Chemical and radiochemical evaluation of the purity of99mTc extracted by MEK

Narasimhan, D.; Mani, R. S.

doi:10.1007/bf02519685

Cited by 13 publications

(9 citation statements)

References 2 publications

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“…Such low specific activity 99 Mo/ 99m Tc preparations require separation technologies different from the current commercial alumina columns as alumina has a capacity of only up to 20 mg/g molybdenum. Alternative technologies for separation, including solvent extraction, have been variously reviewed in literature [15][16][17][18][19][20][21][22]. MEK solvent extraction was described first by Gerlit in 1956 [23].…”

Section: Resultsmentioning

confidence: 99%

Processing and evaluation of linear accelerator-produced 99Mo/99mTc in Canada

Mangera

Ogbomo

Zriba

et al. 2015

J Radioanal Nucl Chem

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We are developing electron linear accelerator 100 Mo(c,n) 99 Mo technology as a replacement to nuclear reactor 235 U(n,f) 99 Mo production. We report irradiation of natural molybdenum disks (25 MeV, 10 kW) and 100 Moenriched disks (35 MeV, 2 kW), their dissolution and the extraction of 99m Tc-pertechnetate. Up to 6.2 GBq 99 Mo was produced, solvent extraction was performed at [90 % yields of 99m Tc, and quality control showed that a product with high radionuclidic and radiochemical purity could be obtained. Irradiated natural molybdenum products showed more impurities ( 91m Nb, 92m Nb, 95m Nb and 95 Nb) than enriched target material. Linear accelerator technology is feasible for production of quality 99 Mo/ 99m Tc, particularly when paired with 100 Mo-enriched targets.

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Section: Resultsmentioning

confidence: 99%

Processing and evaluation of linear accelerator-produced 99Mo/99mTc in Canada

Mangera

Ogbomo

Zriba

et al. 2015

J Radioanal Nucl Chem

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“…Counter to these obvious advantages, MANI and his co-workers [7] identified in MEK-derived " m Tc the presence of condensation products which were capable of distorting biological activity. These investigators suggested passing the MEK-" m Tc stream through an alumina column, before evaporation, as a means of avoiding the detrimental effects of organic impurities.…”

Section: The Solvent (Mek) Extraction Generatormentioning

confidence: 98%

Technetium Generators: Status and Prospects

Boyd

1987

Radiochimica Acta

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The technetium-99m generator has experienced many improvements and changes since it was introduced to nuclear medicine in the late 1950 s. In the industrialized countries of the world, the. most common form in use today is the chromatographic generator, based on fission molybdenum-99. This presents significant problems to the less industrialized countries and to overcome these much research is under way searching for viable alternatives. Improvements have been made to techniques for generating technetium-99m by MEK extraction and sublimation. A new technology, based on the separation of technetium-99m from an insoluble gel containing (η,γ) molybdenum-99, introduces exciting prospects which promise all the advantages currently enjoyed only by the fission-molybdenum-99 generator without any of the concomitant problems of complex processing, pollution and the need to dispose of high activity wastes. The paper addresses a number of these developments which are seen as signposts to the future.

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“…On the other hand, surprisingly the MEK is sometimes kept in contact with the aqueous phase between extractions [14]. It has been reported that the MEK impurities do not alter the yield, and that they can be eliminated by filtration on alumina prior to evaporation of the solvent, or by adjustment of the pH of the final product followed by membrane filtration [8].…”

Section: C) Extractionmentioning

confidence: 99%

“…The separation of Tc from Mo in a strongly basic solution was reported by Gerlit at the first Geneva Conference in 1955 [6]. During the following years, the influence of potassium hydroxide, potassium carbonate and molybdate at various concentrations on the separation was studied in detail [7,8]. It was found that for high molybdate concentrations ( > 100g/l) and high alcaline hydroxide or carbonate concentrations (> 4N), the distribution coefficient of Tc between MEK and the aqueous phase was frequently higher than 100, while that of Mo remained below 0.1.…”

Section: Introductionmentioning

confidence: 99%

“…According to GERLIT [6], the distribution coefficient of Mo for trace amounts of the element increases from 5 χ IO -4 in a neutral solution to 0.2 in 5 Ν NaOH. Other groups, however, have observed only negligible changes of K Mo with the concentration of Mo and of other salting-out reagents [7,8]. (7), » -KOH only [7], η -NaOH only [6] Initially, the MEK extraction was used as a further purification step of 99m Tc in connection with the first generation of separation columns, which yielded a product which was dilute and of insufficient purity.…”

Section: Introductionmentioning

confidence: 99%

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