Chemical and structural characterization of the mineral phase from cortical and trabecular bone

Bigi, Adriana; Cojazzi, Gianna; Panzavolta, Silvia; Ripamonti, A.; Roveri, Norberto; Romanello, Milena; Noris-Suárez, Karem; Moro, Luigi

doi:10.1016/s0162-0134(97)00007-x

Cited by 244 publications

(150 citation statements)

References 29 publications

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“…CAP, (Ca 10−x ,Na x )(PO 4 ) 6−x (CO 3 ) x (OH) 2 , and HAP, Ca 10 (PO 4 ) 6 (OH) 2 , were prepared by direct precipitation from solution using methods described by LeGeros (see Ref. 5, pp 22-24).…”

Section: Experimental Methodsmentioning

confidence: 99%

“…Based on X-ray diffraction, infrared spectroscopy, and chemical analysis, calcium hydroxyapatite (HAP), Ca 10 (PO 4 ) 6 (OH) 2 , is often regarded as the principal inorganic constituent of bone mineral. [1][2][3] Thus HAP and its derivatives have been used extensively in in vitro studies to investigate the complex nature of skeletal mineral scaffolding.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Thus HAP and its derivatives have been used extensively in in vitro studies to investigate the complex nature of skeletal mineral scaffolding. However, this ignores the role of minor components (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Bisphosphonate binding affinity as assessed by inhibition of carbonated apatite dissolution in vitro

Henneman

Nancollas

Ebetino

et al. 2007

J Biomedical Materials Res

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Bisphosphonates (BPs), which display a high affinity for calcium phosphate surfaces, are able to selectively target bone mineral, where they are potent inhibitors of osteoclast-mediated bone resorption. The dissolution of synthetic hydroxyapatite (HAP) has been used previously as a model for BP effects on natural bone mineral. The present work examines the influence of BPs on carbonated apatite (CAP), which mimics natural bone more closely than does HAP. Constant composition dissolution experiments were performed at pH 5.50, physiological ionic strength (0.15M) and temperature (37°C). Selected BPs were added at (0.5 × 10 −6 ) to (50.0 × 10 −6 )M, and adsorption affinity constants, K L , were calculated from the kinetics data. The BPs showed concentrationdependent inhibition of CAP dissolution, with significant differences in rank order zoledronate > alendronate > risedronate. In contrast, for HAP dissolution at pH 5.50, the differences between the individual BPs were considerably smaller. The extent of CAP dissolution was also dependent on the relative undersaturation, σ, and CAP dissolution rates increased with increasing carbonate content. These results demonstrate the importance of the presence of carbonate in mediating the dissolution of CAP, and the possible involvement of bone mineral carbonate in observed differences in bone affinities of BPs in clinical use.

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Section: Experimental Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bisphosphonate binding affinity as assessed by inhibition of carbonated apatite dissolution in vitro

Henneman

Nancollas

Ebetino

et al. 2007

J Biomedical Materials Res

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show abstract

“…Figure 3 shows the FT-IR spectra of the SiO 2 macrospheres after aged under different conditions and those of HAp-SiO 2 ones, where the bands have been assigned according to the literatures. 37 Journal of the Ceramic Society of Japan 120 [9] 355-361 2012 JCS-Japan energy region were assigned to¯1(SiO 4 ) and ¤(SiO). The¯1 mode of the SiO 4 tetrahedron, belonging to representation A 1 , is only Raman active, but sometimes the ³800 cm ¹1 IR band has been assigned to this mode.…”

Section: Macrospheresmentioning

confidence: 99%

Sol–gel preparation of apatite-coated silica macrospheres from water glass and their adsorption of bovine serum albumin and lysozyme

Shirosaki

Hayakawa

et al. 2012

J. Ceram. Soc. Japan

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Silica gel macrospheres were prepared from water glass as the silica source. The water glass solution was mixed with sodium alginate solution and added dropwisely to 1 M CaCl 2 solution to form macrospheres with ³4 and 2.6 mm in diameter. Those SiO 2 macrospheres were soaked in 1:1 (volume) mixture of ethanol and 0.1 M Na 2 HPO 4 to deposit hydroxyapatite layer (HAp-SiO 2 macrospheres). Bovine serum albumin (BSA) and egg lysozyme (LYZ) were adsorbed those SiO 2 and HAp-SiO 2 macrospheres. The amount of proteins adsorbed was well correlated to the Langmuir-type adsorption equation. The electrostatic interaction was predominant between the macrosphere surface and the protein molecules. Protein molecular entrapment in the mesopores (5 25 nm) was also probable for the SiO 2 macrospheres but not applicable to the HAp-SiO 2 ones without the mesopores. From consideration that protein molecule has a few groups with negative or positive partial charges, a multi-layer adsorption model was proposed.

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“…According to studies of biological apatite, bone apatite is not pure hydroxyapatite (HAp) but contains about 3-8 wt% carbonate ions (CO 3 2− ) [1][2][3] , hence should be rightfully called carbonate apatite (CO3Ap). Furthermore, osteoclasts have been shown to resorb CO3Ap and then osteoblasts form new bone based on process similar to bone remodeling 4,5) .…”

Section: Introductionmentioning

confidence: 99%

Influence of PLGA concentrations on structural and mechanical properties of carbonate apatite foam

Munar

Tsuru

et al. 2013

Dent. Mater. J.

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Reinforcement with bioresorbable polymer such as PLGA is one of the useful ways to improve the mechanical property of brittle carbonate apatite (CO 3 Ap) foam. In the present study, CO 3 Ap foam was reinforced with various concentrations of PLGA solution (5, 10, 15 and 20 wt%) using vacuum infiltration method and its influence on structure, porosity and mechanical property was investigated. It was found that the amount of PLGA inside the hollow space of the CO 3 Ap foam strut increased with the concentration of PLGA. Porosity likewise was significantly (p<0.05) reduced from 94% (CO 3 Ap foam without PLGA) down to 82% (CO 3 Ap foam reinforced with 20 wt% PLGA). Compressive strength of CO 3 Ap foam significantly (p<0.05) increased from 0.02 MPa (CO 3 Ap foam without PLGA) up to 1.5 MPa (CO 3 Ap foam reinforced with 20 wt% PLGA).

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Chemical and structural characterization of the mineral phase from cortical and trabecular bone

Cited by 244 publications

References 29 publications

Bisphosphonate binding affinity as assessed by inhibition of carbonated apatite dissolution in vitro

Bisphosphonate binding affinity as assessed by inhibition of carbonated apatite dissolution in vitro

Sol–gel preparation of apatite-coated silica macrospheres from water glass and their adsorption of bovine serum albumin and lysozyme

Influence of PLGA concentrations on structural and mechanical properties of carbonate apatite foam

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