Chemical and topographical analyses of dentine surfaces after Carisolv™ treatment

Arvidsson, Anna; Liedberg, Bo; Möller, Kenneth; Lyvén, Benny; Sellén, Annika; Wennerberg, Ann

doi:10.1016/s0300-5712(01)00051-3

Cited by 37 publications

(34 citation statements)

References 13 publications

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“…13 For reliable surface characterization, parameters describing surface variation in the spatial direction are also needed. 36 Thus, three-dimensional assessment of surface topography is becoming more widely appreciated. AFM three-dimensional images (Figure 2) showed that the nanoscale agglomerates were large when the NaOH concentration was low.…”

Section: Discussionmentioning

confidence: 99%

Osteogenic activity of titanium surfaces with nanonetwork structures

Huan¹,

Komasa²,

Taguchi³

et al. 2014

IJN

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Background Titanium surfaces play an important role in affecting osseointegration of dental implants. Previous studies have shown that the titania nanotube promotes osseointegration by enhancing osteogenic differentiation. Only relatively recently have the effects of titanium surfaces with other nanostructures on osteogenic differentiation been investigated. Methods In this study, we used NaOH solutions with concentrations of 2.5, 5.0, 7.5, 10.0, and 12.5 M to develop a simple and useful titanium surface modification that introduces the nanonetwork structures with titania nanosheet (TNS) nanofeatures to the surface of titanium disks. The effects of such a modified nanonetwork structure, with different alkaline concentrations on the osteogenic differentiation of rat bone marrow mesenchymal stem cells (BMMSCs), were evaluated. Results The nanonetwork structures with TNS nanofeatures induced by alkali etching markedly enhanced BMMSC functions of cell adhesion and osteogenesis-related gene expression, and other cell behaviors such as proliferation, alkaline phosphatase activity, extracellular matrix deposition, and mineralization were also significantly increased. These effects were most pronounced when the concentration of NaOH was 10.0 M. Conclusion The results suggest that nanonetwork structures with TNS nanofeatures improved BMMSC proliferation and induced BMMSC osteogenic differentiation. In addition, the surfaces formed with 10.0 M NaOH suggest the potential to improve the clinical performance of dental implants.

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Section: Discussionmentioning

confidence: 99%

Osteogenic activity of titanium surfaces with nanonetwork structures

Huan¹,

Komasa²,

Taguchi³

et al. 2014

IJN

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show abstract

“…In addition, several articles have shown that Carisolv™ can be used effectively in carious dentin (9,30,38), which was not observed in the present work. As this product acts on carious dentin preserving the healthy structure, it may be assumed that the results of this research were not in favor of this substance due to use of healthy dentine, in which only collagen derangement was promoted in vitro.…”

Section: Discussioncontrasting

confidence: 78%

“…Carisolv™ has been widely used in the treatment of carious lesions (9). It comprises a mixture of sodium hypochlorite 0.5% and three amino acids (Lysine, Leucine and Glutamic acid) in a gel preparation.…”

Section: Introductionmentioning

confidence: 99%

The role of Carisolv™ and different auxiliary chemical substances in the removal of bovine root canal smear layer

et al. 2006

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To evaluate the effectiveness of Carisolv™and different auxiliary chemical substances in root canal smear layer (SL) removal. SL was produced in the centre of 40 hemi-disks of bovine root dentine. The samples were divided into four irrigation groups (G): GI (control) -0.9% NaCl; GII -1% NaOCl + 0.9% NaCl; GIII -Carisolv™ + 0.9% NaCl; GIV -1% NaOCl + 10% citric acid solution + 0.9% NaCl. The photomicrographs (SEM analysis) were coded (0 -absence of SL; 1 -moderate SL; 2 -dense SL with visible tubules; 3 -dense SL with no visible tubules). GIV was more effective in SL removal (P < 0.01). It should be noted that GI and GIII obtained score 3 in 100% of the samples (P > 0.01). Conclusion: NaOHCl, citric acid and NaCl solutions, when used together, presented a better performance in the removal of SL when compared to the other solutions. (J. Oral Sci. 48, [99][100][101][102][103] 2006)

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“…Many studies have reported that Carisolv gel has no adverse effect on the mineral content of dentine. [35][36][37] Sakoolnamarka et al 38 and Hamama et al 39 reported that the Ca:P ratio of residual dentine following Carisolv removal of carious dentine did not significantly differ from the Ca:P ratio of sound dentine. This may imply that Carisolv is an effective method of removing caries-infected dentine.…”

Section: Carisolv Instrumentsmentioning

confidence: 99%

“…This may imply that Carisolv is an effective method of removing caries-infected dentine. 25,36,40,41 Scanning electron microscope observations of the dentine surface following Carisolv treatment showed that the excavated surface has an irregular surface topography and was also partially covered with a smear layer. 39,[41][42][43][44][45] The majority of studies have reported that the hardness of residual dentine following Carisolv treatment was lower than the hardness of residual dentine following conventional caries removal methods.…”

Section: Carisolv Instrumentsmentioning

confidence: 99%

Current update of chemomechanical caries removal methods

2014

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Chemomechanical caries removal is an excellent method for minimally invasive caries excavation, and the removal agents are either sodium hypochlorite (NaOCl)-or enzyme-based. The NaOCl-based agents include GK-101, GK-101E (Caridex) and Carisolv, and the enzyme-based agents include Papacarie and the experimental material, Biosolv. This review outlines the changes in chemomechanical caries removal methods and focuses on recently published laboratory and clinical studies. The historical development, mechanism of action, excavation time and biological effects on pulp and dental hard tissues are described. Based on existing evidence, the currently available chemomechanical caries removal methods are viable alternatives to conventional rotary instrument methods. Chemomechanical methods could be extremely useful in very anxious, disabled and paediatric patients. It does seem some of these agents would still benefit from quicker excavation times in order to achieve more universal acceptance. However, as a means of conserving the caries-affected dentine, chemomechanical caries removal is possibly much more successful than conventional rotary instrumentation.Keywords: Biosolv, Caridex, Carisolv, chemomechanical caries removal, minimal intervention dentistry, Papacarie.Abbreviations and acronyms: EDTA = ethylene diamine tetra-acetic acid; FDA = US Food and Drug Administration; NaOC1 = sodium hypochlorite; VAV = Visual Analogue and Verbal scale; WBFP = Wong Baker Faces Pain scale.

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Chemical and topographical analyses of dentine surfaces after Carisolv™ treatment

Cited by 37 publications

References 13 publications

Osteogenic activity of titanium surfaces with nanonetwork structures

Osteogenic activity of titanium surfaces with nanonetwork structures

The role of Carisolv™ and different auxiliary chemical substances in the removal of bovine root canal smear layer

Current update of chemomechanical caries removal methods

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