Chemical and postural influence on scalene and diaphragmatic activation in humans

Xie, Ailiang; Takasaki, Yoshito; Popkin, J.; Orr, David W.; Bradley, T. Douglas

doi:10.1152/jappl.1991.70.2.658

Cited by 14 publications

(12 citation statements)

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“…Since the rate of CO2 elimination is directly proportional to 14, it seems appropriate that 1I would be maintained in the face of rising P., co regardless of body position. Our data and that from other investigators (Rigg et al 1974;Grassino, Derenne, Almirall, Milic-Emili & Whitelaw, 1981;Chapman & Rebuck, 1984a;Xie et al 1991) are consistent in this regard. In the present study, however, it was demonstrated that higher peak APOeS I was developed in order to maintain the same VT and P4 in the supine as in the upright position.…”

Section: Subjectssupporting

confidence: 92%

“…However, the effects of body position on the ventilatory response to hypoxia have not been well characterized. In preliminary studies for previous investigations from our laboratory (Takasaki, Orr, Popkin, Xie & Bradley, 1989;Xie et al 1991) it was observed that the slope of the ventilatory response to hypoxia was lower in supine than upright human subjects. It therefore seemed possible that under hypoxic conditions, other respiratory output variables, such as respiratory force generation, might bear a more consistent relationship to oxyhaemoglobin saturation (Sa,2).…”

Section: Introductionmentioning

confidence: 87%

“…We (Xie, Takasaki, Popkin, Orr & Bradley, 1991) and others (Rigg, Rebuck & Campbell, 1974;Weissman, Abraham, Askanazi, Milic-Emili, Hyman & Kinney, 1982;Chapman & Rebuck, 1984a) have shown that the ventilatory response to hyperoxic, progressive hypercapnic rebreathing (HCVR) was similar in the upright seated and supine positions despite alterations in respiratory system mechanics (Attinger, Monroe & Segal, 1954; Granath, Horie & Linderholm, 1959;Wiley & Zechman, 1966;Milic-Emili & Zin, 1986;Duggan, Watson & Pride, 1990). However, the effects of body position on the ventilatory response to hypoxia have not been well characterized.…”

Section: Introductionmentioning

confidence: 96%

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Influence of body position on pressure and airflow generation during hypoxia and hypercapnia in man.

Xie¹,

Takasaki²,

Popkin³

et al. 1993

The Journal of Physiology

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SUMMARY1. Inspiratory oesophageal pressure and ventilatory responses to hyperoxic, progressive hypercapnic rebreathing (HCVR) and isocapnic, progressive hypoxic rebreathing (HVR) were studied in five normal males in both supine and upright seated positions.2. No significant differences were found in the ventilatory response to hypercapnia between the supine and upright position. The slopes of the relationship between minute ventilation (VI) and the increase of end tidal Pco2 (APET, C02) were 3-27+0-23 and 2-76 + 024 1 min-mmHg-' supine and upright, respectively. However, the change in oesophageal pressure from the end expiratory level observed during quiet breathing to that at peak inspiration (AP.,es I) in relationship to APETCO2 was greater supine than upright (1-23+0 07 versus 0 79+0411 cmH20 mmHg-', P < 0-01).3. In contrast, during hypoxia-stimulated breathing the slope of the minute ventilation versus oxyhaemoglobin saturation curve (VI-Sa, 2) was flatter supine than upright (1P00+0-03 versus 175+0-05 1 min-(percentage fall in Sa, o2)1 P < 0-0001), but ApoI I in relation to Sa°2 during hypoxic rebreathing was similar supine and upright (0-38 + 0-03 versus 0 40 + 0-04 cmH2O (percentage fall in Sa' 02)' respectively).

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Section: Subjectssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 96%

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Influence of body position on pressure and airflow generation during hypoxia and hypercapnia in man.

Xie¹,

Takasaki²,

Popkin³

et al. 1993

The Journal of Physiology

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“…The ventilatory responses to hypoxia and hypercapnia were measured in normal subjects in the upright, sitting, and supine positions. Most studies have reported a substantial reduction in the hypoxic ventilatory response in the supine position compared with that in the upright position in humans [2-5]. It has also been suggested that the ventilatory response to CO 2 is not influenced by changes in posture.…”

Section: Introductionmentioning

confidence: 99%

Effects of body position on the ventilatory response to hypercapnia

Donina

Aleksandrova

2009

Eur J Med Res

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Effect of posture on the hypercapnic ventilatory response was studied on the anaesthetized rats by using rebreathing techniques in the supine and head-down positions. There were no statistically significant alterations in tidal volume, frequency, minute ventilation, and PETCO2 between the head-down and supine positions during breathing at rest. However, the esophageal pressure inspiratory swings were significantly greater in the head-down compared with supine position. Moreover, we found that body position did not affect the hypercapnic ventilatory response, but did affect the relationship between inspiratory driving pressure and the increase of end tidal PCO2. Greater inspiratory pressure is required to maintain the same level of the ventilatory response to hypercapnia in the horizontal position with the head-down. We believe that the discrepancy between postural alterations in the hypercapnic ventilatory and pressure responses is presumably a result of decreased lung compliance and increased airflow impedance of respiratory system in the head-down position.

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“…This limited chest wall expansion puts greater demand on primary and accessory muscles [45]. Therefore, there is Fig.…”

Section: Discussionmentioning

confidence: 99%

Assessment of muscle shortening and static posture in children with persistent asthma

et al. 2006

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Asthmatic patients experience an increase in airway resistance that overburdens both respiratory and non-respiratory muscles. The objective of the present study was to determine whether children with persistent asthma present muscle shortening and postural changes. The 60 boys evaluated, aged 7-12 (pubertal ages up to Tanner stage G2) were divided into three age- and BMI-matched groups of equal number: CON (no history of asthma or allergy); MPA (mild persistent asthma); SPA (severe persistent asthma). Pulmonary function, muscle shortening and static posture were evaluated. The SPA group presented higher protraction of the head and shoulder compared with the CON group [9.5 (6.0-12.0) degrees vs 5.5 (0.0-12.0) degrees, P < 0.05; 0.89 (0.80-0.94) anterior/posterior ratio vs 0.94 (0.87-1.1) anterior/posterior ratio, P < 0.01)]. Severe asthmatic patients also presented shortening of arm flexor and posterior muscle of the thigh compared with the CON group [18.0 (10.0-24.0) degrees vs 12.0 (6.0-16.0) degrees, P < 0.05; and 16.5 (10.0-38.5) cm vs 8.0 (0.0-21.0) cm, respectively, P < 0.05]. Chest expansion at axillar and xiphoid levels were limited in SPA subjects compared with CON subjects [3.7 (1.5-6.5) cm vs 5.5 (2.0-8.0) cm and 4.7 (1.5-6.5) vs 6.0 (3.5-8.0) cm, respectively, P < 0.01]. SPA subjects also presented a higher incidence of lumbar spine straightening compared with CON and MPA subjects. Moderate asthmatic subjects presented intermediate values compared with severe and control subjects in five out nine evaluated outcomes. Our data suggest that severe asthmatic children present postural adaptations and muscle shortening that seem to be related to disease severity.

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Chemical and postural influence on scalene and diaphragmatic activation in humans

Cited by 14 publications

References 0 publications

Influence of body position on pressure and airflow generation during hypoxia and hypercapnia in man.

Influence of body position on pressure and airflow generation during hypoxia and hypercapnia in man.

Effects of body position on the ventilatory response to hypercapnia

Assessment of muscle shortening and static posture in children with persistent asthma

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