Chemical and green synthesis of nanoparticles and their efficacy on cancer cells

Deepak, Paramasivam; Amutha, Vadivel; Kamaraj, Chinnaperumal; Balasubramani, Govindasamy; Aiswarya, Dilipkumar; Perumal, Pachiappan

doi:10.1016/b978-0-08-102579-6.00016-2

Cited by 31 publications

(25 citation statements)

References 70 publications

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“…Studies have also found that nanoparticles affect the functions of the heart and the vasculature, which needs to be carefully assessed. 10 Hence, a new and inventive approach for the green, environmentally-friendly, synthesis of NPs has been introduced and termed "biosynthesis". 11 Biosynthesis focuses on the reduction and elimination of the use or generation of hazardous toxic substances in chemical compounds, especially those used in industrial applications.…”

Section: Introductionmentioning

confidence: 99%

“…13 Nanoparticles synthesized using this method produce many important pharmaceutical molecules that can be effectively applied for targeted drug delivery because toxic chemicals are eliminated. 10,14 Moreover, as will be discussed, many studies have not only highlighted less toxic nanoparticles using such biosynthesis approaches, but their properties for preventing, diagnosis, and treating diseases are also improved.…”

Section: Introductionmentioning

confidence: 99%

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<p>Recent Developments in the Facile Bio-Synthesis of Gold Nanoparticles (AuNPs) and Their Biomedical Applications</p>

Lee

Shameli

Yew

et al. 2020

IJN

306

142

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Gold nanoparticles (AuNPs) are extensively studied nanoparticles (NPs) and are known to have profound applications in medicine. There are various methods to synthesize AuNPs which are generally categorized into two main types: chemical and physical synthesis. Continuous efforts have been devoted to search for other more environmental-friendly and economical large-scale methods, such as environmentally friendly biological methods known as green synthesis. Green synthesis is especially important to minimize the harmful chemical and toxic by-products during the conventional synthesis of AuNPs. Green materials such as plants, fungi, microorganisms, enzymes and biopolymers are currently used to synthesize various NPs. Biosynthesized AuNPs are generally safer for use in biomedical applications since they come from natural materials themselves. Multiple surface functionalities of AuNPs allow them to be more robust and flexible when combined with different biological assemblies or modifications for enhanced applications. This review focuses on recent developments of green synthesized AuNPs and discusses their numerous biomedical applications. Sources of green materials with successful examples and other key parameters that determine the functionalities of AuNPs are also discussed in this review.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Recent Developments in the Facile Bio-Synthesis of Gold Nanoparticles (AuNPs) and Their Biomedical Applications</p>

Lee

Shameli

Yew

et al. 2020

IJN

306

142

View full text Add to dashboard Cite

show abstract

“…Restoring the levels of the downregulated miRNAs in both RCC and PCa could benefit the current cancer therapies and one possible way to do so is through a nanomedicine approach. Nanoparticles (NPs) are small organized structures with sizes between in size 1 and 100 nm that show very specific chemical and physical properties due to their size and composition [86]. Even though the existing research is scarce, NPs can improve the specificity of miRNAs delivery to target cells (thus reducing side effects) and allow for controlled miRNA release [87].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Oxidoreductases-Related MicroRNAs in Glucose Metabolism of Renal Cell Carcinoma and Prostate Cancer

Morais¹,

Dias²,

Prior³

et al. 2021

Oxidoreductase

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The reprogramming of metabolism is one of cancer hallmarks. Glucose’s metabolism, as one of the main fuels of cancer cells, has been the focus of several research studies in the oncology field. However, because cancer is a heterogeneous disease, the disruptions in glucose metabolism are highly variable depending of the cancer. In fact, Renal Cell Carcinoma (RCC) and Prostate Cancer (PCa), the most lethal and common urological neoplasia, respectively, show different disruptions in the main pathways of glucose catabolism: glycolysis, lactate fermentation and Krebs Cycle. Oxidoreductases are a class of enzymes that catalyze electrons transfer from one molecule to another and are present in these three pathways, posing as an opportunity to better understand these catabolic deregulations. Furthermore, nowadays it is recognized that their expression is modulated by microRNAs (miRNAs), in this book chapter, we selected the known miRNAs that directly target these oxidoreductases and analyzed their deregulation in both cancers. The characterization of these miRNAs opens a new door that could be applied in patients’ stratification and therapy monitorization because of their potential as cancer biomarkers. Additionally, their delivery to cancer cells, using glucose capped NPs could help establish new therapeutic strategies that would improve RCC and PCa management.

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“…Besides, it can be readily conducted at room temperature and pressure, thus eliminating the use of high temperature and pressure, in which these issues contribute to huge environmental concerns. Also, not only scale up for large production can be easily done, the synthesized nanoparticles can provide well-defined size and morphology than via other methods of production [23].…”

Section: Green Synthesis Of Copper Nanoparticlesmentioning

confidence: 99%

https://www.ikm.org.my/ojs/index.php/MJChem/article/view/1007

2021

MJCHEM

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Copper nanoparticles have received an immense interest from the scientific community due to their remarkable properties, thus offering various uses in a multitude of applications. Many works have been reported on nanoparticle production using numerous approaches. Despite various methods that can be used for copper nanoparticle preparation, green synthesis outweighs other techniques, as it is a simple, environmentally friendly yet adaptable approach. While some techniques suffer from hazardous environments, complicated procedures and equipment, and time-consuming, the usage of plant extracts is an alternative avenue to produce copper nanoparticles by adopting the green synthesis approach. The synthesis mechanisms and insights into various plant extracts are briefly discussed. Although there is a myriad range of copper nanoparticle applications, this review focuses on the potential of copper nanoparticles in agricultural and environmental applications.

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Chemical and green synthesis of nanoparticles and their efficacy on cancer cells

Cited by 31 publications

References 70 publications

<p>Recent Developments in the Facile Bio-Synthesis of Gold Nanoparticles (AuNPs) and Their Biomedical Applications</p>

<p>Recent Developments in the Facile Bio-Synthesis of Gold Nanoparticles (AuNPs) and Their Biomedical Applications</p>

The Impact of Oxidoreductases-Related MicroRNAs in Glucose Metabolism of Renal Cell Carcinoma and Prostate Cancer

https://www.ikm.org.my/ojs/index.php/MJChem/article/view/1007

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