructing Large‐Area Multiscale Structures on Hydrogel Surfaces

Lei

Rong

et al. 2019

Advanced Materials

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and, in particular, micro/nanostructure on their surfaces plays an important role in numerous natural systems. [7][8][9][10] For example, carp, filefish, and seaweed can keep themselves clean in oil-polluted water because of the existence of micro/ nanohierarchical structured hydrogel material on their surface. [11,12] The wharf roach (Ligia exotica) and pitcher plant harness their surface microscaled morphologies to control liquid transportation for survival. [13,14] Inspired by the nature biological material, constructing structured functional surface of hydrogel-based materials has become one of the most promising solutions for the researchers to satisfy the increasing need of novel functional materials. Current fabrication strategies mainly focus on surface chemical modifications, [15][16][17] template replica, [18][19][20][21] photolithography, [22] laser scanning, [23] and 3D printing. [24] However, these methods suffer from complicated manufacturing process and specific material modeling, which have been demonstrated to restrict the large-area fabrication and thus limit their practical applications. With the increasing interest in properties associated with complex structured surfaces, a simple and scalable method is intriguing and urgent to be developed in order to fabricate various desired structured hydrogel surfaces. [25][26][27] Here, we report a general strategy for constructing microand nanostructured hydrogel surfaces in the miscible polymer diffusion layer directly during the process of gel formation. This strategy relies on the interplay between polymer chain diffusion and the subsequent freezing-induced gelation and microphase separation processes. The proposed method exploits the interface of two miscible polymers, one of which needs to undergo gelation. Our strategy is accomplished through two successive processes, i.e., the diffusion-driven mixing process followed by the freezing-induced gelation and microphase separation. The former forms a diffusion layer, while the latter produces structures in this diffusion layer. The gelation couples to the microphase separation and they finally determine the micro/ nanostructures on the gel surfaces. Meanwhile, the hydrogel surfaces with the gradient structure and patterned surfaces can also be regulated through the control of gelation temperature and diffusion areas. Moreover, the micro/nanocomposite Hydrogels with multiscale structured surface have attracted significant attention for their valuable applications in diverse areas. However, current strategies for the design and fabrication of structured hydrogel surfaces, which suffer from complicated manufacturing processes and specific material modeling, are not efficient to produce structured hydrogel surfaces in large area, and therefore restrict their practical applications. To address this problem, a general and reliable method is reported, which relies on the interplay between polymer chain diffusion and the subsequent freezing-induced gelation and microphase separation processes. The basic idea ...

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Wrinkled Interfaces: Taking Advantage of Anisotropic Wrinkling to Periodically Pattern Polymer Surfaces

et al. 2023

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Periodically patterned surfaces can cause special surface properties and are employed as functional building blocks in many devices, yet remaining challenges in fabrication. Advancements in fabricating structured polymer surfaces for obtaining periodic patterns are accomplished by adopting "top-down" strategies based on self-assembly or physico-chemical growth of atoms, molecules, or particles or "bottom-up" strategies ranging from traditional micromolding (embossing) or micro/nanoimprinting to novel laser-induced periodic surface structure, soft lithography, or direct laser interference patterning among others. Thus, technological advances directly promote higher resolution capabilities. Contrasted with the above techniques requiring highly sophisticated tools, surface instabilities taking advantage of the intrinsic properties of polymers induce surface wrinkling in order to fabricate periodically oriented wrinkled patterns. Such abundant and elaborate patterns are obtained as a result of self-organizing processes that are rather difficult if not impossible to fabricate through conventional patterning techniques. Focusing on oriented wrinkles, this review thoroughly describes the formation mechanisms and fabrication approaches for oriented wrinkles, as well as their fine-tuning in the wavelength, amplitude, and orientation control. Finally, the major applications in which oriented wrinkled interfaces are already in use or may be prospective in the near future are overviewed.

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Chemical and Topographical Modification of Polycarbonate Surfaces through Diffusion/Photocuring Processes of Hydrogel Precursors Based on Vinylpyrrolidone

Cited by 6 publications

References 24 publications

Wrinkled Hydrogel Surfaces with Modulated Surface Chemistry and Topography: Evaluation As Supports for Cell Growth and Transplant

Wrinkled Hydrogel Surfaces with Modulated Surface Chemistry and Topography: Evaluation As Supports for Cell Growth and Transplant

Diffusion–Freezing‐Induced Microphase Separation for Constructing Large‐Area Multiscale Structures on Hydrogel Surfaces

Wrinkled Interfaces: Taking Advantage of Anisotropic Wrinkling to Periodically Pattern Polymer Surfaces

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