Chemical and pharmacological research on the plants from genus <i>Ajuga</i>

Xia, Qiuyuan; Yan, Hui Min; Ni, Zhi Yu; Vavricka, Christopher J.; Zhang, Man Li; Shi, Qing; Gu, Yu‐Cheng; Kiyota, Hiromasa

doi:10.1515/hc-2017-0064

Cited by 29 publications

(15 citation statements)

References 104 publications

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“…Interestingly, we observed no protective effect of the prior exposure of individual sawflies to clerodanoids, neither in the presence, nor absence of the fungus. This is an unexpected result considering that some clerodanoids show antifungal activity (reviewed by Li et al, 2016 ; Qing et al, 2017 ). The lack of a protective effect in this interaction suggests that the in vitro antimicrobial activity reported for some clerodanoids does not necessarily translate into a better protection against a potential pathogen in vivo .…”

Section: Discussionmentioning

confidence: 90%

Survival of the Sawfly Athalia rosae Upon Infection by an Entomopathogenic Fungus and in Relation to Clerodanoid Uptake

Zanchi

Reshma

et al. 2021

Front. Physiol.

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Larvae of the turnip sawfly Athalia rosae are a pest of Brassicacae plants, as their feeding can cause defoliation of various crops of economic importance. The larvae and the adults of this sawfly species are known to take up different classes of chemical compounds from their respective host plants, with potentially deterrent functions against predators. In addition, compounds taken up by the adults, the clerodanoids, are known for their antimicrobial activity. These features could be a challenge to biocontrol strategies. Several natural enemies of A. rosae have been identified, targeting larval and pupal stages of A. rosae, which could potentially be used as biocontrol agents. However, targeting the adult stage of a larval pest in addition to targeting the juvenile stages may improve population control. In this study, we ask whether a strain of the entomopathogenic fungus Beauveria bassiana shows biological activity against A. rosae adults. We also investigate whether the behavior of clerodanoid uptake by the adults, which is commonly found, affects their survival in response to a B. bassiana exposure. We found a clear dose-response relationship, i.e., with increasing fungal conidia concentrations survival of A. rosae decreased. However, there was only a low incidence of mycelial growth and sporulation from A. rosae cadavers, indicating that either the fungus is not successfully developing inside this host, or it is not able to re-emerge from it. Clerodanoid uptake decreased the survival of healthy adults; however, it did not increase their survival to B. bassiana. Our results revealed that this strain of B. bassiana if applied alone is probably not suitable for biocontrol of this sawfly species, because A. rosae showed a high baseline resistance against this fungus. The behavior of clerodanoid uptake is unlikely to have evolved as a defense against this entomopathogenic fungus.

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Section: Discussionmentioning

confidence: 90%

Survival of the Sawfly Athalia rosae Upon Infection by an Entomopathogenic Fungus and in Relation to Clerodanoid Uptake

Zanchi

Reshma

et al. 2021

Front. Physiol.

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“…Much phytochemical research has assessed the separation of Ajuga ingredients. These studies have led to the isolation of several secondary metabolites, including neo-clerodane_diterpenes and diterpenoids, phytoecdysteroid components, flavonoid derivatives, iridoids, sesquiterpenoid compounds, withanolides, phenylethanoid glycoside derivatives, sterols, anthocyanins, and O-coumaric acid compounds (3,8,12,13,15,23,29,34,39,40,(45)(46)(47)(48)(49)(50)(51). Isolated compounds from different Ajuga species growing in Iran are shown in Table 2.…”

Section: Phytochemicalsmentioning

confidence: 99%

Medicinal Importance of Ajuga Species in Iran: Ethnobotanical and Traditional Applications, Phytochemical, and Pharmacological Studies

