Chemical and physical properties of gall stones in South Australia: implications for dissolution treatment.

Whiting, Malcolm J.; Bradley, Ben; Watts, J. F.

doi:10.1136/gut.24.1.11

Cited by 17 publications

(2 citation statements)

References 11 publications

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“…10 The data from the present study support these findings. Cholesterol stones are the most common type of gallstones, and they have been identified as 67.5% of gallstones by Mazlum et al 11 , 70% by Van Erpecum, 3 and 75% by Whiting et al 5 Similarly, we found that 58.7% of the sample gallstones were cholesterol stones. Otherwise, the mean gallstone cholesterol concentration was reported to be 25% by Angwafo et al 12 59.7% by Chandran et al 9 and 60.8% by Jaraari et al 13 We determined that the mean stone cholesterol concentration was 52.1%.…”

Section: Discussionsupporting

confidence: 71%

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The effects of serum cholesterol, LDL, and HDL levels on gallstone cholesterol concentration

et al. 2012

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Objective: Gallbladder stones are common in the Western world, and 70% to 80% of gallstones are cholesterol stones. This study investigates the effects of serum cholesterol, LDL, and HDL levels on gallstone cholesterol concentration. Methodology: The gallstones of 75 patients with cholelithiasis were examined using spectrophotometry. Results: High serum cholesterol and LDL levels were associated with high cholesterol stone rates (86.7% vs. 40.0%, P < 0.001; 75.0% vs. 48.9%, P < 0.05, respectively). Similarly, high serum cholesterol and LDL levels were correlated with high gallbladder stone cholesterol concentrations (63.6% vs. 44.4%, P < 0.001; 62.3% vs. 46.0%, P < 0.001, respectively). In contrast, low serum HDL levels do not seem to affect the occurrence of gallbladder cholesterol stones (60.0% vs. 58.3%, respectively, P > 0.05) or gallbladder stone cholesterol concentrations (50.8% vs. 52.4%, respectively, P > 0.05). Conclusion: The relationship between cholesterol, LDL, and HDL levels and cholesterol gallstone formation is multifactorial and complex and is also dependent on other individual properties.

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Section: Discussionsupporting

confidence: 71%

“…2 The stones with cholesterol concentrations higher than 50% are considered to be cholesterol stones, 3 and 70% to 80% of gallstones are cholesterol stones. 4 , 5 …”

Section: Introductionmentioning

confidence: 99%

The effects of serum cholesterol, LDL, and HDL levels on gallstone cholesterol concentration

et al. 2012

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How Many Americans Will Be Eligible for Biliary Lithotripsy?

Magnuson

Lillemoe

Pitt³

1989

Arch Surg

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Chemical composition of common bile duct stones

Whiting

Watts

1986

Journal of British Surgery

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The common bile duct stones obtained from 148 patients were analysed chemically for cholesterol, calcium and bilirubin. When stones were present in both the common bile duct and gallbladder at the time of surgery, the common duct stones were similar in chemical composition to gallbladder stones in the majority of cases and were predominantly cholesterol-type stones. However, common bile duct stones from patients whose gallbladders had been removed at least one year before the detection of common duct stones contained less cholesterol and more bilirubin than common bile duct stones which were associated with gallbladder stones. Thirty per cent of these stones contained suture material in the centre of the stone. Overall, the results indicate that common bile duct stones are more likely to be pigment type than gallbladder stones, especially if the common duct stones are large, have formed in the duct and become symptomatic less than 12 years after cholecystectomy. Non-absorbable suture material should be avoided in surgery involving the common bile duct.

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Chemical and physical properties of gall stones in South Australia: implications for dissolution treatment.

Cited by 17 publications

References 11 publications

The effects of serum cholesterol, LDL, and HDL levels on gallstone cholesterol concentration

The effects of serum cholesterol, LDL, and HDL levels on gallstone cholesterol concentration

How Many Americans Will Be Eligible for Biliary Lithotripsy?

Chemical composition of common bile duct stones

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