Chemical and pharmacognostical characterization of two Malaysian plants both known as Ajisamat

Mohamad, Tengku Azlan Shah Tengku; Naz, Humera; Jalal, Ratni Suriyani; Hussin, Khatijah Haji; Rahman, Mohd Ruzi A; Adam, Aishah; Weber, Jean Frederic

doi:10.1590/s0102-695x2013000500002

Cited by 8 publications

(1 citation statement)

References 13 publications

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“…Moreover, the physicochemical properties of the corms of two endemic species, C. speciosum and C. robustum were compared with C. autumnale standard corm. Notably, the physicochemical properties of other medicinal plants such as Colchicum luteum, Piper callosum, Salacia macrophylla, and Heracleum persicum are evaluated by some previously performed studies (32)(33)(34)(35).…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Profiles, Physicochemical Analysis, and Biological Activity of Three Colchicum Species

Davoodi

Azadbakht

Hosseinimehr

et al. 2021

Jundishapur J Nat Pharm Prod

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Background: Colchicum is a genus of the Colchicaceae family with various isolated compounds, especially tropolone alkaloids and flavonoids, which are used for osteoarthritis, gout, cancer, inflammatory diseases, jaundice, and sexual impotence in different societies. Objectives: The current study aimed to evaluate the phytochemical and physicochemical properties and anti-inflammatory activities of three Colchicum species. Methods: Total tropolone alkaloid, total phenolic/total tannin, and total flavonoid contents were determined using acidic potassium dichromate, Folin-Ciocalteu, and aluminum chloride methods, respectively. Moreover, the HPLC method was used for identification and quantitation purposes of tropolone alkaloids. Physicochemical properties of three Colchicum species, including macroscopic and organoleptic properties, solubility, foreign matter, ash values, and heavy metal contents, were evaluated. Besides, in vitro anti-inflammatory activities of the corms also were determined using the protein denaturation technique as a rapid screening method. Results: The highest levels of tropolone alkaloid, phenolic compounds, tannins, and flavonoids were observed in C. autumnale, C. speciosum, and C. robustum, respectively. HPLC analysis indicated the presence of colchicine, demecolcine, 2-demethyl colchicine, 3-demethyl colchicine, colchicoside, colchifoline, cornigerine, and N-deacetyl-N-formyl colchicine in these Colchicum species. The physicochemical properties of C. speciosum and C. robustum corms are appropriate compared to the standard Colchicum autumnale corm. Moreover, all Colchicum species exhibited high anti-inflammatory activities compared to standard drugs. Conclusions: This study demonstrated that the corm of the Colchicum species contained similar main compounds with different amounts, as well as appropriate physicochemical properties. Moreover, the valuable biological effects of these plants stimulate the cultivations on a large scale.

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Section: Discussionmentioning

confidence: 99%