Rahiminiya

Ghadim

Lamardi

et al. 2022

Jundishapur J Nat Pharm Prod

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Context: Five species of the genus Ajuga (Lamiaceae) having the common name of "bugle" are found in Iran. In Persian medicine (PM), the genus Ajuga (Kamaphytus) is used for treating jaundice, joint pain, gout, amenorrhea, sciatica, and wound healing. This study aimed to review the ethnobotanical, phytochemical, and biological activities of Ajuga species that grow in Iran to determine their therapeutic potentials and suggest further studies on the healing properties of this genus in Iran. Evidence Acquisition: Electronic databases such as PubMed, Scopus, and Google Scholar were comprehensively searched for studies on Ajuga species in Iran, including "Ajuga austro-iranica," "Ajuga chamaecistus," "Ajuga comata" (Syn.: "Ajuga Chia," "Ajuga chamaepitys subsp. Chia"), "Ajuga orientalis," and "Ajuga reptans." The search period was from 1966 to February 2021. The related articles were selected according to the inclusion and exclusion criteria of the current study. Results: Several ethnobotanical and pharmacologic reports have verified the traditional uses of the genus Ajuga for anti-inflammatory, hypoglycemic, hypolipidemic, analgesic, anabolic, anti-arthritis, antipyretic, and hepatoprotective activities. Numerous phytochemicals have been identified from Ajuga species involving phytoecdysteroids, neo-clerodane-diterpenes, iridoids, flavonoids, withanolides, phenylethyl glycoside, and essential oils. Conclusions: Due to the beneficial therapeutic effects of Ajuga genus, it can be considered in future clinical studies as a source of natural antioxidants, dietary supplements in the pharmaceutical industry, and stabilizing food against oxidative deterioration.

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“…A. decumbens is highly rich in diterpenoids as other Ajuga species, diterpenoids from A. decumbens are of two groups that are neoclerodane and abietane [11,[17][18]. Eight diterpenoids were isolated from ethanol extract of A. decumbens, including Ajugacumbins A (1), Ajugacumbins B (2), Ajugacumbins C (3), Ajugacumbins D (4), Ajugamarins A2 (5), Ajugamarins G1(6), Ajugamarins H1(7) and Ajugamarins F4 (8) [19][20].…”

Section: Diterpenoidsmentioning

confidence: 99%

“…The genus Ajuga, belongs to the family of Labiatae, commonly known as "Bugleweed or Ground pine" [1] which distributed mainly in the temperate regions Europe, Asia and Africa [2] where most its species can be found, but only two of Ajuga species are available in southeastern Australia [3][4]. Pharmacological studies revealed that Ajuga possessed, have been used as anti-inflammatory agents, anticancer, astringent, anthelmintic, hypoglycemic, febrifuge diuretic, insecticidal properties and antifungal [5][6][7][8][9][10][11]. Ajuga decumbens is used as a folk medicine for the treatment of all kinds of ailment in ancient, most especially in China and Japan [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Advance of the Chemical Components and Biological Activities of Ajuga Decumbens Thunb

Olatunde

Yang

Yong

et al. 2019

BJSTR

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is an annual herbaceous flowering plant, which grow to 10-30 cm height with white villous on the young parts of the stem, numerous basal leaves longer than stem leaves, floral leaves are bractlike and lanceolate, with funnel-shape calyx and corolla tubular, straight, basally slightly swollen. Flowering starts from March and lasts to the end of July. The fruiting season starts from May and continues till November [16]. Bioactive Compounds Isolated from A. decumbensThere are bioactive compounds isolated from A. decumbens, including diterpenoids, iridoid glycosides, triterpenoids, sesquiterpenoids, phytoecdysteroids, withanolides and other essential compounds, which are responsible for its effective biological activities. Diterpenoids:A. decumbens is highly rich in diterpenoids as other Ajuga species, diterpenoids from A. decumbens are of two groups that are neoclerodane and abietane [11,[17][18]. Eight diterpenoids were isolated from ethanol extract of A. decumbens, including Ajugacumbins A (1), Ajugacumbins B (2), Ajugacumbins C (3), Ajugacumbins D (4), Ajugamarins A2 (5), Ajugamarins G1(6), Ajugamarins H1(7) and Ajugamarins F4 (8) [19][20]. Min et al. also isolated Ajugacumbins E (9) and Ajugacumbins F (10) for the first time [21]. Ajugacumbins G (11) was isolated from A. decumbens [22]. Amano et al. isolated Ajugatakasins A (12), Ajugatakasins B (13), Ajugaside A (14), Ajugapitin (Clerodendrin D) (15) and Dihydroajugamarin (16) from the extract of A. decumbens [23].

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Chemical and pharmacological research on the plants from genus Ajuga

Abstract: The genus

Cited by 29 publications

References 104 publications

Survival of the Sawfly Athalia rosae Upon Infection by an Entomopathogenic Fungus and in Relation to Clerodanoid Uptake

Survival of the Sawfly Athalia rosae Upon Infection by an Entomopathogenic Fungus and in Relation to Clerodanoid Uptake

Medicinal Importance of Ajuga Species in Iran: Ethnobotanical and Traditional Applications, Phytochemical, and Pharmacological Studies

Advance of the Chemical Components and Biological Activities of Ajuga Decumbens Thunb

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