Chemical and pharmacological investigations of Epimedium species: A survey

Wu, Hao; Lien, Eric J.; Lien, Linda L.

doi:10.1007/978-3-0348-8012-1_1

Cited by 122 publications

(114 citation statements)

References 39 publications

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“…1A) is a hydrolytic form of icariin which is one of the traditional Chinese herbals (7). Icaritin has been shown to have a wide range of pharmacological and biological activities, including stimulating neuronal differentiation via estrogen-dependent pathway (8,9), promoting differentiation of embryonic stem cells into cardiomyocytes (10,11), inhibiting osteoclast differentiation (12) and promoting apoptosis and suppressing proliferation of prostatic smooth muscle cells (13).…”

Section: Introductionmentioning

confidence: 99%

Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy

Pan

Huang

et al. 2015

Oncology Reports

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Abstract. Bladder cancer is one of the most commonly diagnosed urological malignancies. Acquired resistance to chemotherapy is a great barrier for achieving successful treatment of bladder cancer. In the present study, we investigated the effect and mechanisms of icaritin, a flavonol glycoside derived from genus Epimedium, against human bladder cancer cells. It was found that despite the low cytotoxicity in normal human HEK293 cells, icaritin significantly inhibited the proliferation and colony formation of BT5637 and T24 bladder cancer cells time-and dose-dependently compared to the DMSO vehicle control. Moreover, cell viability monitored through mitochondrial membrane potential was inhibited markedly after icaritin treatment. Further investigation indicated that icaritin may inhibit epirubicin (EPI)-induced autophagy, and acted synergistically with EPI to suppress the proliferation of BT5637 and T24 cells. These findings suggest that icaritin may prove to be a novel potent therapeutic agent for the treatment of bladder cancer.

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Section: Introductionmentioning

confidence: 99%

Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy

Pan

Huang

et al. 2015

Oncology Reports

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“…Many studies have shown that it has a wide range of pharmacological and biological activities on endocrine, cardiovascular, genital, bronchial, urinary and immune systems (12)(13)(14)(15). In vitro studies have demonstrated that icariin possesses antitumor activity (16,17).…”

Section: Introductionmentioning

confidence: 99%

Icariin induces apoptosis in mouse MLTC-10 Leydig tumor cells through activation of the mitochondrial pathway and down-regulation of the expression of piwil4

Xie¹

2011

Int J Oncol

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Abstract. The Leydig cell tumor, derived from interstitial cells, is a rare neoplasm. In most cases, Leydig cell tumors are benign, however, if the tumor is malignant, no effective treatments are currently available. In this study, we aimed to evaluate the effects of icariin on the growth of the mouse Leydig tumor cell line MLTC-1 and to examine its underlying mechanism. Icariin caused a dose-dependent decrease in the viability of MLTC-1 cells, which coincided with an increase in cell apoptosis through regulation of the expression of Bcl-2/Bax and cytochrome c, activation of caspase-9 and -3. Moreover, the pro-apoptotic effect of icariin on MLTC-1 cells is related to piwil4, since icariin induced a decrease in piwil4 protein expression and piwil4 silencing significantly enhanced the cytotoxic effects of icariin in MLTC-1 cells. These findings suggest a novel anticancer effect of icariin in Leydig cell tumor through activation of the mitochondrial pathway and down-regulation of the expression of piwil4. IntroductionTesticular neoplasms include germ cell tumors and sex cord-stromal tumors. Germ cell tumors comprise 95% of all testicular neoplasms, while the remaining 5% of testicular tumors are sex cord-stromal tumors, which are derived from somatic cells, Sertoli and Leydig cells. The Leydig cell tumor is classified as an interstitial cell tumor, which are commonly benign; however, in adults, ~10% of cases are malignant (1-4). The etiology of Leydig cell tumor in humans remains unknown. Currently, in most cases, the standard therapy for benign Leydig cell tumors is considered to be orchiectomy. Recently, by retrospectively analyzing the long-term follow-up of a series of patients with Leydig cell tumors electively treated with testis sparing surgery, Glannarin et al (5) demonstrated that testis sparing surgery with frozen section examination has an excellent long-term oncological outcome. Therefore, testis-sparing surgery may be chosen for treating benign Leydig cell tumors to maintain fertility, especially in boys and young men (5-9). If the tumor is malignant, orchiectomy with retroperitoneal lymph node dissection is recommended, since chemotherapy and radiation therapy show limited efficacy in the treatment of malignant Leydig cell tumors. Survival time of patients with this malignancy range from 2 months to 17 years, and the mean survival time is 2 years (10,11). To improve the survival time of patients with malignant Leydig cell tumor, and to decrease the serious consequences, such as testicular dysfunction and infertility that is caused by the current treatment for benign Leydig cell tumors, alternative treatments need to be explored.Icariin (C 33 H 40 O 15 ; molecular weight, 676.67), a flavonoid isolated from Herba Epimedii, is considered to be the main active component responsible for the actions of Herba Epimedii. Many studies have shown that it has a wide range of pharmacological and biological activities on endocrine, cardiovascular, genital, bronchial, urinary and immune systems (12)(13)(14)(15). In ...

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“…Their therapeutic actions are believed to be mediated through multiple signal pathways and cellular targets. Many herbs that are known to possess "kidneytoning" activities or "bone and gonad nourishing" effects demonstrated to be effective in reducing bone loss and promoting fracture healing (Wu et al, 2003). Cajanus cajan (Linn.)…”

Section: Introductionmentioning

confidence: 99%

Effects of water extract ofCajanus cajanleaves on the osteogenic and adipogenic differentiation of mouse primary bone marrow stromal cells and the adipocytic trans-differentiation of mouse primary osteoblasts

Zhang¹,

Liu²,

Sun³

et al. 2009

Pharmaceutical Biology

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Chemical and pharmacological investigations of Epimedium species: A survey

Cited by 122 publications

References 39 publications

Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy

Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy

Icariin induces apoptosis in mouse MLTC-10 Leydig tumor cells through activation of the mitochondrial pathway and down-regulation of the expression of piwil4

Effects of water extract ofCajanus cajanleaves on the osteogenic and adipogenic differentiation of mouse primary bone marrow stromal cells and the adipocytic trans-differentiation of mouse primary osteoblasts

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