Abstract. We study the presence of thermodynamic instabilities in a hot and dense nuclear medium where a nuclear phase transition can take place. Similarly to the low density nuclear liquid-gas phase transition, we show that such a phase transition is characterized by pure hadronic matter with both mechanical instability (fluctuations on the baryon density) that by chemical-diffusive instability (fluctuations on the strangeness concentration). The analysis is performed by requiring the global conservation of baryon number and zero net strangeness in the framework of an effective relativistic mean field theory with the inclusion of the Δ(1232)-isobars, hyperons and the lightest pseudoscalar and vector meson degrees of freedom. It turns out that in this situation hadronic phases with different values of strangeness content may coexist, altering significantly meson-antimeson ratios.We investigate the nuclear medium in the context of relativistic mean field approach, where the nuclear force is mediated by the exchange of isoscalar-scalar (σ), isoscalar-vector (ω) and isovectorvector (ρ) mesons fields in the so-called TM1 parameter set [1,2]. Hyperon degrees of freedom are included taking into account of the determination of the corresponding meson-hyperon coupling constants that have been fitted to hypernuclear properties [3,4].In regime of finite values of temperature and density, a state of high density resonance matter may be formed and the Δ(1232)-isobar degrees of freedom are expected to play a central role [5][6][7][8]. In particular, the formation of resonances matter contributes essentially to baryon stopping, hadronic flow effects and enhanced strangeness. Following Ref.s [2,7], we take into account of the Δ-isobar degree of freedoms.We are dealing with the study of a multi-component system at finite temperature and density with two conserved charges: baryon (B) number and zero net strangeness (S) number (r S = ρ S /ρ B = 0). For what concern the electric charge (Q), we work in symmetric nuclear matter with a fixed value of Z/A = 0.5 and we do not consider fluctuations in the electric charge fraction, due to the high temperature regime considered in the present investigation. Therefore, the electric charge results to be separately conserved in each phase during the phase transition and the chemical potential of particle of index i can be written as μ i = b i μ B + s i μ S , where b i and s i are, respectively, the baryon and the strangeness quantum numbers of i-th hadronic species.By increasing the temperature and the baryon density during the high energy heavy ion collisions, a multi-particle system may take place and the formation of antiparticles become much more relevant. In analogy with the liquid-gas case [9], we are going to investigate the existence of a possible phase transition in the nuclear medium by studying the presence of instabilities (mechanical and/or chemical) in the nuclear equation of state.