Chemical and physical properties of a hydrogel wound dressing

Kickhöfen, B.; Wokalek, H.; Scheel, Doris; Ruh, Helga

doi:10.1016/0142-9612(86)90092-x

Cited by 67 publications

(29 citation statements)

References 5 publications

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“…On the other hand, the dressing is more beneficial to wounds with moderate exudates than for dry wounds because of large water loss (48-70%) when exposed to air with a relative humidity of 40% (dry condition) for 24 h. It is reported that a commercially available dressing loses about 50% of its bound water after 12 h and retaining about 30% water after 24 h. This water loss enables the coverings to take up exudates and oedema fluid from the wound when used in exudating wounds. [43] Our cryogels have similar properties so that they are expected to use for the wounds with heavy exudates. Figure 9 shows the moisture permeability of the cryogels.…”

Section: Physical and Biological Propertiesmentioning

confidence: 99%

Collagen Cryogel Cross‐Linked by Dialdehyde Starch

Liu

Cheng

et al. 2010

Macro Materials & Eng

118

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A 3D spongy collagen cryogel was prepared using DAS as the cross‐linker. FTIR and CD studies demonstrate that crosslinking is achieved through the reaction of the DAS aldehyde groups with the free amino groups in collagen without affecting the triple helix of collagen. SEM demonstrates that the cryogel has a heteroporous structure with interconnecting pores. DSC measurements reveal that the cryogels have improved thermal stability in comparison with pure collagen. Moreover, the ESR shows that the water uptake of the cryogel decreases with DAS content. Evaporation tests indicate that the cryogel can hold moisture for a long time. Since both collagen and DAS are nontoxic and the resultant cryogel is blood‐compatible, the cryogel is expected to be useful, e.g., as wound dressing.magnified image

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Section: Physical and Biological Propertiesmentioning

confidence: 99%

Collagen Cryogel Cross‐Linked by Dialdehyde Starch

Liu

Cheng

et al. 2010

Macro Materials & Eng

118

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“…Numerous wound dressing materials are commercially available and others have being extensively investigated (Quinn et al, 1985;Kane et al, 1996;Choi et al, 1999;Nambu, 1982 Freeze thawing was firstly reported by Nambu in 1982 and it resulted in the formation of crystallites that serve as physical crosslinks to render the material insoluble in water (Giannouli and Morris, 2003). This method was also used by Giannouli and Morris to form cryo-gels of xanthan (Kichöfen et al, 1986). Several papers have been devoted to evaluate the synthesis and characterisation of PVA cryo-gels by means of freeze thawing the sample with liquid nitrogen (Giannouli and Morris, 2003).…”

Section: Introductionmentioning

confidence: 95%

The rheological and thermal characteristics of freeze-thawed hydrogels containing hydrogen peroxide for potential wound healing applications

Smith

Kennedy

Higginbotham

2009

Journal of the Mechanical Behavior of Biomedical Materials

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“…Hydrogels are one of the most promising types of polymers being used for different biomedical applications and are polymeric materials that do not dissolve in water at a physiological temperature or pH, but swells considerably in an aqueous medium [4,5]. Hydrogels have been widely investigated as wound dressing materials [6][7][8]. These three dimensional materials have the property of moist wound healing with good fluid balance and one can easily monitor healing process due to their transparency [9].…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of pectin/gelatin hydrogel membranes for wound dressing

Mishra

Majeed

Banthia

2011

Int J Plast Technol

119

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The present work deals with the development of pectin-gelatin (PEGE) hydrogel membranes for wound dressing applications. The prepared hydrogels were characterized by FTIR spectroscopy, XRD spectroscopy, water vapor transmission rate (WVTR) test and tensile strength test. Morphology and thermal stability of the membranes were analyzed by Field emission scanning electron microscopy (FESEM) and thermogravimetric analysis (TGA). The swelling studies of the hydrogels were conducted in different pH buffer solutions (pH 1.4, 5.4, 7.4 and 9.4). FTIR spectra of the hydrogels indicated considerable lowering in usual -OH stretching vibration peak of pectin and gelatin, which suggests the development of probable intermolecular interactions between the two natural polymers. XRD study revealed the decrease in crystallinity of hydrogels as compared to parent pectin. The morphological analysis of the hydrogel revealed highly interconnected honeycomb type architecture with pore size ranging from 10 to 40 μm. It was found that increase in gelatin ratio significantly improves the porous nature of the membranes. TGA study showed the enhanced thermal stability of PEGE hydrogel as compared to reference pectin. Tensile strength (TS) and elongation at break (EB) was found to increase with gelatin content in the hydrogel membranes but further increase leads to decrease in TS and EB. The WVTR analysis of the membranes showed the moisture Int J Plast Technol (June 2011) 15(1):82-95 retentive properties indicating its possible use in moist wound care. The PEGE hydrogels were found to be cytocompatible with B16 melanoma cells.

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Chemical and physical properties of a hydrogel wound dressing

Cited by 67 publications

References 5 publications

Collagen Cryogel Cross‐Linked by Dialdehyde Starch

Collagen Cryogel Cross‐Linked by Dialdehyde Starch

The rheological and thermal characteristics of freeze-thawed hydrogels containing hydrogen peroxide for potential wound healing applications

Development and characterization of pectin/gelatin hydrogel membranes for wound dressing

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