Chemical and physico‐chemical alterations of human erythrocytes by periodate, succinic anhydride, 2‐phenylethanol, and 1,1‐dimethylphenylethanol: effects on membrane permeability and on metabolism of intact cells and hemolysates

Brossmer, Reinhard; Bohn, B.

doi:10.1016/0014-5793(74)80293-0

FEBS Letters

1974

DOI: 10.1016/0014-5793(74)80293-0

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Chemical and physico‐chemical alterations of human erythrocytes by periodate, succinic anhydride, 2‐phenylethanol, and 1,1‐dimethylphenylethanol: effects on membrane permeability and on metabolism of intact cells and hemolysates

Reinhard Brossmer

B. Bohn

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1974

1991

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Cited by 6 publications

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Selective erythrocyte potassium efflux following pulse treatment with tellurite

Kurantsin‐Mills

1991

J. Biochem. Toxicol.

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Human erythrocytes exposed to 0.1 mM tellurite (K2TeO3) in an isotonic buffered choline chloride medium for 15 min at 37 degrees C, washed, and incubated further in the absence of the chemical in the buffer, exhibited selective leakiness for potassium within minutes. The potassium efflux curve was sigmoidal, with an initially slow leakage followed by a sharp rise (first-order kinetics) and a plateau by 60 min. After 15 min, 30-50% of the total potassium concentration had leaked from the cells, although less than 1% lysis had occurred. The control cells incubated in buffer with no K2TeO3 exhibited no potassium leakage. The mean volume of the K2TeO3-treated erythrocytes increased and their median density decreased, indicating changes in the colloid osmotic state and physical characteristics of the cells. However, cells pretreated with K2TeO3 exhibited no significant change in glutathione (GSH) concentration and no membrane lipid peroxidation, unlike cells pretreated with t-butylhydroperoxide (Deuticke et al., Biochim. Bio phys. Acta, 899, 125-128, 1987). The enhanced potassium permeability of the K2TeO3-treated erythrocytes preceded the increase in cell volume, intracellular hydration, and a decrease in median density. We suggest that perturbation of the lipid-protein interaction in the membrane by the oxidant alters the potassium permeability and results in the selective leakage with eventual hemolysis.

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Selective erythrocyte potassium efflux following pulse treatment with tellurite

Kurantsin‐Mills

1991

J. Biochem. Toxicol.

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Oxidative stress of human erythrocytes by iodate and periodate Reversible formation of aqueous membrane pores due to SH-group oxidation

Heller

Poser

Haest

et al. 1984

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Studies on the mechanism of action of miconazole—II. Interaction of miconazole with mammalian erythrocytes

Swamy

Sirsi

Rao

1976

Biochemical Pharmacology

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Chemical and physico‐chemical alterations of human erythrocytes by periodate, succinic anhydride, 2‐phenylethanol, and 1,1‐dimethylphenylethanol: effects on membrane permeability and on metabolism of intact cells and hemolysates

Cited by 6 publications

References 4 publications

Selective erythrocyte potassium efflux following pulse treatment with tellurite

Selective erythrocyte potassium efflux following pulse treatment with tellurite

Oxidative stress of human erythrocytes by iodate and periodate Reversible formation of aqueous membrane pores due to SH-group oxidation

Studies on the mechanism of action of miconazole—II. Interaction of miconazole with mammalian erythrocytes

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