Chemical and Pharmacological Progress on Polyacetylenes Isolated from the Family Apiaceae

Chen, Yuemei; Peng, Shiyi; Luo, Qiongzhi; Zhang, Juan; Guo, Qiang; Zhang, Yuan; Chai, Xingyun

doi:10.1002/cbdv.201300396

Cited by 26 publications

(16 citation statements)

References 95 publications

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“…Polyacetylenes reported in Apiaceae family displayed notable effects on human physiology, and in curing diseases. Carrots, celery, and parsley are examples food plants contain polyacetylenes closely related with human life (Chen et al., 2015). Peak 9 , Rt 8.98 min exhibited [M + H] + at m/z 261.18 [C 17 H 25 O 2 ] + and yielding fragment ions at m/z 219.17, 205.12 and 163.11 assigned as falcarindiol (or Heptadecadiendiynediol), Supporting Figure S3a.…”

Section: Resultsmentioning

confidence: 99%

Anti‐inflammatory and antioxidant effects of Apium graveolens L. extracts mitigate against fatal acetaminophen‐induced acute liver toxicity

et al. 2020

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In the present work, antioxidant activity, total phenolics (TP), and total flavonoids (TF) contents of aqueous and methanol extracts of celery were determined, in addition to untargeted metabolites profiling its methanol celery root extract (MCRE) via UPLC-MS. Although MCRE exhibited the lowest TPC and TFC levels, it presented the most potential hydroxyl radical quenching effect using electron paramagnetic resonance spin trapping technique. Treatment of Acetaminophen-induced hepatotoxicity (AAH) rats with MCRE lowered serum levels of AST, ALT, ALP, TNF-α, and IL-1β significantly. Additionally, MCRE significantly increased total antioxidant capacity (TAC) and glutathione (GSH) levels relative to AAH rats. Strikingly, Kaplan-Meier survival analysis of all groups revealed a 100% prevention of acetaminophen-induced mortality of rats by MCRE pretreatment (100 mg/kg/day). MCRE prevented AAHassociated severe weight loss and elicited normal behavior in the rescued rats. Our results suggest that pretreatment with MCRE can mitigate against overdosed acetaminophen-induced acute liver failure and warrant further investigations on the potential of postinjury intervention.

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Section: Resultsmentioning

confidence: 99%

Anti‐inflammatory and antioxidant effects of Apium graveolens L. extracts mitigate against fatal acetaminophen‐induced acute liver toxicity

et al. 2020

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“…At last, the screened antioxidants were regarded to be the identified polyynes, phenylpropanoids and their derivatives, which were ferulic acid, caffeic acid, homovanillyl alcohol 4‐ O ‐β‐ d ‐glucopyranoside, 3,4‐dihydroxyphenethyl alcohol 4‐ O ‐β‐ d ‐glucopyranoside, 3,5‐dimethoxycinnamyl alcohol 4‐ O ‐β‐ d ‐glucopyranoside, scopoletin, esculetin, and (+)‐isolariciresinol‐9′‐ O ‐β‐ d ‐glucopyranoside (Table ). Polyynes, also known as polyacetylenes, have been discovered in many dietary and herbal plants, which were reported to have antioxidant effects . As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Screening and identifying antioxidants from Oplopanax elatus using 2,2ʹ‐diphenyl‐1‐picrylhydrazyl with off‐line two‐dimensional HPLC coupled with diode array detection and tandem time‐of‐flight mass spectrometry

Shao

Nie

Chen

et al. 2016

J of Separation Science

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The root of Oplopanax elatus (Nakai) Nakai has a well-known history of use for the treatment of diseases such as neurasthenia, cardiovascular disorders, and cancer by the native people in northeast China. It is important to screen and identify the bioactive molecules from its root rapidly. Hereby, an off-line two-dimensional high performance liquid chromatography coupled with diode array detection and tandem time-of-flight mass spectrometry together with 2,2'-diphenyl-1-picrylhydrazyl was established to screen antioxidants from the root of O. elatus. A Waters cyanogen column (150 × 3.9 mm, id, 4 μm) was used for the first dimensional liquid chromatography, while a Hypersil BDS-C18 column (250 × 4.6 mm, id, 5 μm) was installed for the second dimension liquid chromatographic analysis. Twenty-eight compounds had been tentatively identified from the methanol extract of the air-dried root of O. elatus including six polyynes and eight phenolic derivatives were screened with antioxidant activity. The developed method could be expedient for screening and identifying antioxidants from O. elatus.

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“…They also display antidiabetic [47] effects and have potential in the treatment of endotoxemia and inflammation accompanied by the overproduction of NO [48]. Apart from this, they possess neurotoxic, anti-platelet-aggregatory activity and are responsible for allergic skin reactions [49,50,51]. However, polyacetylenes have a major impact on the bitter taste in roots of parsnip, celeriac, parsley and carrot, as well as fennel bulbs [52,53,54,55,56,57,58,59].…”

Section: Polyacetylenesmentioning

confidence: 99%

Nutraceutical Potential of Apiaceae

Aćimović

2017

Reference Series in Phytochemistry

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Apiaceae family is large, with over 3.000 species worldwide cultivated for many purposes. Some plants in this family such as carrots, parsley, parsnip and celery are common vegetable crops, while other members like anise, caraway, coriander, cumin, fennel, lovage, angelica and dill are famous for their medicinal and aromatic properties. Usage of these plants is very popular in everyday diet because of their documented health benefits. Apiaceae are a very important source of phytochemicalschemicals with biological activity. However, phytochemicals are non-nutritive plant chemicals, also called nutraceuticals. They are widely used for prevention, treatment or cure of conditions or diseases. Bioactive compounds with nutraceutical potential are polyphenolic compounds, polyacetylenes and terpenoids. The aim of this review is to represent selected plants of Apiaceae family currently used as nutraceuticals and describe their nutritional benefits.

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Chemical and Pharmacological Progress on Polyacetylenes Isolated from the Family Apiaceae

Cited by 26 publications

References 95 publications

Anti‐inflammatory and antioxidant effects of Apium graveolens L. extracts mitigate against fatal acetaminophen‐induced acute liver toxicity

Anti‐inflammatory and antioxidant effects of Apium graveolens L. extracts mitigate against fatal acetaminophen‐induced acute liver toxicity

Screening and identifying antioxidants from Oplopanax elatus using 2,2ʹ‐diphenyl‐1‐picrylhydrazyl with off‐line two‐dimensional HPLC coupled with diode array detection and tandem time‐of‐flight mass spectrometry

Nutraceutical Potential of Apiaceae

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