Chemical and Pharmacological Significance of 1,4-Dihydropyridines

Abstract

1,4-Dihydropyridines are excellent precursors of various pharmacologically important molecules which possess calcium channel blocking activity. The synthesis of various 1,4-dihydro pyridines and their importance is reviewed for the first time to our knowledge.

New Organocatalytic Asymmetric Synthesis of Highly Substituted Chiral 2-Oxospiro-[indole-3,4′- (1′,4′-dihydropyridine)] Derivatives

“…Moreover, 1,4-dihydropyridine derivatives are a significant class of heterocyclic compounds frequently found in natural products, and many of them also exhibit pharmacological properties [16,17,18,19,20]. As in other drugs, the role of the stereochemistry at C-4 can disclose both qualitative and quantitative differences in the biological activity.…”

1-Benzamido-1,4-dihydropyridine derivatives as anticancer agents: in vitro and in vivo assays

“…1,4-Dihydropyridines are also systems of crucial importance due to their presence in the core of biologically relevant molecules such as cofactors NADH and NADPH (Pollak et al, 2007;Griendling et al, 1994;Liu et al, 2002). Therefore, the involvement of these compounds in many biological processes has turned them into potential therapeutic targets of great interest in medicinal chemistry (Reddy et al, 2007;Mai et al, 2009;Sharma and Singh, 2017;Talwan et al, 2017).…”